Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
7,534
Total Reports
300
Deaths Reported
400.0%
Death Rate
6.1 yr
Avg Age at Report
Average weight at time of report: 12.0 kg (26.5 lbs)
Top Reported Reactions
Vomiting 1,656
Emesis 1,253
Lethargy (see also Central nervous system depression in 'Neurological') 627
Diarrhoea 598
Lack of efficacy (ectoparasite) - flea 563
Lack of efficacy - NOS 467
Lack of efficacy (endoparasite) - hookworm 413
Digestive tract disorder NOS 345
Seizure NOS 302
INEFFECTIVE, HEARTWORM LARVAE 250
Anorexia 207
Other abnormal test result NOS 206
INEFFECTIVE, ASCARIDS NOS 174
Pruritus 156
Behavioural disorder NOS 153
Most Referenced Drugs
Milbemycin Oxime + Spinosad 2,050
Spinosad 1,007
Ivermectin + Pyrantel As Pamoate Salt 723
Afoxolaner 518
Milbemycin Oxime + Praziquantel 211
Oclacitinib Maleate 184
Fluralaner Chew Tablets 175
Cyclosporine 150
Fluralaner 13.64% 12-Week Chew 136
Moxidectin 130
Cyclosporine A 128
Pyrantel Pamoate;Sarolaner 127
Carprofen 122
Selamectin 115
Ivermectin, Pyrantel 112
Outcome Breakdown
Recovered/Normal
2,878 (43.4%)
Outcome Unknown
2,187 (33.0%)
Ongoing
994 (15.0%)
Recovered with Sequela
278 (4.2%)
Died
179 (2.7%)
Euthanized
121 (1.8%)
Gender Distribution
Female 3,769 (50.0%)
Male 3,620 (48.0%)
Unknown 128 (1.7%)
Mixed 17 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 482 | |
| 2011 | 722 | |
| 2012 | 816 | |
| 2013 | 772 | |
| 2014 | 715 | |
| 2015 | 736 | |
| 2016 | 632 | |
| 2017 | 579 | |
| 2018 | 408 | |
| 2019 | 353 | |
| 2020 | 342 | |
| 2021 | 265 | |
| 2022 | 215 | |
| 2023 | 180 | |
| 2024 | 185 | |
| 2025 | 132 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #27 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.