Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,623
Total Reports
48
Deaths Reported
300.0%
Death Rate
4.4 yr
Avg Age at Report
Average weight at time of report: 29.2 kg (64.4 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 418
INEFFECTIVE, HEARTWORM LARVAE 257
Vomiting 178
Diarrhoea 91
Lack of efficacy - NOS 90
Cardiac disorder NOS 72
Lethargy (see also Central nervous system depression in 'Neurological') 70
Lack of efficacy (ectoparasite) - flea 66
Lack of efficacy (endoparasite) - hookworm 65
Seizure NOS 52
Emesis 48
Lack of efficacy (ectoparasite) - tick NOS 40
Lack of efficacy (bacteria) - Borrelia 34
Decreased appetite 31
Emesis (multiple) 30
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 300
Milbemycin Oxime + Spinosad 229
Moxidectin 176
Pyrantel Pamoate;Sarolaner 149
Milbemycin Oxime + Praziquantel 96
Afoxolaner 89
Fluralaner 13.64% 12-Week Chew 72
Bedinvetmab 47
Milbemycin Oxime 40
Fluralaner Chew Tablets 38
Carprofen 36
Spinosad 32
Melarsomine Dihydrochloride 32
Ivermectin, Pyrantel 29
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 29
Outcome Breakdown
Ongoing
566 (36.8%)
Outcome Unknown
507 (32.9%)
Recovered/Normal
297 (19.3%)
Recovered with Sequela
122 (7.9%)
Died
24 (1.6%)
Euthanized
24 (1.6%)
Gender Distribution
Male 950 (58.5%)
Female 641 (39.5%)
Unknown 29 (1.8%)
Mixed 3 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 33 | |
| 2011 | 70 | |
| 2012 | 57 | |
| 2013 | 56 | |
| 2014 | 59 | |
| 2015 | 97 | |
| 2016 | 95 | |
| 2017 | 88 | |
| 2018 | 105 | |
| 2019 | 123 | |
| 2020 | 128 | |
| 2021 | 130 | |
| 2022 | 131 | |
| 2023 | 160 | |
| 2024 | 168 | |
| 2025 | 123 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #83 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.