Total Reports
152
FDA CVM filings
Dog /
FDA CVM · 2025 release 152 reports on file
Collie - Smooth-haired - FDA Adverse Event Profile
Adverse-event records for Collie - Smooth-haired (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Collie - Smooth-haired's FDA record: #203 most-reported dog breed, 152 total reports, 11.2% death-coded (17 reports).
- #203
- most-reported dog breed
- 11.2%
- death-coded report share
- 22
- Vomiting - top reaction
- 6.5 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
17
of 152 reports
Death Rate
11.2%
death-coded share
Avg Age at Report
6.5 yr
26.1 kg avg weight
Death-Coded Outcome Share
Collie - Smooth-haired death-coded reports 11.2%
Cross-breed median
11.2% of 152 collie - smooth-haired reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 26.1 kg (57.6 lbs)
Top Reported Reactions
Vomiting 22
Lethargy (see also Central nervous system depression in 'Neurological') 19
Seizure NOS 16
Emesis 14
Diarrhoea 14
Death by euthanasia 12
Elevated alanine aminotransferase (ALT) 10
Decreased appetite 9
Most Referenced Drugs
Milbemycin Oxime + Spinosad 41
Trilostane 29
Milbemycin Oxime 9
Carprofen 8
Oclacitinib Maleate 7
Milbemycin Oxime + Praziquantel 7
Moxidectin 7
Pyrantel Pamoate;Sarolaner 7
Outcome Breakdown
Recovered/Normal
45 (29.6%)
Ongoing
41 (27.0%)
Outcome Unknown
41 (27.0%)
Euthanized
12 (7.9%)
Recovered with Sequela
8 (5.3%)
Died
5 (3.3%)
Gender Distribution
Female 78 (51.3%)
Male 74 (48.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 3 | |
| 2012 | 12 | |
| 2013 | 11 | |
| 2014 | 14 | |
| 2015 | 9 | |
| 2016 | 11 | |
| 2017 | 14 | |
| 2018 | 12 | |
| 2019 | 10 | |
| 2020 | 16 | |
| 2021 | 13 | |
| 2022 | 9 | |
| 2023 | 5 | |
| 2024 | 9 | |
| 2025 | 4 | |
Collie - Smooth-haired Pet Health Insights
Collie - Smooth-haired accounts for 152 FDA adverse event reports, ranking #203 by volume among dog breeds, with 17 reports (11.2%) coded as a death outcome. Mean age at report: 6.5 years, average weight 26.1 kg (57.6 lbs).
Top reported signs: Vomiting (22), Lethargy (see also Central nervous system depression in 'Neurological') (19), Seizure NOS (16). Most-referenced drug: Milbemycin Oxime + Spinosad (41 reports), followed by Trilostane (29) and Milbemycin Oxime (9).
Outcome coding on 152 status-recorded reports is dominated by Recovered/Normal (29.6%). Annual submissions ranged 2,011-2,025 across 15 years on file.
Dog Breeds With a Similar Report Volume
Dachshund - Standard Wire-haired
152 reports · 2.6% death rate
Spitz (unspecified)
150 reports · 1.3% death rate
Spaniel - Springer Welsh
155 reports · 3.2% death rate
Terrier - Australian
149 reports · 2.7% death rate
Australian Kelpie
156 reports · 1.9% death rate
Terrier - Manchester
159 reports · 5.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Collie - Smooth-haired? ▼
There are 152 adverse event reports involving Collie - Smooth-haired in the FDA database, with 17 reports involving death (11.2% death rate). Collie - Smooth-haired ranks #203 by report volume.
What are the most common adverse reactions reported for Collie - Smooth-haired? ▼
The most commonly reported adverse reactions for Collie - Smooth-haired are Vomiting (22 reports), Lethargy (see also Central nervous system depression in 'Neurological') (19 reports), Seizure NOS (16 reports), Emesis (14 reports), Diarrhoea (14 reports).
What drugs are most frequently associated with Collie - Smooth-haired adverse events? ▼
The drugs most frequently referenced in Collie - Smooth-haired adverse event reports are Milbemycin Oxime + Spinosad (41 reports), Trilostane (29 reports), Milbemycin Oxime (9 reports), Carprofen (8 reports), Oclacitinib Maleate (7 reports).
What is the average age of Collie - Smooth-haired in adverse event reports? ▼
The average age of Collie - Smooth-haired at the time of adverse event reports is 6.5 years, with an average weight of 26.1 kg (57.6 lbs).
Does a high number of adverse event reports mean Collie - Smooth-haired is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Collie - Smooth-haired safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.