Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,210
Total Reports
43
Deaths Reported
360.0%
Death Rate
6.4 yr
Avg Age at Report
Average weight at time of report: 23.0 kg (50.7 lbs)
Top Reported Reactions
Vomiting 164
INEFFECTIVE, HEARTWORM LARVAE 110
Lack of efficacy (endoparasite) - hookworm 104
Diarrhoea 104
Lack of efficacy (endoparasite) - heartworm 99
Lethargy (see also Central nervous system depression in 'Neurological') 75
Lack of efficacy - NOS 68
Digestive tract disorder NOS 56
Emesis 46
Anorexia 45
INEFFECTIVE, ASCARIDS NOS 44
Lack of efficacy (ectoparasite) - tick NOS 44
Seizure NOS 36
Lack of efficacy (endoparasite) - whipworm 34
Cardiac disorder NOS 34
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 200
Milbemycin Oxime + Spinosad 113
Milbemycin Oxime + Praziquantel 97
Afoxolaner 90
Moxidectin 64
Pyrantel Pamoate;Sarolaner 64
Oclacitinib Maleate 50
Carprofen 45
Fluralaner Chew Tablets 41
Sarolaner 38
Spinosad 36
Fluralaner 13.64% 12-Week Chew 36
Milbemycin 29
Bedinvetmab 24
Ivermectin, Pyrantel 22
Outcome Breakdown
Outcome Unknown
401 (36.5%)
Ongoing
320 (29.1%)
Recovered/Normal
280 (25.5%)
Recovered with Sequela
55 (5.0%)
Died
24 (2.2%)
Euthanized
19 (1.7%)
Gender Distribution
Female 608 (50.2%)
Male 580 (47.9%)
Unknown 18 (1.5%)
Mixed 4 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 62 | |
| 2011 | 61 | |
| 2012 | 68 | |
| 2013 | 68 | |
| 2014 | 67 | |
| 2015 | 79 | |
| 2016 | 91 | |
| 2017 | 95 | |
| 2018 | 84 | |
| 2019 | 88 | |
| 2020 | 75 | |
| 2021 | 71 | |
| 2022 | 71 | |
| 2023 | 94 | |
| 2024 | 87 | |
| 2025 | 49 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #101 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.