Total Reports
517
FDA CVM filings
Dog /
FDA CVM · 2025 release 517 reports on file
Spaniel - King Charles - FDA Adverse Event Profile
Adverse-event records for Spaniel - King Charles (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 517 reports on file, Spaniel - King Charles sits at #137 among dog breeds by volume; death-coded share is 3.1% (16 reports).
- #137
- most-reported dog breed
- 3.1%
- death-coded report share
- 121
- Vomiting - top reaction
- 5.0 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
16
of 517 reports
Death Rate
3.1%
death-coded share
Avg Age at Report
5.0 yr
9.0 kg avg weight
Death-Coded Outcome Share
Spaniel - King Charles death-coded reports 3.1%
Cross-breed median
3.1% of 517 spaniel - king charles reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 9.0 kg (19.8 lbs)
Top Reported Reactions
Vomiting 121
Emesis 81
Lethargy (see also Central nervous system depression in 'Neurological') 77
Diarrhoea 68
Digestive tract disorder NOS 36
Lack of efficacy - NOS 29
Lack of efficacy (ectoparasite) - flea 27
Seizure NOS 27
Most Referenced Drugs
Milbemycin Oxime + Spinosad 142
Ivermectin + Pyrantel As Pamoate Salt 69
Afoxolaner 65
Spinosad 46
Fluralaner Chew Tablets 25
Pimobendan 21
Trilostane 21
Polysulfated Glycosaminoglycan 21
Outcome Breakdown
Recovered/Normal
259 (50.5%)
Outcome Unknown
169 (32.9%)
Ongoing
52 (10.1%)
Recovered with Sequela
17 (3.3%)
Died
12 (2.3%)
Euthanized
4 (0.8%)
Gender Distribution
Female 249 (48.2%)
Male 244 (47.2%)
Unknown 19 (3.7%)
Mixed 5 (1.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 24 | |
| 2012 | 48 | |
| 2013 | 63 | |
| 2014 | 59 | |
| 2015 | 61 | |
| 2016 | 46 | |
| 2017 | 42 | |
| 2018 | 31 | |
| 2019 | 45 | |
| 2020 | 29 | |
| 2021 | 19 | |
| 2022 | 9 | |
| 2023 | 11 | |
| 2024 | 21 | |
| 2025 | 6 | |
Spaniel - King Charles Pet Health Insights
Spaniel - King Charles accounts for 517 FDA adverse event reports, ranking #137 by volume among dog breeds, with 16 reports (3.1%) coded as a death outcome. Mean age at report: 5.0 years, average weight 9.0 kg (19.8 lbs).
Top reported signs: Vomiting (121), Emesis (81), Lethargy (see also Central nervous system depression in 'Neurological') (77). Most-referenced drug: Milbemycin Oxime + Spinosad (142 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (69) and Afoxolaner (65).
Outcome coding on 513 status-recorded reports is dominated by Recovered/Normal (50.5%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Spaniel - King Charles? ▼
There are 517 adverse event reports involving Spaniel - King Charles in the FDA database, with 16 reports involving death (3.1% death rate). Spaniel - King Charles ranks #137 by report volume.
What are the most common adverse reactions reported for Spaniel - King Charles? ▼
The most commonly reported adverse reactions for Spaniel - King Charles are Vomiting (121 reports), Emesis (81 reports), Lethargy (see also Central nervous system depression in 'Neurological') (77 reports), Diarrhoea (68 reports), Digestive tract disorder NOS (36 reports).
What drugs are most frequently associated with Spaniel - King Charles adverse events? ▼
The drugs most frequently referenced in Spaniel - King Charles adverse event reports are Milbemycin Oxime + Spinosad (142 reports), Ivermectin + Pyrantel As Pamoate Salt (69 reports), Afoxolaner (65 reports), Spinosad (46 reports), Fluralaner Chew Tablets (25 reports).
What is the average age of Spaniel - King Charles in adverse event reports? ▼
The average age of Spaniel - King Charles at the time of adverse event reports is 5.0 years, with an average weight of 9.0 kg (19.8 lbs).
Does a high number of adverse event reports mean Spaniel - King Charles is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Spaniel - King Charles safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.