Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
173
Total Reports
12
Deaths Reported
690.0%
Death Rate
8.0 yr
Avg Age at Report
Average weight at time of report: 23.6 kg (52.0 lbs)
Top Reported Reactions
Vomiting 28
Diarrhoea 25
Emesis 16
Lethargy (see also Central nervous system depression in 'Neurological') 15
Other abnormal test result NOS 11
Lack of efficacy (endoparasite) - hookworm 9
Seizure NOS 8
INEFFECTIVE, HEARTWORM LARVAE 7
Death by euthanasia 7
Deafness 7
Lack of efficacy - NOS 7
Digestive tract disorder NOS 6
Inappetence 6
Elevated blood urea nitrogen (BUN) 5
Not eating 5
Most Referenced Drugs
Milbemycin Oxime + Spinosad 41
Milbemycin Oxime + Praziquantel 15
Bedinvetmab 13
Carprofen 11
Moxidectin 9
Pyrantel Pamoate;Sarolaner 6
Prednisone 5
Milbemycin Oxime 5
Ivermectin + Pyrantel As Pamoate Salt 5
Fluralaner Chew Tablets 5
Milbemycin 4
Maropitant Citrate 4
Cefovecin 4
Fluralaner 13.64% 12-Week Chew 4
Milbemycin Oxime, Lufenuron 4
Outcome Breakdown
Recovered/Normal
48 (31.2%)
Outcome Unknown
48 (31.2%)
Ongoing
38 (24.7%)
Recovered with Sequela
8 (5.2%)
Euthanized
7 (4.5%)
Died
5 (3.2%)
Gender Distribution
Female 86 (49.7%)
Male 79 (45.7%)
Unknown 6 (3.5%)
Mixed 2 (1.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 4 | |
| 2011 | 13 | |
| 2012 | 18 | |
| 2013 | 21 | |
| 2014 | 8 | |
| 2015 | 15 | |
| 2016 | 11 | |
| 2017 | 12 | |
| 2018 | 3 | |
| 2019 | 11 | |
| 2020 | 11 | |
| 2021 | 11 | |
| 2022 | 9 | |
| 2023 | 5 | |
| 2024 | 20 | |
| 2025 | 1 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #193 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.