Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
357
Total Reports
13
Deaths Reported
360.0%
Death Rate
6.1 yr
Avg Age at Report
Average weight at time of report: 5.3 kg (11.7 lbs)
Top Reported Reactions
Vomiting 69
Lethargy (see also Central nervous system depression in 'Neurological') 57
Lack of efficacy (ectoparasite) - flea 51
Diarrhoea 36
Seizure NOS 27
Emesis 24
Anorexia 22
Lack of efficacy - NOS 22
Behavioural disorder NOS 16
Pruritus 15
Panting 14
Not eating 13
Ataxia 12
Shaking 11
Elevated blood urea nitrogen (BUN) 10
Most Referenced Drugs
Milbemycin Oxime + Spinosad 72
Spinosad 50
Afoxolaner 30
Ivermectin + Pyrantel As Pamoate Salt 24
Pimobendan 18
Nitenpyram 12
Pyrantel Pamoate;Sarolaner 12
Bedinvetmab 12
Imidacloprid + Moxidectin 10
Carprofen 9
Moxidectin 8
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 8
Trilostane 8
Milbemycin Oxime 7
Oclacitinib Maleate 7
Outcome Breakdown
Recovered/Normal
123 (38.3%)
Outcome Unknown
119 (37.1%)
Ongoing
57 (17.8%)
Died
10 (3.1%)
Recovered with Sequela
9 (2.8%)
Euthanized
3 (0.9%)
Gender Distribution
Female 172 (48.2%)
Male 169 (47.3%)
Unknown 16 (4.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 20 | |
| 2011 | 22 | |
| 2012 | 38 | |
| 2013 | 21 | |
| 2014 | 34 | |
| 2015 | 29 | |
| 2016 | 39 | |
| 2017 | 28 | |
| 2018 | 14 | |
| 2019 | 21 | |
| 2020 | 19 | |
| 2021 | 9 | |
| 2022 | 12 | |
| 2023 | 19 | |
| 2024 | 19 | |
| 2025 | 13 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #155 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.