Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
13,509
Total Reports
411
Deaths Reported
300.0%
Death Rate
5.8 yr
Avg Age at Report
Average weight at time of report: 11.6 kg (25.6 lbs)
Top Reported Reactions
Vomiting 2,628
Emesis 1,484
Lethargy (see also Central nervous system depression in 'Neurological') 1,172
Lack of efficacy (endoparasite) - heartworm 1,120
Lack of efficacy (ectoparasite) - flea 886
Diarrhoea 838
Lack of efficacy - NOS 715
Lack of efficacy (endoparasite) - hookworm 641
Seizure NOS 570
INEFFECTIVE, HEARTWORM LARVAE 564
Not eating 339
Anorexia 336
Behavioural disorder NOS 325
Digestive tract disorder NOS 311
Emesis (multiple) 304
Most Referenced Drugs
Milbemycin Oxime + Spinosad 2,881
Ivermectin + Pyrantel As Pamoate Salt 1,429
Pyrantel Pamoate;Sarolaner 1,048
Spinosad 998
Moxidectin 885
Fluralaner Chew Tablets 711
Afoxolaner 704
Milbemycin Oxime + Praziquantel 532
Fluralaner 13.64% 12-Week Chew 516
Oclacitinib Maleate 500
Trilostane 404
Sarolaner 366
Bedinvetmab 333
Ivermectin 234
Carprofen 232
Outcome Breakdown
Recovered/Normal
4,716 (34.9%)
Outcome Unknown
3,943 (29.2%)
Ongoing
3,865 (28.6%)
Recovered with Sequela
574 (4.2%)
Euthanized
215 (1.6%)
Died
196 (1.5%)
Gender Distribution
Female 6,737 (49.9%)
Male 6,586 (48.8%)
Unknown 173 (1.3%)
Mixed 13 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 20 | |
| 2011 | 348 | |
| 2012 | 997 | |
| 2013 | 802 | |
| 2014 | 831 | |
| 2015 | 954 | |
| 2016 | 964 | |
| 2017 | 1,069 | |
| 2018 | 1,010 | |
| 2019 | 1,011 | |
| 2020 | 948 | |
| 2021 | 888 | |
| 2022 | 774 | |
| 2023 | 937 | |
| 2024 | 1,210 | |
| 2025 | 746 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #15 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.