Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
30,657
Total Reports
1,284
Deaths Reported
420.0%
Death Rate
5.8 yr
Avg Age at Report
Average weight at time of report: 4.8 kg (10.6 lbs)
Top Reported Reactions
Vomiting 6,728
Lack of efficacy (ectoparasite) - flea 3,703
Lethargy (see also Central nervous system depression in 'Neurological') 3,541
Emesis 2,877
Diarrhoea 2,146
Seizure NOS 1,588
Lack of efficacy - NOS 1,428
Anorexia 1,289
Lack of efficacy (endoparasite) - heartworm 1,055
Behavioural disorder NOS 946
Shaking 938
Ataxia 884
Not eating 833
Pruritus 830
Overdose 813
Most Referenced Drugs
Milbemycin Oxime + Spinosad 6,085
Spinosad 3,541
Ivermectin + Pyrantel As Pamoate Salt 1,943
Afoxolaner 1,854
Moxidectin 1,700
Pyrantel Pamoate;Sarolaner 1,400
Fluralaner Chew Tablets 1,351
Nitenpyram 1,071
Fluralaner 13.64% 12-Week Chew 910
Sarolaner 765
Milbemycin Oxime + Praziquantel 734
Trilostane 718
Oclacitinib Maleate 691
Selamectin 652
Imidacloprid + Moxidectin 603
Outcome Breakdown
Recovered/Normal
10,456 (36.3%)
Outcome Unknown
9,299 (32.3%)
Ongoing
6,704 (23.3%)
Recovered with Sequela
1,059 (3.7%)
Died
860 (3.0%)
Euthanized
424 (1.5%)
Gender Distribution
Female 15,794 (51.5%)
Male 13,912 (45.4%)
Unknown 839 (2.7%)
Mixed 112 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 991 | |
| 2011 | 1,458 | |
| 2012 | 2,165 | |
| 2013 | 2,224 | |
| 2014 | 2,323 | |
| 2015 | 2,431 | |
| 2016 | 2,298 | |
| 2017 | 2,455 | |
| 2018 | 2,127 | |
| 2019 | 2,109 | |
| 2020 | 1,956 | |
| 2021 | 1,816 | |
| 2022 | 1,684 | |
| 2023 | 1,660 | |
| 2024 | 1,804 | |
| 2025 | 1,156 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #7 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.