Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
119
Total Reports
8
Deaths Reported
670.0%
Death Rate
5.9 yr
Avg Age at Report
Average weight at time of report: 25.8 kg (56.9 lbs)
Top Reported Reactions
Vomiting 32
Diarrhoea 10
Seizure NOS 9
Emesis 8
Behavioural disorder NOS 7
Lethargy (see also Central nervous system depression in 'Neurological') 7
Lack of efficacy (bacteria) - NOS 6
Hypersalivation 5
INEFFECTIVE, HEARTWORM LARVAE 4
Anorexia 4
Death by euthanasia 4
Lack of efficacy - NOS 4
Vocalisation 4
Elevated blood urea nitrogen (BUN) 4
Death 4
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 19
Afoxolaner 11
Milbemycin Oxime + Spinosad 8
Carprofen 7
Fluralaner Chew Tablets 7
Selamectin 6
Milbemycin Oxime + Praziquantel 6
Pyrantel Pamoate;Sarolaner 6
Lotilaner 5
Bedinvetmab 5
Isoflurane 4
Prednisone 4
Sarolaner 4
Ivermectin, Pyrantel 3
Milbemycin Oxime 3
Outcome Breakdown
Recovered/Normal
39 (34.8%)
Outcome Unknown
36 (32.1%)
Ongoing
28 (25.0%)
Died
5 (4.5%)
Euthanized
3 (2.7%)
Recovered with Sequela
1 (0.9%)
Gender Distribution
Male 61 (51.3%)
Female 52 (43.7%)
Unknown 5 (4.2%)
Mixed 1 (0.8%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 3 | |
| 2012 | 11 | |
| 2013 | 6 | |
| 2014 | 6 | |
| 2015 | 4 | |
| 2016 | 5 | |
| 2017 | 13 | |
| 2018 | 10 | |
| 2019 | 10 | |
| 2020 | 12 | |
| 2021 | 10 | |
| 2022 | 6 | |
| 2023 | 8 | |
| 2024 | 9 | |
| 2025 | 3 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #223 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.