Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
161
Total Reports
7
Deaths Reported
430.0%
Death Rate
5.9 yr
Avg Age at Report
Average weight at time of report: 25.8 kg (56.9 lbs)
Top Reported Reactions
Vomiting 23
Emesis 16
Lethargy (see also Central nervous system depression in 'Neurological') 16
Lack of efficacy - NOS 15
Diarrhoea 13
Lack of efficacy (endoparasite) - heartworm 10
INEFFECTIVE, HEARTWORM LARVAE 8
Behavioural disorder NOS 8
Other abnormal test result NOS 8
Lack of efficacy (ectoparasite) - flea 7
Seizure NOS 7
Lack of efficacy (endoparasite) - hookworm 7
Panting 7
Lack of efficacy (ectoparasite) - tick NOS 6
Death by euthanasia 5
Most Referenced Drugs
Milbemycin Oxime + Spinosad 23
Milbemycin Oxime + Praziquantel 21
Moxidectin 13
Lotilaner 13
Spinosad 10
Milbemycin Oxime 9
Lufenuron + Milbemycin Oxime 8
Fluralaner 13.64% 12-Week Chew 8
Imidacloprid + Moxidectin 7
Febantel + Praziquantel + Pyrantel Pamoate 5
Milbemycin Oxime, Lufenuron 5
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 5
Pyrantel Pamoate;Sarolaner 5
Carprofen 4
Nitenpyram 4
Outcome Breakdown
Outcome Unknown
55 (34.2%)
Recovered/Normal
52 (32.3%)
Ongoing
44 (27.3%)
Euthanized
5 (3.1%)
Recovered with Sequela
3 (1.9%)
Died
2 (1.2%)
Gender Distribution
Female 86 (53.4%)
Male 70 (43.5%)
Unknown 4 (2.5%)
Mixed 1 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 4 | |
| 2012 | 16 | |
| 2013 | 16 | |
| 2014 | 21 | |
| 2015 | 7 | |
| 2016 | 6 | |
| 2017 | 8 | |
| 2018 | 4 | |
| 2019 | 10 | |
| 2020 | 7 | |
| 2021 | 6 | |
| 2022 | 10 | |
| 2023 | 15 | |
| 2024 | 23 | |
| 2025 | 7 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #196 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.