Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
730
Total Reports
35
Deaths Reported
480.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 15.0 kg (33.1 lbs)
Top Reported Reactions
Vomiting 137
Lethargy (see also Central nervous system depression in 'Neurological') 76
Diarrhoea 69
Lack of efficacy (endoparasite) - hookworm 47
Lack of efficacy - NOS 45
Anorexia 41
Emesis 39
Lack of efficacy (endoparasite) - heartworm 35
Lack of efficacy (ectoparasite) - flea 34
Lack of efficacy (endoparasite) - whipworm 29
Seizure NOS 28
Behavioural disorder NOS 27
Loose stool 25
Not eating 23
Death by euthanasia 20
Most Referenced Drugs
Milbemycin Oxime + Spinosad 121
Ivermectin + Pyrantel As Pamoate Salt 79
Spinosad 45
Afoxolaner 44
Pyrantel Pamoate;Sarolaner 40
Milbemycin Oxime + Praziquantel 31
Pimobendan 26
Moxidectin 24
Bedinvetmab 24
Fluralaner Chew Tablets 23
Maropitant Citrate 22
Sarolaner 21
Oclacitinib Maleate 20
Carprofen 19
Prednisone 18
Outcome Breakdown
Outcome Unknown
254 (36.7%)
Recovered/Normal
224 (32.3%)
Ongoing
164 (23.7%)
Euthanized
21 (3.0%)
Recovered with Sequela
16 (2.3%)
Died
14 (2.0%)
Gender Distribution
Female 413 (56.6%)
Male 290 (39.7%)
Unknown 25 (3.4%)
Mixed 2 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 23 | |
| 2011 | 29 | |
| 2012 | 45 | |
| 2013 | 38 | |
| 2014 | 43 | |
| 2015 | 51 | |
| 2016 | 57 | |
| 2017 | 49 | |
| 2018 | 60 | |
| 2019 | 55 | |
| 2020 | 41 | |
| 2021 | 48 | |
| 2022 | 61 | |
| 2023 | 55 | |
| 2024 | 43 | |
| 2025 | 32 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #120 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.