Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
517
Total Reports
16
Deaths Reported
310.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 9.0 kg (19.8 lbs)
Top Reported Reactions
Vomiting 121
Emesis 81
Lethargy (see also Central nervous system depression in 'Neurological') 77
Diarrhoea 68
Digestive tract disorder NOS 36
Lack of efficacy - NOS 29
Lack of efficacy (ectoparasite) - flea 27
Seizure NOS 27
Lack of efficacy (endoparasite) - hookworm 27
Not eating 18
INEFFECTIVE, HOOKS 14
Death 12
Behavioural disorder NOS 12
Pruritus 12
INEFFECTIVE, ASCARIDS NOS 12
Most Referenced Drugs
Milbemycin Oxime + Spinosad 142
Ivermectin + Pyrantel As Pamoate Salt 69
Afoxolaner 65
Spinosad 46
Fluralaner Chew Tablets 25
Pimobendan 21
Trilostane 21
Polysulfated Glycosaminoglycan 21
Fluralaner 13.64% 12-Week Chew 19
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 10
Milbemycin Oxime + Praziquantel 10
Milbemycin Oxime 8
Nitenpyram 8
Ivermectin 7
Lufenuron + Milbemycin Oxime 7
Outcome Breakdown
Recovered/Normal
259 (50.5%)
Outcome Unknown
169 (32.9%)
Ongoing
52 (10.1%)
Recovered with Sequela
17 (3.3%)
Died
12 (2.3%)
Euthanized
4 (0.8%)
Gender Distribution
Female 249 (48.2%)
Male 244 (47.2%)
Unknown 19 (3.7%)
Mixed 5 (1.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 24 | |
| 2012 | 48 | |
| 2013 | 63 | |
| 2014 | 59 | |
| 2015 | 61 | |
| 2016 | 46 | |
| 2017 | 42 | |
| 2018 | 31 | |
| 2019 | 45 | |
| 2020 | 29 | |
| 2021 | 19 | |
| 2022 | 9 | |
| 2023 | 11 | |
| 2024 | 21 | |
| 2025 | 6 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #137 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.