Dog /

Breed profile · FDA CVM July 2026 extract

Mixed (Dog) adverse-event record

Adverse-event filings for Mixed (Dog) (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

Verify with FDA CVM →
#40 of 510
by report volume (all breeds)
5,355
FDA CVM reports on file
5.7%
death-coded share of reports
#109 of 275
by death-coded share (≥50 reports)

How the 5,355 reports break down

By recorded gender -- every report on file for Mixed (Dog), no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 329 246.75 164.5 82.25 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Mixed (Dog) drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Mixed (Dog) ranks #40 of 510 by total reports (5,355) and #109 of 275 by death-coded share (5.7%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#40
This breed, reports of 510
#109
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Mixed (Dog) has 5,355 reports now versus 5,320 in that prior snapshot: 35 more (0.7%).

Report change
+35
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Mixed (Dog) changes

Total Reports

5,355

Highest-reported breed

Deaths Reported

305

of 5,355 reports

Death-coded share of reports

5.7%

Above-median death-coded share

Avg Age at Report

5.4 yr

18.6 kg avg weight

Breed Safety Scorecard

D (48/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
5.7%

Share of reports coded as a fatality

Euthanasia rate F
2.6%

Share of reports resulting in euthanasia

Full recovery rate C+
31.6%

Share of reports coded "Recovered/Normal"

5-year trend C+
-2%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Mixed (Dog) death-coded reports 5.7%
Cross-breed median

5.7% of 5,355 mixed (dog) reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Mixed (Dog)'s death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

6% 60th percentile Higher share than 60% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Mixed (Dog) 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Mixed (Dog) among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Mixed (Dog) vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 18.6 kg (41.0 lbs)

Top Reported Reactions

Vomiting 1,131
Lethargy (see also Central nervous system depression in 'Neurological') 563
Diarrhoea 454
Lack of efficacy (ectoparasite) - flea 326
Lack of efficacy - NOS 272
INEFFECTIVE, HEARTWORM LARVAE 258
Anorexia 257
Emesis 227
Lack of efficacy (endoparasite) - heartworm 215
Other abnormal test result NOS 190
Seizure NOS 186
Pruritus 170
Lack of efficacy (endoparasite) - hookworm 163
Behavioural disorder NOS 162
Ataxia 135

Most Referenced Drugs

Moxidectin 391
Afoxolaner 351
Imidacloprid + Moxidectin 338
Carprofen 306
Milbemycin Oxime + Spinosad 305
Selamectin 264
Oclacitinib Maleate 236
Pyrantel Pamoate;Sarolaner 218
Ivermectin + Pyrantel As Pamoate Salt 192
Sarolaner 186
Pyrantel Pamoate/Praziquantel 164
Bedinvetmab 164
Spinosad 147
Ivermectin, Pyrantel 136
Febantel + Praziquantel + Pyrantel Pamoate 115

Outcome Breakdown

Recovered/Normal
1,694 (34.5%)
Outcome Unknown
1,551 (31.6%)
Ongoing
1,285 (26.2%)
Died
169 (3.4%)
Euthanized
140 (2.9%)
Recovered with Sequela
69 (1.4%)

Gender Distribution

Female 2,248 (42.0%)
Male 2,086 (39.0%)
Mixed 741 (13.8%)
Unknown 280 (5.2%)

Reports by Year

Year Reports Trend
2010 314
2011 434
2012 642
2013 569
2014 291
2015 327
2016 561
2017 441
2018 151
2019 263
2020 189
2021 196
2022 226
2023 205
2024 329
2025 192
2026 25

Mixed (Dog): high-volume FDA adverse-event cohort

Signature read: 5,355 reports place Mixed (Dog) in the upper third of breed filing volume (#40 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Mixed (Dog) sits at #40 of 510 by report volume among all breeds and #35 of 298 among dog breeds, with 5,355 reports and 305 (5.7%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #109 of 275. Mean age at report: 5.4 years, average weight 18.6 kg (41.0 lbs).

Top reported signs: Vomiting (1,131), Lethargy (see also Central nervous system depression in 'Neurological') (563), Diarrhoea (454). Most-referenced drug: Moxidectin (391 reports), followed by Afoxolaner (351) and Imidacloprid + Moxidectin (338).

Outcome coding on 4,908 status-recorded reports is dominated by Recovered/Normal (34.5%). Annual submissions ranged 25-2,026 across 17 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Schnauzer (unspecified)
5,387 reports · 4.1% death-coded
Poodle - Miniature
5,483 reports · 3.6% death-coded
Hound (unspecified)
4,864 reports · 2.3% death-coded
Dog (other)
5,922 reports · 4.3% death-coded
Spaniel - King Charles Cavalier
6,052 reports · 4.2% death-coded
Poodle - Standard
4,638 reports · 3.1% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Mixed (Dog) drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (5.7% death-coded here).

Norwegian Forest 5.7% · Cat Egyptian Mau 5.3% · Cat Crossbred Feline/cat 6.3% · Cat Scottish Fold Longhair 4.8% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (18.6 kg here).

Pygmy 20.3 kg · Goat Crossbred Caprine/goat 21.7 kg · Goat Wild cat 14.5 kg · Cat Mixed (Sheep) 24.9 kg · Sheep

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Mixed (Dog)? ▼
There are 5,355 adverse event reports involving Mixed (Dog) in the FDA database, of which 305 were death-coded (5.7% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Mixed (Dog) ranks #40 of 510 by report volume among all breeds PlainBreed indexes (#35 of 298 among dog breeds).
Where does Mixed (Dog) sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Mixed (Dog) is #40 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #35 of 298. Among breeds with at least 50 reports, its death-coded share ranks #109 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Mixed (Dog)? ▼
The most commonly reported adverse reactions for Mixed (Dog) are Vomiting (1,131 reports), Lethargy (see also Central nervous system depression in 'Neurological') (563 reports), Diarrhoea (454 reports), Lack of efficacy (ectoparasite) - flea (326 reports), Lack of efficacy - NOS (272 reports).
What drugs are most frequently associated with Mixed (Dog) adverse events? ▼
The drugs most frequently referenced in Mixed (Dog) adverse event reports are Moxidectin (391 reports), Afoxolaner (351 reports), Imidacloprid + Moxidectin (338 reports), Carprofen (306 reports), Milbemycin Oxime + Spinosad (305 reports).
What is the average age of Mixed (Dog) in adverse event reports? ▼
The average age of Mixed (Dog) at the time of adverse event reports is 5.4 years, with an average weight of 18.6 kg (41.0 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Mixed (Dog) (Dog), extract as of July 2026 extract. 5,355 reports · 305 death-coded (5.7% of reports, not a mortality rate) · #40 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →