Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
389
Total Reports
14
Deaths Reported
360.0%
Death Rate
5.3 yr
Avg Age at Report
Average weight at time of report: 29.7 kg (65.5 lbs)
Top Reported Reactions
Vomiting 57
Lethargy (see also Central nervous system depression in 'Neurological') 37
Diarrhoea 34
Lack of efficacy (endoparasite) - hookworm 29
Emesis 28
Digestive tract disorder NOS 24
Lack of efficacy - NOS 23
Lack of efficacy (endoparasite) - heartworm 23
INEFFECTIVE, ASCARIDS NOS 20
INEFFECTIVE, HEARTWORM LARVAE 17
Anorexia 17
INEFFECTIVE, HOOKS 16
Death by euthanasia 14
Elevated serum alkaline phosphatase (SAP) 13
Lethargy (see also Central nervous system depression in Neurological) 13
Most Referenced Drugs
Milbemycin Oxime + Spinosad 55
Ivermectin + Pyrantel As Pamoate Salt 55
Afoxolaner 26
Pyrantel Pamoate;Sarolaner 24
Spinosad 20
Carprofen 20
Milbemycin Oxime + Praziquantel 20
Oclacitinib Maleate 15
Fluralaner Chew Tablets 15
Bedinvetmab 13
Prednisone 12
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 11
Moxidectin 9
Lufenuron + Milbemycin Oxime 8
Gabapentin 8
Outcome Breakdown
Outcome Unknown
127 (35.2%)
Recovered/Normal
112 (31.0%)
Ongoing
95 (26.3%)
Recovered with Sequela
13 (3.6%)
Euthanized
8 (2.2%)
Died
6 (1.7%)
Gender Distribution
Male 229 (58.9%)
Female 154 (39.6%)
Unknown 4 (1.0%)
Mixed 2 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 8 | |
| 2011 | 23 | |
| 2012 | 22 | |
| 2013 | 32 | |
| 2014 | 34 | |
| 2015 | 28 | |
| 2016 | 32 | |
| 2017 | 35 | |
| 2018 | 32 | |
| 2019 | 25 | |
| 2020 | 26 | |
| 2021 | 12 | |
| 2022 | 16 | |
| 2023 | 17 | |
| 2024 | 34 | |
| 2025 | 13 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #152 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.