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Breed profile · FDA CVM July 2026 extract

Setter - English adverse-event record

Adverse-event filings for Setter - English (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#101 of 510
by report volume (all breeds)
1,258
FDA CVM reports on file
3.4%
death-coded share of reports
#210 of 275
by death-coded share (≥50 reports)

How the 1,258 reports break down

By recorded gender -- every report on file for Setter - English, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 94 70.5 47 23.5 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Setter - English drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Setter - English ranks #101 of 510 by total reports (1,258) and #210 of 275 by death-coded share (3.4%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#101
This breed, reports of 510
#210
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Setter - English has 1,258 reports now versus 1,236 in that prior snapshot: 22 more (1.8%).

Report change
+22
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Setter - English changes

Total Reports

1,258

High report volume

Deaths Reported

43

of 1,258 reports

Death-coded share of reports

3.4%

Lowest death-coded share

Avg Age at Report

6.4 yr

23.0 kg avg weight

Breed Safety Scorecard

C (59/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate B+
3.4%

Share of reports coded as a fatality

Euthanasia rate A-
1.5%

Share of reports resulting in euthanasia

Full recovery rate F
22.6%

Share of reports coded "Recovered/Normal"

5-year trend D
+13%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Setter - English death-coded reports 3.4%
Cross-breed median

3.4% of 1,258 setter - english reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Setter - English's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

3% 24th percentile Higher share than 24% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Setter - English 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 23.0 kg (50.7 lbs)

Top Reported Reactions

Vomiting 167
Lack of efficacy (endoparasite) - hookworm 114
INEFFECTIVE, HEARTWORM LARVAE 110
Diarrhoea 109
Lack of efficacy (endoparasite) - heartworm 104
Lethargy (see also Central nervous system depression in 'Neurological') 75
Lack of efficacy - NOS 69
Digestive tract disorder NOS 57
Anorexia 47
Emesis 46
Lack of efficacy (ectoparasite) - tick NOS 45
INEFFECTIVE, ASCARIDS NOS 44
Seizure NOS 36
Lack of efficacy (endoparasite) - whipworm 35
Cardiac disorder NOS 34

Most Referenced Drugs

Ivermectin + Pyrantel As Pamoate Salt 202
Milbemycin Oxime + Spinosad 113
Milbemycin Oxime + Praziquantel 100
Afoxolaner 90
Pyrantel Pamoate;Sarolaner 76
Moxidectin 72
Oclacitinib Maleate 51
Carprofen 49
Fluralaner Chew Tablets 41
Sarolaner 39
Fluralaner 13.64% 12-Week Chew 38
Spinosad 36
Bedinvetmab 34
Milbemycin 29
Ivermectin, Pyrantel 22

Outcome Breakdown

Outcome Unknown
415 (36.2%)
Ongoing
350 (30.5%)
Recovered/Normal
284 (24.8%)
Recovered with Sequela
55 (4.8%)
Died
24 (2.1%)
Euthanized
19 (1.7%)

Gender Distribution

Female 639 (50.8%)
Male 597 (47.5%)
Unknown 18 (1.4%)
Mixed 4 (0.3%)

Reports by Year

Year Reports Trend
2010 62
2011 61
2012 68
2013 68
2014 67
2015 79
2016 91
2017 95
2018 84
2019 88
2020 75
2021 71
2022 71
2023 94
2024 87
2025 80
2026 17

Setter - English: low death-coded share in the FDA CVM extract

Signature read: 1,258 reports place Setter - English in the upper third of breed filing volume (#101 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Setter - English sits at #101 of 510 by report volume among all breeds and #85 of 298 among dog breeds, with 1,258 reports and 43 (3.4%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #210 of 275. Mean age at report: 6.4 years, average weight 23.0 kg (50.7 lbs).

Top reported signs: Vomiting (167), Lack of efficacy (endoparasite) - hookworm (114), INEFFECTIVE, HEARTWORM LARVAE (110). Most-referenced drug: Ivermectin + Pyrantel As Pamoate Salt (202 reports), followed by Milbemycin Oxime + Spinosad (113) and Milbemycin Oxime + Praziquantel (100).

Outcome coding on 1,147 status-recorded reports is dominated by Outcome Unknown (36.2%). Annual submissions ranged 17-2,026 across 17 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Coonhound (unspecified)
1,263 reports · 3.1% death-coded
Corgi - Welsh Cardigan
1,236 reports · 3.3% death-coded
Saint Bernard Dog
1,292 reports · 7.7% death-coded
Newfoundland
1,299 reports · 7.0% death-coded
Shar Pei
1,304 reports · 7.5% death-coded
Shepherd Dog (unspecified)
1,313 reports · 3.3% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Setter - English drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (3.4% death-coded here).

American Curl Shorthair 3.5% · Cat Oriental 3.1% · Cat Birman (Sacred Birman) 3.1% · Cat British cat 3.8% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (23.0 kg here).

Crossbred Caprine/goat 21.7 kg · Goat Mixed (Sheep) 24.9 kg · Sheep Pygmy 20.3 kg · Goat Wild cat 14.5 kg · Cat

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Setter - English? ▼
There are 1,258 adverse event reports involving Setter - English in the FDA database, of which 43 were death-coded (3.4% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Setter - English ranks #101 of 510 by report volume among all breeds PlainBreed indexes (#85 of 298 among dog breeds).
Where does Setter - English sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Setter - English is #101 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #85 of 298. Among breeds with at least 50 reports, its death-coded share ranks #210 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Setter - English? ▼
The most commonly reported adverse reactions for Setter - English are Vomiting (167 reports), Lack of efficacy (endoparasite) - hookworm (114 reports), INEFFECTIVE, HEARTWORM LARVAE (110 reports), Diarrhoea (109 reports), Lack of efficacy (endoparasite) - heartworm (104 reports).
What drugs are most frequently associated with Setter - English adverse events? ▼
The drugs most frequently referenced in Setter - English adverse event reports are Ivermectin + Pyrantel As Pamoate Salt (202 reports), Milbemycin Oxime + Spinosad (113 reports), Milbemycin Oxime + Praziquantel (100 reports), Afoxolaner (90 reports), Pyrantel Pamoate;Sarolaner (76 reports).
What is the average age of Setter - English in adverse event reports? ▼
The average age of Setter - English at the time of adverse event reports is 6.4 years, with an average weight of 23.0 kg (50.7 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Setter - English (Dog), extract as of July 2026 extract. 1,258 reports · 43 death-coded (3.4% of reports, not a mortality rate) · #101 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →