Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
287
Total Reports
20
Deaths Reported
700.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 36.6 kg (80.7 lbs)
Top Reported Reactions
Vomiting 61
Diarrhoea 30
Lethargy (see also Central nervous system depression in 'Neurological') 29
Emesis 27
Lack of efficacy (endoparasite) - hookworm 20
Anorexia 17
Digestive tract disorder NOS 17
Lack of efficacy - NOS 11
Death by euthanasia 10
Lack of efficacy (ectoparasite) - flea 9
Pruritus 8
Death 8
Itching 8
Panting 8
Behavioural disorder NOS 7
Most Referenced Drugs
Milbemycin Oxime + Spinosad 37
Ivermectin + Pyrantel As Pamoate Salt 25
Afoxolaner 23
Fluralaner Chew Tablets 23
Spinosad 17
Carprofen 17
Pyrantel Pamoate;Sarolaner 17
Milbemycin Oxime + Praziquantel 13
Oclacitinib Maleate 10
Fluralaner 13.64% 12-Week Chew 10
Moxidectin 9
Afoxolaner 136 Mg Chewable Tablets 9
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 8
Grapiprant 8
Selamectin 7
Outcome Breakdown
Recovered/Normal
101 (38.7%)
Outcome Unknown
80 (30.7%)
Ongoing
56 (21.5%)
Died
12 (4.6%)
Euthanized
8 (3.1%)
Recovered with Sequela
4 (1.5%)
Gender Distribution
Male 142 (49.5%)
Female 137 (47.7%)
Unknown 6 (2.1%)
Mixed 2 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 13 | |
| 2011 | 18 | |
| 2012 | 20 | |
| 2013 | 20 | |
| 2014 | 20 | |
| 2015 | 22 | |
| 2016 | 29 | |
| 2017 | 34 | |
| 2018 | 20 | |
| 2019 | 15 | |
| 2020 | 17 | |
| 2021 | 9 | |
| 2022 | 12 | |
| 2023 | 12 | |
| 2024 | 14 | |
| 2025 | 12 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #167 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.