Total Reports
31,142
FDA CVM filings
Dog /
FDA CVM · 2025 release 31,142 reports on file
Shepherd Dog - German - FDA Adverse Event Profile
Adverse-event records for Shepherd Dog - German (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 31,142 reports on file, Shepherd Dog - German sits at #6 among dog breeds by volume; death-coded share is 4.3% (1,347 reports).
- #6
- most-reported dog breed
- 4.3%
- death-coded report share
- 4,509
- Vomiting - top reaction
- 4.5 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
1,347
of 31,142 reports
Death Rate
4.3%
death-coded share
Avg Age at Report
4.5 yr
33.0 kg avg weight
Death-Coded Outcome Share
Shepherd Dog - German death-coded reports 4.3%
Cross-breed median
4.3% of 31,142 shepherd dog - german reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 33.0 kg (72.8 lbs)
Top Reported Reactions
Vomiting 4,509
Lack of efficacy (endoparasite) - heartworm 4,371
INEFFECTIVE, HEARTWORM LARVAE 3,122
Diarrhoea 2,315
Emesis 1,922
Lethargy (see also Central nervous system depression in 'Neurological') 1,860
Lack of efficacy - NOS 1,834
Lack of efficacy (endoparasite) - hookworm 1,556
Lack of efficacy (ectoparasite) - flea 1,371
Digestive tract disorder NOS 879
Seizure NOS 833
Cardiac disorder NOS 825
Anorexia 823
Lack of efficacy (ectoparasite) - tick NOS 752
Death 670
Most Referenced Drugs
Milbemycin Oxime + Spinosad 5,496
Ivermectin + Pyrantel As Pamoate Salt 4,912
Afoxolaner 2,006
Pyrantel Pamoate;Sarolaner 1,986
Milbemycin Oxime + Praziquantel 1,894
Moxidectin 1,655
Spinosad 1,270
Fluralaner Chew Tablets 1,151
Oclacitinib Maleate 1,105
Bedinvetmab 975
Carprofen 894
Fluralaner 13.64% 12-Week Chew 883
Melarsomine Dihydrochloride 577
Sarolaner 540
Ivermectin, Pyrantel 515
Outcome Breakdown
Outcome Unknown
10,451 (35.6%)
Ongoing
8,275 (28.2%)
Recovered/Normal
7,358 (25.1%)
Recovered with Sequela
1,889 (6.4%)
Died
790 (2.7%)
Euthanized
557 (1.9%)
Gender Distribution
Male 15,449 (49.6%)
Female 14,991 (48.1%)
Unknown 610 (2.0%)
Mixed 92 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1,010 | |
| 2011 | 1,264 | |
| 2012 | 1,714 | |
| 2013 | 1,633 | |
| 2014 | 1,875 | |
| 2015 | 2,083 | |
| 2016 | 2,278 | |
| 2017 | 2,388 | |
| 2018 | 2,289 | |
| 2019 | 2,277 | |
| 2020 | 2,181 | |
| 2021 | 2,067 | |
| 2022 | 1,977 | |
| 2023 | 2,124 | |
| 2024 | 2,463 | |
| 2025 | 1,519 | |
Shepherd Dog - German Pet Health Insights
Shepherd Dog - German accounts for 31,142 FDA adverse event reports, ranking #6 by volume among dog breeds, with 1,347 reports (4.3%) coded as a death outcome. Mean age at report: 4.5 years, average weight 33.0 kg (72.8 lbs).
Top reported signs: Vomiting (4,509), Lack of efficacy (endoparasite) - heartworm (4,371), INEFFECTIVE, HEARTWORM LARVAE (3,122). Most-referenced drug: Milbemycin Oxime + Spinosad (5,496 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (4,912) and Afoxolaner (2,006).
Outcome coding on 29,320 status-recorded reports is dominated by Outcome Unknown (35.6%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Shepherd Dog - German? ▼
There are 31,142 adverse event reports involving Shepherd Dog - German in the FDA database, with 1,347 reports involving death (4.3% death rate). Shepherd Dog - German ranks #6 by report volume.
What are the most common adverse reactions reported for Shepherd Dog - German? ▼
The most commonly reported adverse reactions for Shepherd Dog - German are Vomiting (4,509 reports), Lack of efficacy (endoparasite) - heartworm (4,371 reports), INEFFECTIVE, HEARTWORM LARVAE (3,122 reports), Diarrhoea (2,315 reports), Emesis (1,922 reports).
What drugs are most frequently associated with Shepherd Dog - German adverse events? ▼
The drugs most frequently referenced in Shepherd Dog - German adverse event reports are Milbemycin Oxime + Spinosad (5,496 reports), Ivermectin + Pyrantel As Pamoate Salt (4,912 reports), Afoxolaner (2,006 reports), Pyrantel Pamoate;Sarolaner (1,986 reports), Milbemycin Oxime + Praziquantel (1,894 reports).
What is the average age of Shepherd Dog - German in adverse event reports? ▼
The average age of Shepherd Dog - German at the time of adverse event reports is 4.5 years, with an average weight of 33.0 kg (72.8 lbs).
Does a high number of adverse event reports mean Shepherd Dog - German is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Shepherd Dog - German safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.