Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,859
Total Reports
153
Deaths Reported
400.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 23.0 kg (50.7 lbs)
Top Reported Reactions
Vomiting 728
Emesis 403
INEFFECTIVE, HEARTWORM LARVAE 359
Lack of efficacy (endoparasite) - heartworm 338
Lethargy (see also Central nervous system depression in 'Neurological') 326
Lack of efficacy - NOS 246
Lack of efficacy (endoparasite) - hookworm 243
Diarrhoea 214
Lack of efficacy (ectoparasite) - flea 162
Digestive tract disorder NOS 148
Anorexia 110
Cardiac disorder NOS 92
Other abnormal test result NOS 87
Weight loss 84
INEFFECTIVE, ASCARIDS NOS 82
Most Referenced Drugs
Milbemycin Oxime + Spinosad 864
Ivermectin + Pyrantel As Pamoate Salt 485
Spinosad 284
Pyrantel Pamoate;Sarolaner 178
Milbemycin Oxime + Praziquantel 168
Moxidectin 158
Afoxolaner 154
Oclacitinib Maleate 138
Fluralaner Chew Tablets 133
Carprofen 115
Ivermectin, Pyrantel 72
Fluralaner 13.64% 12-Week Chew 70
Trilostane 67
Selamectin 62
Milbemycin Oxime 62
Outcome Breakdown
Outcome Unknown
1,236 (35.3%)
Recovered/Normal
1,125 (32.1%)
Ongoing
806 (23.0%)
Recovered with Sequela
182 (5.2%)
Died
89 (2.5%)
Euthanized
65 (1.9%)
Gender Distribution
Male 1,986 (51.5%)
Female 1,796 (46.5%)
Unknown 69 (1.8%)
Mixed 8 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 192 | |
| 2011 | 255 | |
| 2012 | 350 | |
| 2013 | 303 | |
| 2014 | 324 | |
| 2015 | 288 | |
| 2016 | 296 | |
| 2017 | 284 | |
| 2018 | 238 | |
| 2019 | 223 | |
| 2020 | 207 | |
| 2021 | 184 | |
| 2022 | 178 | |
| 2023 | 186 | |
| 2024 | 220 | |
| 2025 | 131 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #51 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.