Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
447
Total Reports
21
Deaths Reported
470.0%
Death Rate
3.8 yr
Avg Age at Report
Average weight at time of report: 40.5 kg (89.3 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 116
Vomiting 53
Lethargy (see also Central nervous system depression in 'Neurological') 32
Diarrhoea 28
INEFFECTIVE, HEARTWORM LARVAE 28
Lack of efficacy - NOS 18
Lack of efficacy (ectoparasite) - tick NOS 17
Lack of efficacy (ectoparasite) - flea 16
Lack of efficacy (endoparasite) - roundworm NOS 16
Lack of efficacy (endoparasite) - hookworm 15
Lack of efficacy (endoparasite) - tapeworm 15
Underdose 14
Death 12
Lack of efficacy (bacteria) - Borrelia 12
Death by euthanasia 10
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 87
Milbemycin Oxime + Praziquantel 52
Milbemycin Oxime + Spinosad 50
Moxidectin 47
Pyrantel Pamoate;Sarolaner 34
Fluralaner 13.64% 12-Week Chew 25
Afoxolaner 24
Milbemycin Oxime, Lufenuron 16
Melarsomine Dihydrochloride 15
Ivermectin 13
Sarolaner 12
Milbemycin Oxime 11
Fluralaner Chew Tablets 11
Lotilaner 11
Carprofen 9
Outcome Breakdown
Outcome Unknown
175 (39.1%)
Ongoing
142 (31.8%)
Recovered/Normal
83 (18.6%)
Recovered with Sequela
26 (5.8%)
Died
11 (2.5%)
Euthanized
10 (2.2%)
Gender Distribution
Male 232 (51.9%)
Female 210 (47.0%)
Unknown 4 (0.9%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 1 | |
| 2012 | 12 | |
| 2013 | 5 | |
| 2014 | 15 | |
| 2015 | 17 | |
| 2016 | 23 | |
| 2017 | 34 | |
| 2018 | 29 | |
| 2019 | 41 | |
| 2020 | 53 | |
| 2021 | 47 | |
| 2022 | 41 | |
| 2023 | 47 | |
| 2024 | 49 | |
| 2025 | 33 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #146 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.