Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
346
Total Reports
20
Deaths Reported
580.0%
Death Rate
4.7 yr
Avg Age at Report
Average weight at time of report: 34.0 kg (75.0 lbs)
Top Reported Reactions
Vomiting 65
Diarrhoea 34
Lethargy (see also Central nervous system depression in 'Neurological') 31
Emesis 24
Lack of efficacy (ectoparasite) - flea 24
Lack of efficacy - NOS 23
Seizure NOS 21
Lack of efficacy (endoparasite) - hookworm 20
Other abnormal test result NOS 14
Death by euthanasia 12
Lethargy (see also Central nervous system depression in Neurological) 12
Digestive tract disorder NOS 11
Weight loss 11
Lack of efficacy (endoparasite) - heartworm 11
Emesis (multiple) 10
Most Referenced Drugs
Milbemycin Oxime + Spinosad 55
Ivermectin + Pyrantel As Pamoate Salt 33
Pyrantel Pamoate;Sarolaner 31
Fluralaner Chew Tablets 22
Moxidectin 22
Carprofen 18
Spinosad 18
Afoxolaner 18
Milbemycin Oxime + Praziquantel 10
Fluralaner 13.64% 12-Week Chew 10
Bedinvetmab 9
Oclacitinib Maleate 8
Gabapentin 8
Lotilaner 8
Trilostane 7
Outcome Breakdown
Outcome Unknown
125 (36.1%)
Ongoing
96 (27.7%)
Recovered/Normal
95 (27.5%)
Euthanized
12 (3.5%)
Recovered with Sequela
10 (2.9%)
Died
8 (2.3%)
Gender Distribution
Male 186 (53.8%)
Female 141 (40.8%)
Unknown 18 (5.2%)
Mixed 1 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 6 | |
| 2012 | 25 | |
| 2013 | 33 | |
| 2014 | 19 | |
| 2015 | 18 | |
| 2016 | 28 | |
| 2017 | 28 | |
| 2018 | 24 | |
| 2019 | 16 | |
| 2020 | 23 | |
| 2021 | 22 | |
| 2022 | 27 | |
| 2023 | 27 | |
| 2024 | 37 | |
| 2025 | 13 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #158 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.