Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
5,792
Total Reports
238
Deaths Reported
410.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 20.1 kg (44.3 lbs)
Top Reported Reactions
Vomiting 1,244
Emesis 936
Lethargy (see also Central nervous system depression in 'Neurological') 593
Diarrhoea 425
Lack of efficacy - NOS 270
Lack of efficacy (endoparasite) - heartworm 227
Lack of efficacy (ectoparasite) - flea 216
INEFFECTIVE, HEARTWORM LARVAE 214
Anorexia 211
Seizure NOS 208
Lack of efficacy (endoparasite) - hookworm 162
Ataxia 156
Other abnormal test result NOS 152
Behavioural disorder NOS 143
Depression 128
Most Referenced Drugs
Spinosad 1,267
Milbemycin Oxime + Spinosad 866
Ivermectin + Pyrantel As Pamoate Salt 495
Afoxolaner 398
Trilostane 247
Melarsomine Dihydrochloride Injection 240
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 193
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 120
Milbemycin Oxime + Praziquantel 120
Fluralaner Chew Tablets 115
Pyrantel Pamoate;Sarolaner 111
Carprofen 107
Fluralaner 13.64% 12-Week Chew 107
Ivermectin 105
Polysulfated Glycosaminoglycan 99
Outcome Breakdown
Recovered/Normal
2,220 (43.0%)
Outcome Unknown
1,817 (35.2%)
Ongoing
655 (12.7%)
Recovered with Sequela
232 (4.5%)
Died
148 (2.9%)
Euthanized
90 (1.7%)
Gender Distribution
Female 2,656 (45.9%)
Male 2,577 (44.5%)
Unknown 521 (9.0%)
Mixed 38 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 350 | |
| 2011 | 1,011 | |
| 2012 | 1,549 | |
| 2013 | 371 | |
| 2014 | 207 | |
| 2015 | 194 | |
| 2016 | 189 | |
| 2017 | 210 | |
| 2018 | 201 | |
| 2019 | 187 | |
| 2020 | 204 | |
| 2021 | 215 | |
| 2022 | 252 | |
| 2023 | 215 | |
| 2024 | 254 | |
| 2025 | 183 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #36 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.