Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
23,826
Total Reports
842
Deaths Reported
350.0%
Death Rate
6.0 yr
Avg Age at Report
Average weight at time of report: 6.4 kg (14.1 lbs)
Top Reported Reactions
Vomiting 5,923
Emesis 2,887
Lethargy (see also Central nervous system depression in 'Neurological') 2,587
Lack of efficacy (ectoparasite) - flea 2,215
Diarrhoea 1,923
Lack of efficacy - NOS 1,112
Seizure NOS 977
Anorexia 926
Lack of efficacy (endoparasite) - hookworm 814
Emesis (multiple) 681
Behavioural disorder NOS 654
Pruritus 624
Not eating 597
Other abnormal test result NOS 549
Decreased appetite 520
Most Referenced Drugs
Milbemycin Oxime + Spinosad 4,835
Spinosad 2,426
Afoxolaner 1,570
Ivermectin + Pyrantel As Pamoate Salt 1,501
Fluralaner Chew Tablets 1,201
Oclacitinib Maleate 1,166
Pyrantel Pamoate;Sarolaner 1,141
Moxidectin 997
Trilostane 803
Fluralaner 13.64% 12-Week Chew 727
Milbemycin Oxime + Praziquantel 619
Sarolaner 580
Imidacloprid + Moxidectin 457
Selamectin 448
Nitenpyram 418
Outcome Breakdown
Recovered/Normal
9,210 (41.4%)
Outcome Unknown
6,639 (29.9%)
Ongoing
4,886 (22.0%)
Recovered with Sequela
653 (2.9%)
Died
474 (2.1%)
Euthanized
368 (1.7%)
Gender Distribution
Female 11,670 (49.0%)
Male 11,618 (48.8%)
Unknown 473 (2.0%)
Mixed 65 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 820 | |
| 2011 | 1,308 | |
| 2012 | 1,963 | |
| 2013 | 1,992 | |
| 2014 | 1,860 | |
| 2015 | 2,013 | |
| 2016 | 1,964 | |
| 2017 | 1,911 | |
| 2018 | 1,569 | |
| 2019 | 1,463 | |
| 2020 | 1,365 | |
| 2021 | 1,242 | |
| 2022 | 1,118 | |
| 2023 | 1,159 | |
| 2024 | 1,299 | |
| 2025 | 780 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #9 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.