Total Reports
5,264
FDA CVM filings
Dog /
FDA CVM · 2025 release 5,264 reports on file
Mixed (Dog) - FDA Adverse Event Profile
Adverse-event records for Mixed (Dog) (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Mixed (Dog) is #40 by FDA report volume; 5.7% of its 5,264 reports (302) were death-coded.
- #40
- most-reported dog breed
- 5.7%
- death-coded report share
- 1,122
- Vomiting - top reaction
- 5.4 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
302
of 5,264 reports
Death Rate
5.7%
death-coded share
Avg Age at Report
5.4 yr
18.5 kg avg weight
Death-Coded Outcome Share
Mixed (Dog) death-coded reports 5.7%
Cross-breed median
5.7% of 5,264 mixed (dog) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 18.5 kg (40.8 lbs)
Top Reported Reactions
Vomiting 1,122
Lethargy (see also Central nervous system depression in 'Neurological') 564
Diarrhoea 449
Lack of efficacy (ectoparasite) - flea 310
Lack of efficacy - NOS 267
INEFFECTIVE, HEARTWORM LARVAE 258
Anorexia 256
Emesis 227
Lack of efficacy (endoparasite) - heartworm 204
Other abnormal test result NOS 189
Seizure NOS 183
Pruritus 170
Behavioural disorder NOS 161
Lack of efficacy (endoparasite) - hookworm 157
Ataxia 135
Most Referenced Drugs
Moxidectin 384
Afoxolaner 345
Imidacloprid + Moxidectin 338
Carprofen 305
Milbemycin Oxime + Spinosad 302
Selamectin 264
Oclacitinib Maleate 235
Pyrantel Pamoate;Sarolaner 205
Ivermectin + Pyrantel As Pamoate Salt 189
Sarolaner 185
Pyrantel Pamoate/Praziquantel 164
Bedinvetmab 161
Spinosad 147
Ivermectin, Pyrantel 136
Febantel + Praziquantel + Pyrantel Pamoate 115
Outcome Breakdown
Recovered/Normal
1,681 (34.9%)
Outcome Unknown
1,514 (31.4%)
Ongoing
1,249 (25.9%)
Died
168 (3.5%)
Euthanized
138 (2.9%)
Recovered with Sequela
68 (1.4%)
Gender Distribution
Female 2,207 (41.9%)
Male 2,056 (39.1%)
Mixed 725 (13.8%)
Unknown 276 (5.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 314 | |
| 2011 | 434 | |
| 2012 | 642 | |
| 2013 | 569 | |
| 2014 | 291 | |
| 2015 | 327 | |
| 2016 | 561 | |
| 2017 | 441 | |
| 2018 | 150 | |
| 2019 | 263 | |
| 2020 | 189 | |
| 2021 | 195 | |
| 2022 | 226 | |
| 2023 | 205 | |
| 2024 | 325 | |
| 2025 | 132 | |
Mixed (Dog) Pet Health Insights
Mixed (Dog) accounts for 5,264 FDA adverse event reports, ranking #40 by volume among dog breeds, with 302 reports (5.7%) coded as a death outcome. Mean age at report: 5.4 years, average weight 18.5 kg (40.8 lbs).
Top reported signs: Vomiting (1,122), Lethargy (see also Central nervous system depression in 'Neurological') (564), Diarrhoea (449). Most-referenced drug: Moxidectin (384 reports), followed by Afoxolaner (345) and Imidacloprid + Moxidectin (338).
Outcome coding on 4,818 status-recorded reports is dominated by Recovered/Normal (34.9%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Schnauzer (unspecified)
5,279 reports · 4.1% death rate
Poodle - Miniature
5,328 reports · 3.5% death rate
Spaniel - King Charles Cavalier
5,775 reports · 4.3% death rate
Dog (other)
5,792 reports · 4.1% death rate
Hound (unspecified)
4,645 reports · 2.3% death rate
Doberman Pinscher
4,495 reports · 5.7% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Mixed (Dog)? ▼
There are 5,264 adverse event reports involving Mixed (Dog) in the FDA database, with 302 reports involving death (5.7% death rate). Mixed (Dog) ranks #40 by report volume.
What are the most common adverse reactions reported for Mixed (Dog)? ▼
The most commonly reported adverse reactions for Mixed (Dog) are Vomiting (1,122 reports), Lethargy (see also Central nervous system depression in 'Neurological') (564 reports), Diarrhoea (449 reports), Lack of efficacy (ectoparasite) - flea (310 reports), Lack of efficacy - NOS (267 reports).
What drugs are most frequently associated with Mixed (Dog) adverse events? ▼
The drugs most frequently referenced in Mixed (Dog) adverse event reports are Moxidectin (384 reports), Afoxolaner (345 reports), Imidacloprid + Moxidectin (338 reports), Carprofen (305 reports), Milbemycin Oxime + Spinosad (302 reports).
What is the average age of Mixed (Dog) in adverse event reports? ▼
The average age of Mixed (Dog) at the time of adverse event reports is 5.4 years, with an average weight of 18.5 kg (40.8 lbs).
Does a high number of adverse event reports mean Mixed (Dog) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Mixed (Dog) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.