Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
564
Total Reports
24
Deaths Reported
430.0%
Death Rate
2.4 yr
Avg Age at Report
Average weight at time of report: 39.6 kg (87.3 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 98
Vomiting 94
Diarrhoea 45
Seizure NOS 37
Lethargy (see also Central nervous system depression in 'Neurological') 36
INEFFECTIVE, HEARTWORM LARVAE 34
Lack of efficacy (ectoparasite) - flea 32
Emesis 26
Underdose 25
Lack of efficacy - NOS 24
Lack of efficacy (endoparasite) - hookworm 23
Emesis (multiple) 18
Lack of efficacy (endoparasite) - roundworm NOS 18
INEFFECTIVE, ASCARIDS NOS 17
Death 15
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 155
Milbemycin Oxime + Spinosad 126
Milbemycin Oxime + Praziquantel 78
Afoxolaner 37
Fluralaner 13.64% 12-Week Chew 36
Fluralaner Chew Tablets 34
Nitenpyram 18
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 16
Lotilaner 14
Ivermectin + Pyrantel 12
Pyrantel Pamoate 11
Carprofen 10
Prednisone 10
Milbemycin Oxime, Lufenuron 9
Milbemycin/Lufenuron/Pzq Chew 9
Outcome Breakdown
Outcome Unknown
251 (44.3%)
Recovered/Normal
141 (24.9%)
Ongoing
116 (20.5%)
Recovered with Sequela
34 (6.0%)
Died
21 (3.7%)
Euthanized
3 (0.5%)
Gender Distribution
Male 319 (56.6%)
Female 232 (41.1%)
Unknown 10 (1.8%)
Mixed 3 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 8 | |
| 2012 | 12 | |
| 2013 | 14 | |
| 2014 | 22 | |
| 2015 | 39 | |
| 2016 | 41 | |
| 2017 | 31 | |
| 2018 | 40 | |
| 2019 | 61 | |
| 2020 | 37 | |
| 2021 | 41 | |
| 2022 | 44 | |
| 2023 | 63 | |
| 2024 | 58 | |
| 2025 | 53 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #131 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.