Total Reports
2,946
FDA CVM filings
Cat /
FDA CVM · 2025 release 2,946 reports on file
Siamese - FDA Adverse Event Profile
Adverse-event records for Siamese (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among cat breeds, Siamese is #64 by FDA report volume; 8.3% of its 2,946 reports (244) were death-coded.
- #64
- most-reported cat breed
- 8.3%
- death-coded report share
- 427
- Vomiting - top reaction
- 7.4 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
244
of 2,946 reports
Death Rate
8.3%
death-coded share
Avg Age at Report
7.4 yr
4.7 kg avg weight
Death-Coded Outcome Share
Siamese death-coded reports 8.3%
Cross-breed median
8.3% of 2,946 siamese reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.7 kg (10.4 lbs)
Top Reported Reactions
Vomiting 427
Lethargy (see also Central nervous system depression in 'Neurological') 322
Lack of efficacy (ectoparasite) - flea 231
Emesis 226
Anorexia 203
Behavioural disorder NOS 185
Weight loss 165
Application site hair loss 157
Lack of efficacy - NOS 153
Application site alopecia 150
Ataxia 142
Diarrhoea 133
Not eating 128
Hypersalivation 121
Death 117
Most Referenced Drugs
Spinosad 429
Selamectin 371
Fluralaner Spot-On Solution 203
Frunevetmab 191
Cefovecin 188
Imidacloprid + Moxidectin 163
Nitenpyram 163
Buprenorphine 157
Selamectin;Sarolaner 143
Maropitant Citrate 115
Emodepside + Praziquantel 92
Robenacoxib 80
Mirtazapine 68
Velagliflozin Proline Monohydrate 65
Bexagliflozin 60
Outcome Breakdown
Recovered/Normal
843 (30.1%)
Ongoing
842 (30.1%)
Outcome Unknown
839 (30.0%)
Died
140 (5.0%)
Euthanized
104 (3.7%)
Recovered with Sequela
32 (1.1%)
Gender Distribution
Male 1,577 (53.5%)
Female 1,322 (44.9%)
Unknown 29 (1.0%)
Mixed 18 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 90 | |
| 2011 | 82 | |
| 2012 | 183 | |
| 2013 | 225 | |
| 2014 | 207 | |
| 2015 | 202 | |
| 2016 | 176 | |
| 2017 | 211 | |
| 2018 | 184 | |
| 2019 | 180 | |
| 2020 | 173 | |
| 2021 | 149 | |
| 2022 | 166 | |
| 2023 | 239 | |
| 2024 | 320 | |
| 2025 | 159 | |
Siamese Pet Health Insights
Siamese accounts for 2,946 FDA adverse event reports, ranking #64 by volume among cat breeds, with 244 reports (8.3%) coded as a death outcome. Mean age at report: 7.4 years, average weight 4.7 kg (10.4 lbs).
Top reported signs: Vomiting (427), Lethargy (see also Central nervous system depression in 'Neurological') (322), Lack of efficacy (ectoparasite) - flea (231). Most-referenced drug: Spinosad (429 reports), followed by Selamectin (371) and Fluralaner Spot-On Solution (203).
Outcome coding on 2,800 status-recorded reports is dominated by Recovered/Normal (30.1%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Siamese? ▼
There are 2,946 adverse event reports involving Siamese in the FDA database, with 244 reports involving death (8.3% death rate). Siamese ranks #64 by report volume.
What are the most common adverse reactions reported for Siamese? ▼
The most commonly reported adverse reactions for Siamese are Vomiting (427 reports), Lethargy (see also Central nervous system depression in 'Neurological') (322 reports), Lack of efficacy (ectoparasite) - flea (231 reports), Emesis (226 reports), Anorexia (203 reports).
What drugs are most frequently associated with Siamese adverse events? ▼
The drugs most frequently referenced in Siamese adverse event reports are Spinosad (429 reports), Selamectin (371 reports), Fluralaner Spot-On Solution (203 reports), Frunevetmab (191 reports), Cefovecin (188 reports).
What is the average age of Siamese in adverse event reports? ▼
The average age of Siamese at the time of adverse event reports is 7.4 years, with an average weight of 4.7 kg (10.4 lbs).
Does a high number of adverse event reports mean Siamese is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Siamese safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.