Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
5,264
Total Reports
302
Deaths Reported
570.0%
Death Rate
5.4 yr
Avg Age at Report
Average weight at time of report: 18.5 kg (40.8 lbs)
Top Reported Reactions
Vomiting 1,122
Lethargy (see also Central nervous system depression in 'Neurological') 564
Diarrhoea 449
Lack of efficacy (ectoparasite) - flea 310
Lack of efficacy - NOS 267
INEFFECTIVE, HEARTWORM LARVAE 258
Anorexia 256
Emesis 227
Lack of efficacy (endoparasite) - heartworm 204
Other abnormal test result NOS 189
Seizure NOS 183
Pruritus 170
Behavioural disorder NOS 161
Lack of efficacy (endoparasite) - hookworm 157
Ataxia 135
Most Referenced Drugs
Moxidectin 384
Afoxolaner 345
Imidacloprid + Moxidectin 338
Carprofen 305
Milbemycin Oxime + Spinosad 302
Selamectin 264
Oclacitinib Maleate 235
Pyrantel Pamoate;Sarolaner 205
Ivermectin + Pyrantel As Pamoate Salt 189
Sarolaner 185
Pyrantel Pamoate/Praziquantel 164
Bedinvetmab 161
Spinosad 147
Ivermectin, Pyrantel 136
Febantel + Praziquantel + Pyrantel Pamoate 115
Outcome Breakdown
Recovered/Normal
1,681 (34.9%)
Outcome Unknown
1,514 (31.4%)
Ongoing
1,249 (25.9%)
Died
168 (3.5%)
Euthanized
138 (2.9%)
Recovered with Sequela
68 (1.4%)
Gender Distribution
Female 2,207 (41.9%)
Male 2,056 (39.1%)
Mixed 725 (13.8%)
Unknown 276 (5.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 314 | |
| 2011 | 434 | |
| 2012 | 642 | |
| 2013 | 569 | |
| 2014 | 291 | |
| 2015 | 327 | |
| 2016 | 561 | |
| 2017 | 441 | |
| 2018 | 150 | |
| 2019 | 263 | |
| 2020 | 189 | |
| 2021 | 195 | |
| 2022 | 226 | |
| 2023 | 205 | |
| 2024 | 325 | |
| 2025 | 132 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #40 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.