Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
7,307
Total Reports
320
Deaths Reported
440.0%
Death Rate
6.3 yr
Avg Age at Report
Average weight at time of report: 8.0 kg (17.6 lbs)
Top Reported Reactions
Vomiting 1,647
Lethargy (see also Central nervous system depression in 'Neurological') 890
Diarrhoea 647
Emesis 611
Lack of efficacy (endoparasite) - hookworm 569
Lack of efficacy - NOS 460
Lack of efficacy (ectoparasite) - flea 403
Seizure NOS 368
Digestive tract disorder NOS 330
Anorexia 295
Other abnormal test result NOS 240
Emesis (multiple) 232
Behavioural disorder NOS 224
Not eating 192
Elevated serum alkaline phosphatase (SAP) 191
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,457
Ivermectin + Pyrantel As Pamoate Salt 792
Afoxolaner 562
Pyrantel Pamoate;Sarolaner 425
Moxidectin 372
Fluralaner Chew Tablets 363
Spinosad 309
Trilostane 294
Oclacitinib Maleate 272
Fluralaner 13.64% 12-Week Chew 251
Milbemycin Oxime + Praziquantel 241
Insulin Injectable Vial 213
Sarolaner 151
Maropitant Citrate 134
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 127
Outcome Breakdown
Recovered/Normal
2,597 (35.5%)
Outcome Unknown
2,371 (32.5%)
Ongoing
1,750 (24.0%)
Recovered with Sequela
268 (3.7%)
Euthanized
182 (2.5%)
Died
138 (1.9%)
Gender Distribution
Female 3,637 (49.8%)
Male 3,527 (48.3%)
Unknown 118 (1.6%)
Mixed 25 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 8 | |
| 2011 | 115 | |
| 2012 | 444 | |
| 2013 | 573 | |
| 2014 | 662 | |
| 2015 | 681 | |
| 2016 | 652 | |
| 2017 | 612 | |
| 2018 | 558 | |
| 2019 | 494 | |
| 2020 | 485 | |
| 2021 | 462 | |
| 2022 | 390 | |
| 2023 | 391 | |
| 2024 | 457 | |
| 2025 | 323 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #29 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.