Total Reports
447
FDA CVM filings
Dog /
FDA CVM · 2025 release 447 reports on file
Shepherd Dog - Anatolian - FDA Adverse Event Profile
Adverse-event records for Shepherd Dog - Anatolian (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Shepherd Dog - Anatolian is #146 by FDA report volume; 4.7% of its 447 reports (21) were death-coded.
- #146
- most-reported dog breed
- 4.7%
- death-coded report share
- 116
- Lack of efficacy (endoparasite) - heartworm - top reaction
- 3.8 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
21
of 447 reports
Death Rate
4.7%
death-coded share
Avg Age at Report
3.8 yr
40.5 kg avg weight
Death-Coded Outcome Share
Shepherd Dog - Anatolian death-coded reports 4.7%
Cross-breed median
4.7% of 447 shepherd dog - anatolian reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 40.5 kg (89.3 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 116
Vomiting 53
Lethargy (see also Central nervous system depression in 'Neurological') 32
Diarrhoea 28
INEFFECTIVE, HEARTWORM LARVAE 28
Lack of efficacy - NOS 18
Lack of efficacy (ectoparasite) - tick NOS 17
Lack of efficacy (ectoparasite) - flea 16
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 87
Milbemycin Oxime + Praziquantel 52
Milbemycin Oxime + Spinosad 50
Moxidectin 47
Pyrantel Pamoate;Sarolaner 34
Fluralaner 13.64% 12-Week Chew 25
Afoxolaner 24
Milbemycin Oxime, Lufenuron 16
Outcome Breakdown
Outcome Unknown
175 (39.1%)
Ongoing
142 (31.8%)
Recovered/Normal
83 (18.6%)
Recovered with Sequela
26 (5.8%)
Died
11 (2.5%)
Euthanized
10 (2.2%)
Gender Distribution
Male 232 (51.9%)
Female 210 (47.0%)
Unknown 4 (0.9%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 1 | |
| 2012 | 12 | |
| 2013 | 5 | |
| 2014 | 15 | |
| 2015 | 17 | |
| 2016 | 23 | |
| 2017 | 34 | |
| 2018 | 29 | |
| 2019 | 41 | |
| 2020 | 53 | |
| 2021 | 47 | |
| 2022 | 41 | |
| 2023 | 47 | |
| 2024 | 49 | |
| 2025 | 33 | |
Shepherd Dog - Anatolian Pet Health Insights
Shepherd Dog - Anatolian accounts for 447 FDA adverse event reports, ranking #146 by volume among dog breeds, with 21 reports (4.7%) coded as a death outcome. Mean age at report: 3.8 years, average weight 40.5 kg (89.3 lbs).
Top reported signs: Lack of efficacy (endoparasite) - heartworm (116), Vomiting (53), Lethargy (see also Central nervous system depression in 'Neurological') (32). Most-referenced drug: Ivermectin + Pyrantel As Pamoate Salt (87 reports), followed by Milbemycin Oxime + Praziquantel (52) and Milbemycin Oxime + Spinosad (50).
Outcome coding on 447 status-recorded reports is dominated by Outcome Unknown (39.1%). Annual submissions ranged 2,011-2,025 across 15 years on file.
Dog Breeds With a Similar Report Volume
Basenji
452 reports · 5.5% death rate
Mastiff (unspecified)
441 reports · 11.8% death rate
Coonhound - Treeing Walker
455 reports · 2.9% death rate
Terrier - Tibetan
439 reports · 2.7% death rate
Pointing Dog - German Wire-haired
468 reports · 4.1% death rate
Terrier - Fox Wire
426 reports · 5.2% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Shepherd Dog - Anatolian? ▼
There are 447 adverse event reports involving Shepherd Dog - Anatolian in the FDA database, with 21 reports involving death (4.7% death rate). Shepherd Dog - Anatolian ranks #146 by report volume.
What are the most common adverse reactions reported for Shepherd Dog - Anatolian? ▼
The most commonly reported adverse reactions for Shepherd Dog - Anatolian are Lack of efficacy (endoparasite) - heartworm (116 reports), Vomiting (53 reports), Lethargy (see also Central nervous system depression in 'Neurological') (32 reports), Diarrhoea (28 reports), INEFFECTIVE, HEARTWORM LARVAE (28 reports).
What drugs are most frequently associated with Shepherd Dog - Anatolian adverse events? ▼
The drugs most frequently referenced in Shepherd Dog - Anatolian adverse event reports are Ivermectin + Pyrantel As Pamoate Salt (87 reports), Milbemycin Oxime + Praziquantel (52 reports), Milbemycin Oxime + Spinosad (50 reports), Moxidectin (47 reports), Pyrantel Pamoate;Sarolaner (34 reports).
What is the average age of Shepherd Dog - Anatolian in adverse event reports? ▼
The average age of Shepherd Dog - Anatolian at the time of adverse event reports is 3.8 years, with an average weight of 40.5 kg (89.3 lbs).
Does a high number of adverse event reports mean Shepherd Dog - Anatolian is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Shepherd Dog - Anatolian safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.