Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
31,142
Total Reports
1,347
Deaths Reported
430.0%
Death Rate
4.5 yr
Avg Age at Report
Average weight at time of report: 33.0 kg (72.8 lbs)
Top Reported Reactions
Vomiting 4,509
Lack of efficacy (endoparasite) - heartworm 4,371
INEFFECTIVE, HEARTWORM LARVAE 3,122
Diarrhoea 2,315
Emesis 1,922
Lethargy (see also Central nervous system depression in 'Neurological') 1,860
Lack of efficacy - NOS 1,834
Lack of efficacy (endoparasite) - hookworm 1,556
Lack of efficacy (ectoparasite) - flea 1,371
Digestive tract disorder NOS 879
Seizure NOS 833
Cardiac disorder NOS 825
Anorexia 823
Lack of efficacy (ectoparasite) - tick NOS 752
Death 670
Most Referenced Drugs
Milbemycin Oxime + Spinosad 5,496
Ivermectin + Pyrantel As Pamoate Salt 4,912
Afoxolaner 2,006
Pyrantel Pamoate;Sarolaner 1,986
Milbemycin Oxime + Praziquantel 1,894
Moxidectin 1,655
Spinosad 1,270
Fluralaner Chew Tablets 1,151
Oclacitinib Maleate 1,105
Bedinvetmab 975
Carprofen 894
Fluralaner 13.64% 12-Week Chew 883
Melarsomine Dihydrochloride 577
Sarolaner 540
Ivermectin, Pyrantel 515
Outcome Breakdown
Outcome Unknown
10,451 (35.6%)
Ongoing
8,275 (28.2%)
Recovered/Normal
7,358 (25.1%)
Recovered with Sequela
1,889 (6.4%)
Died
790 (2.7%)
Euthanized
557 (1.9%)
Gender Distribution
Male 15,449 (49.6%)
Female 14,991 (48.1%)
Unknown 610 (2.0%)
Mixed 92 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1,010 | |
| 2011 | 1,264 | |
| 2012 | 1,714 | |
| 2013 | 1,633 | |
| 2014 | 1,875 | |
| 2015 | 2,083 | |
| 2016 | 2,278 | |
| 2017 | 2,388 | |
| 2018 | 2,289 | |
| 2019 | 2,277 | |
| 2020 | 2,181 | |
| 2021 | 2,067 | |
| 2022 | 1,977 | |
| 2023 | 2,124 | |
| 2024 | 2,463 | |
| 2025 | 1,519 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #6 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.