Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,013
Total Reports
131
Deaths Reported
430.0%
Death Rate
6.7 yr
Avg Age at Report
Average weight at time of report: 7.9 kg (17.4 lbs)
Top Reported Reactions
Vomiting 614
Lethargy (see also Central nervous system depression in 'Neurological') 290
INEFFECTIVE, HEARTWORM LARVAE 270
Emesis 263
Lack of efficacy (ectoparasite) - flea 249
Lack of efficacy - NOS 215
Lack of efficacy (endoparasite) - heartworm 208
Diarrhoea 155
Seizure NOS 131
Lack of efficacy (endoparasite) - hookworm 127
Anorexia 103
Cardiac disorder NOS 91
Ataxia 82
Pruritus 79
Shaking 76
Most Referenced Drugs
Milbemycin Oxime + Spinosad 686
Ivermectin + Pyrantel As Pamoate Salt 353
Spinosad 289
Moxidectin 206
Afoxolaner 194
Trilostane 115
Pyrantel Pamoate;Sarolaner 114
Oclacitinib Maleate 112
Milbemycin Oxime + Praziquantel 96
Imidacloprid + Moxidectin 63
Ivermectin, Pyrantel 59
Sarolaner 59
Carprofen 56
Melarsomine Dihydrochloride 51
Maropitant Citrate 49
Outcome Breakdown
Outcome Unknown
1,007 (36.4%)
Recovered/Normal
845 (30.6%)
Ongoing
585 (21.2%)
Recovered with Sequela
195 (7.1%)
Euthanized
66 (2.4%)
Died
65 (2.4%)
Gender Distribution
Female 1,619 (53.7%)
Male 1,337 (44.4%)
Unknown 49 (1.6%)
Mixed 8 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 136 | |
| 2011 | 184 | |
| 2012 | 228 | |
| 2013 | 279 | |
| 2014 | 239 | |
| 2015 | 229 | |
| 2016 | 226 | |
| 2017 | 261 | |
| 2018 | 201 | |
| 2019 | 218 | |
| 2020 | 174 | |
| 2021 | 121 | |
| 2022 | 118 | |
| 2023 | 151 | |
| 2024 | 148 | |
| 2025 | 100 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #61 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.