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Breed profile · FDA CVM July 2026 extract

Siamese adverse-event record

Adverse-event filings for Siamese (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#62 of 510
by report volume (all breeds)
3,073
FDA CVM reports on file
8.1%
death-coded share of reports
#68 of 275
by death-coded share (≥50 reports)

How the 3,073 reports break down

By recorded gender -- every report on file for Siamese, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 322 241.5 161 80.5 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Siamese drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Siamese ranks #62 of 510 by total reports (3,073) and #68 of 275 by death-coded share (8.1%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#62
This breed, reports of 510
#68
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Siamese has 3,073 reports now versus 3,020 in that prior snapshot: 53 more (1.8%).

Report change
+53
Death-coded reports
+3
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Siamese changes

Total Reports

3,073

High report volume

Deaths Reported

250

of 3,073 reports

Death-coded share of reports

8.1%

High death-coded share

Avg Age at Report

7.5 yr

4.8 kg avg weight

Breed Safety Scorecard

F (25/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
8.1%

Share of reports coded as a fatality

Euthanasia rate F
3.5%

Share of reports resulting in euthanasia

Full recovery rate D
28.0%

Share of reports coded "Recovered/Normal"

5-year trend F
+63%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Siamese death-coded reports 8.1%
Cross-breed median

8.1% of 3,073 siamese reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Siamese's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

8% 75th percentile Higher share than 75% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Siamese 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 4.8 kg (10.6 lbs)

Top Reported Reactions

Vomiting 443
Lethargy (see also Central nervous system depression in 'Neurological') 321
Lack of efficacy (ectoparasite) - flea 251
Emesis 226
Anorexia 208
Behavioural disorder NOS 189
Weight loss 179
Lack of efficacy - NOS 172
Application site hair loss 165
Application site alopecia 150
Ataxia 148
Diarrhoea 145
Not eating 138
Hypersalivation 125
Death by euthanasia 119

Most Referenced Drugs

Spinosad 429
Selamectin 375
Fluralaner Spot-On Solution 220
Frunevetmab 207
Cefovecin 191
Nitenpyram 166
Buprenorphine 166
Imidacloprid + Moxidectin 163
Selamectin;Sarolaner 151
Maropitant Citrate 127
Emodepside + Praziquantel 93
Robenacoxib 83
Velagliflozin Proline Monohydrate 83
Bexagliflozin 76
Mirtazapine 70

Outcome Breakdown

Ongoing
901 (30.8%)
Outcome Unknown
883 (30.2%)
Recovered/Normal
860 (29.4%)
Died
141 (4.8%)
Euthanized
109 (3.7%)
Recovered with Sequela
32 (1.1%)

Gender Distribution

Male 1,640 (53.4%)
Female 1,383 (45.0%)
Unknown 32 (1.0%)
Mixed 18 (0.6%)

Reports by Year

Year Reports Trend
2010 90
2011 82
2012 183
2013 225
2014 207
2015 202
2016 176
2017 211
2018 184
2019 180
2020 173
2021 149
2022 166
2023 240
2024 322
2025 243
2026 40

Siamese: high death-coded share in the FDA CVM extract

Signature read: 3,073 reports place Siamese in the upper third of breed filing volume (#62 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Siamese sits at #62 of 510 by report volume among all breeds and #7 of 55 among cat breeds, with 3,073 reports and 250 (8.1%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #68 of 275. Mean age at report: 7.5 years, average weight 4.8 kg (10.6 lbs).

Top reported signs: Vomiting (443), Lethargy (see also Central nervous system depression in 'Neurological') (321), Lack of efficacy (ectoparasite) - flea (251). Most-referenced drug: Spinosad (429 reports), followed by Selamectin (375) and Fluralaner Spot-On Solution (220).

Outcome coding on 2,926 status-recorded reports is dominated by Ongoing (30.8%). Annual submissions ranged 40-2,026 across 17 years on file.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Maine Coon
2,383 reports · 7.6% death-coded
Cat (other)
4,798 reports · 9.7% death-coded
Persian
1,215 reports · 9.7% death-coded
Ragdoll
1,029 reports · 8.7% death-coded
Bengal
673 reports · 4.6% death-coded
Himalayan
640 reports · 10.6% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Siamese drawn from openFDA outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Siamese? ▼
There are 3,073 adverse event reports involving Siamese in the FDA database, of which 250 were death-coded (8.1% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Siamese ranks #62 of 510 by report volume among all breeds PlainBreed indexes (#7 of 55 among cat breeds).
Where does Siamese sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Siamese is #62 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #7 of 55. Among breeds with at least 50 reports, its death-coded share ranks #68 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Siamese? ▼
The most commonly reported adverse reactions for Siamese are Vomiting (443 reports), Lethargy (see also Central nervous system depression in 'Neurological') (321 reports), Lack of efficacy (ectoparasite) - flea (251 reports), Emesis (226 reports), Anorexia (208 reports).
What drugs are most frequently associated with Siamese adverse events? ▼
The drugs most frequently referenced in Siamese adverse event reports are Spinosad (429 reports), Selamectin (375 reports), Fluralaner Spot-On Solution (220 reports), Frunevetmab (207 reports), Cefovecin (191 reports).
What is the average age of Siamese in adverse event reports? ▼
The average age of Siamese at the time of adverse event reports is 7.5 years, with an average weight of 4.8 kg (10.6 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Siamese (Cat), extract as of July 2026 extract. 3,073 reports · 250 death-coded (8.1% of reports, not a mortality rate) · #62 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →