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Breed profile · FDA CVM July 2026 extract

Collie - Smooth-haired adverse-event record

Adverse-event filings for Collie - Smooth-haired (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#202 of 510
by report volume (all breeds)
160
FDA CVM reports on file
11.3%
death-coded share of reports
#41 of 275
by death-coded share (≥50 reports)

How the 160 reports break down

By recorded gender -- every report on file for Collie - Smooth-haired, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 16 12 8 4 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Collie - Smooth-haired drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Collie - Smooth-haired ranks #202 of 510 by total reports (160) and #41 of 275 by death-coded share (11.3%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#202
This breed, reports of 510
#41
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Collie - Smooth-haired has 160 reports now versus 155 in that prior snapshot: 5 more (3.2%).

Report change
+5
Death-coded reports
+1
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Collie - Smooth-haired changes

Total Reports

160

Above-median volume

Deaths Reported

18

of 160 reports

Death-coded share of reports

11.3%

High death-coded share

Avg Age at Report

6.5 yr

26.0 kg avg weight

Death-Coded Outcome Share

Collie - Smooth-haired death-coded reports 11.3%
Cross-breed median

11.3% of 160 collie - smooth-haired reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Collie - Smooth-haired's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

11% 85th percentile Higher share than 85% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). Below this entry. 20%–25%: 2 indexed breeds (1%). Below this entry. 25%–30%: 3 indexed breeds (1%). Below this entry. 30%–35%: 4 indexed breeds (1%). Below this entry. 35%–40%: 5 indexed breeds (2%). Below this entry. 40%–45%: 6 indexed breeds (2%). Below this entry. 45%–50%: 3 indexed breeds (1%). Below this entry. 50%–55%: 7 indexed breeds (3%). Below this entry. 55%–60%: 7 indexed breeds (3%). Below this entry. 60%–65%: 21 indexed breeds (8%). Below this entry. 65%–70%: 11 indexed breeds (4%). Below this entry. 70%–75%: 15 indexed breeds (5%). Below this entry. 75%–80%: 13 indexed breeds (5%). Below this entry. 80%–85%: 11 indexed breeds (4%). Below this entry. 85%–90%: 12 indexed breeds (4%). Below this entry. 90%–95%: 12 indexed breeds (4%). Below this entry. 95%–100%: 142 indexed breeds (52%). This entry sits in this band. Collie - Smooth-haired 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 26.0 kg (57.3 lbs)

Top Reported Reactions

Vomiting 22
Lethargy (see also Central nervous system depression in 'Neurological') 19
Seizure NOS 18
Emesis 14
Diarrhoea 14
Death by euthanasia 12
Elevated alanine aminotransferase (ALT) 10
Decreased appetite 9

Most Referenced Drugs

Milbemycin Oxime + Spinosad 41
Trilostane 30
Milbemycin Oxime + Praziquantel 10
Milbemycin Oxime 9
Carprofen 9
Oclacitinib Maleate 7
Sarolaner 7
Moxidectin 7

Outcome Breakdown

Recovered/Normal
46 (28.7%)
Outcome Unknown
44 (27.5%)
Ongoing
44 (27.5%)
Euthanized
13 (8.1%)
Recovered with Sequela
8 (5.0%)
Died
5 (3.1%)

Gender Distribution

Female 82 (51.2%)
Male 78 (48.8%)

Reports by Year

Year Reports Trend
2011 3
2012 12
2013 11
2014 14
2015 9
2016 11
2017 14
2018 12
2019 10
2020 16
2021 13
2022 9
2023 5
2024 9
2025 9
2026 3

Collie - Smooth-haired: high death-coded share in the FDA CVM extract

Signature read: Collie - Smooth-haired's 11.3% death-coded share is in the upper third of the ≥50-report cohort (median 4.8%). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Collie - Smooth-haired sits at #202 of 510 by report volume among all breeds and #156 of 298 among dog breeds, with 160 reports and 18 (11.3%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #41 of 275. Mean age at report: 6.5 years, average weight 26.0 kg (57.3 lbs).

Top reported signs: Vomiting (22), Lethargy (see also Central nervous system depression in 'Neurological') (19), Seizure NOS (18). Most-referenced drug: Milbemycin Oxime + Spinosad (41 reports), followed by Trilostane (30) and Milbemycin Oxime + Praziquantel (10).

Outcome coding on 160 status-recorded reports is dominated by Recovered/Normal (28.7%). Annual submissions ranged 3-2,026 across 16 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Terrier - Manchester
162 reports · 4.9% death-coded
Australian Kelpie
164 reports · 2.4% death-coded
Dachshund - Standard Wire-haired
156 reports · 2.6% death-coded
Spaniel - Springer Welsh
164 reports · 3.7% death-coded
Setter (unspecified)
166 reports · 4.8% death-coded
Terrier - Australian
154 reports · 2.6% death-coded

Nationwide breeds with similar profiles

Two openFDA-derived peer sets for Collie - Smooth-haired, both outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (11.3% death-coded here).

Manx 11.3% · Cat Burmese 11.4% · Cat Quarter Horse 11.1% · Horse Percheron 11.5% · Horse

Similar average weight

Nearest other-species breeds by reported average weight (26.0 kg here).

Mixed (Sheep) 24.9 kg · Sheep Crossbred Caprine/goat 21.7 kg · Goat Pygmy 20.3 kg · Goat Fish (other) 32.4 kg · Fish

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Collie - Smooth-haired? ▼
There are 160 adverse event reports involving Collie - Smooth-haired in the FDA database, of which 18 were death-coded (11.3% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Collie - Smooth-haired ranks #202 of 510 by report volume among all breeds PlainBreed indexes (#156 of 298 among dog breeds).
Where does Collie - Smooth-haired sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Collie - Smooth-haired is #202 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #156 of 298. Among breeds with at least 50 reports, its death-coded share ranks #41 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Collie - Smooth-haired? ▼
The most commonly reported adverse reactions for Collie - Smooth-haired are Vomiting (22 reports), Lethargy (see also Central nervous system depression in 'Neurological') (19 reports), Seizure NOS (18 reports), Emesis (14 reports), Diarrhoea (14 reports).
What drugs are most frequently associated with Collie - Smooth-haired adverse events? ▼
The drugs most frequently referenced in Collie - Smooth-haired adverse event reports are Milbemycin Oxime + Spinosad (41 reports), Trilostane (30 reports), Milbemycin Oxime + Praziquantel (10 reports), Milbemycin Oxime (9 reports), Carprofen (9 reports).
What is the average age of Collie - Smooth-haired in adverse event reports? ▼
The average age of Collie - Smooth-haired at the time of adverse event reports is 6.5 years, with an average weight of 26.0 kg (57.3 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Collie - Smooth-haired (Dog), extract as of July 2026 extract. 160 reports · 18 death-coded (11.3% of reports, not a mortality rate) · #202 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →