Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
6,412
Total Reports
521
Deaths Reported
810.0%
Death Rate
4.5 yr
Avg Age at Report
Average weight at time of report: 38.6 kg (85.1 lbs)
Top Reported Reactions
Vomiting 1,299
Lack of efficacy (endoparasite) - heartworm 596
INEFFECTIVE, HEARTWORM LARVAE 594
Lethargy (see also Central nervous system depression in 'Neurological') 585
Emesis 498
Diarrhoea 485
Lack of efficacy - NOS 384
Anorexia 321
Death 266
Lack of efficacy (endoparasite) - hookworm 260
Other abnormal test result NOS 225
Death by euthanasia 220
Lack of efficacy (ectoparasite) - flea 217
Seizure NOS 215
Digestive tract disorder NOS 200
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,253
Ivermectin + Pyrantel As Pamoate Salt 896
Moxidectin 346
Afoxolaner 330
Pyrantel Pamoate;Sarolaner 325
Spinosad 324
Milbemycin Oxime + Praziquantel 307
Carprofen 300
Fluralaner Chew Tablets 223
Bedinvetmab 193
Melarsomine Dihydrochloride 167
Fluralaner 13.64% 12-Week Chew 141
Deracoxib 127
Gabapentin 124
Ivermectin, Pyrantel 112
Outcome Breakdown
Outcome Unknown
1,892 (32.2%)
Recovered/Normal
1,723 (29.3%)
Ongoing
1,421 (24.2%)
Died
330 (5.6%)
Recovered with Sequela
320 (5.4%)
Euthanized
191 (3.2%)
Gender Distribution
Male 3,265 (50.9%)
Female 2,976 (46.4%)
Unknown 144 (2.2%)
Mixed 27 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 308 | |
| 2011 | 384 | |
| 2012 | 478 | |
| 2013 | 455 | |
| 2014 | 449 | |
| 2015 | 490 | |
| 2016 | 467 | |
| 2017 | 494 | |
| 2018 | 400 | |
| 2019 | 418 | |
| 2020 | 382 | |
| 2021 | 379 | |
| 2022 | 292 | |
| 2023 | 342 | |
| 2024 | 430 | |
| 2025 | 244 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #34 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.