Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
152
Total Reports
17
Deaths Reported
1120.0%
Death Rate
6.5 yr
Avg Age at Report
Average weight at time of report: 26.1 kg (57.6 lbs)
Top Reported Reactions
Vomiting 22
Lethargy (see also Central nervous system depression in 'Neurological') 19
Seizure NOS 16
Emesis 14
Diarrhoea 14
Death by euthanasia 12
Elevated alanine aminotransferase (ALT) 10
Decreased appetite 9
Behavioural disorder NOS 9
Lack of efficacy - NOS 9
Not eating 9
Elevated serum alkaline phosphatase (SAP) 8
Weight loss 8
Inappropriate urination 6
Ataxia 6
Most Referenced Drugs
Milbemycin Oxime + Spinosad 41
Trilostane 29
Milbemycin Oxime 9
Carprofen 8
Oclacitinib Maleate 7
Milbemycin Oxime + Praziquantel 7
Moxidectin 7
Pyrantel Pamoate;Sarolaner 7
Selamectin 6
Sarolaner 6
Spinosad 5
Prednisone 5
Fluralaner Chew Tablets 5
Cyclosporine A 4
Gabapentin 4
Outcome Breakdown
Recovered/Normal
45 (29.6%)
Ongoing
41 (27.0%)
Outcome Unknown
41 (27.0%)
Euthanized
12 (7.9%)
Recovered with Sequela
8 (5.3%)
Died
5 (3.3%)
Gender Distribution
Female 78 (51.3%)
Male 74 (48.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 3 | |
| 2012 | 12 | |
| 2013 | 11 | |
| 2014 | 14 | |
| 2015 | 9 | |
| 2016 | 11 | |
| 2017 | 14 | |
| 2018 | 12 | |
| 2019 | 10 | |
| 2020 | 16 | |
| 2021 | 13 | |
| 2022 | 9 | |
| 2023 | 5 | |
| 2024 | 9 | |
| 2025 | 4 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #203 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.