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Breed profile · FDA CVM July 2026 extract

Maine Coon adverse-event record

Adverse-event filings for Maine Coon (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#76 of 510
by report volume (all breeds)
2,383
FDA CVM reports on file
7.6%
death-coded share of reports
#77 of 275
by death-coded share (≥50 reports)

How the 2,383 reports break down

By recorded gender -- every report on file for Maine Coon, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 249 186.75 124.5 62.25 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Maine Coon drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Maine Coon ranks #76 of 510 by total reports (2,383) and #77 of 275 by death-coded share (7.6%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#76
This breed, reports of 510
#77
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Maine Coon has 2,383 reports now versus 2,336 in that prior snapshot: 47 more (2.0%).

Report change
+47
Death-coded reports
+3
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Maine Coon changes

Total Reports

2,383

High report volume

Deaths Reported

181

of 2,383 reports

Death-coded share of reports

7.6%

Above-median death-coded share

Avg Age at Report

7.2 yr

6.1 kg avg weight

Breed Safety Scorecard

F (25/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
7.6%

Share of reports coded as a fatality

Euthanasia rate F
3.1%

Share of reports resulting in euthanasia

Full recovery rate D
27.8%

Share of reports coded "Recovered/Normal"

5-year trend F
+104%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Maine Coon death-coded reports 7.6%
Cross-breed median

7.6% of 2,383 maine coon reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Maine Coon's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

8% 72nd percentile Higher share than 72% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Maine Coon 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 6.1 kg (13.5 lbs)

Top Reported Reactions

Vomiting 308
Lack of efficacy (ectoparasite) - flea 228
Lethargy (see also Central nervous system depression in 'Neurological') 213
Diarrhoea 149
Anorexia 145
Emesis 141
Panting 139
Behavioural disorder NOS 137
Application site hair loss 137
Application site alopecia 121
Lack of efficacy - NOS 121
Weight loss 119
Hyperactivity 103
Vocalisation 98
Not eating 98

Most Referenced Drugs

Spinosad 297
Selamectin 296
Nitenpyram 271
Fluralaner Spot-On Solution 202
Selamectin;Sarolaner 145
Imidacloprid + Moxidectin 139
Frunevetmab 139
Buprenorphine 101
Cefovecin 98
Robenacoxib 71
Maropitant Citrate 70
Velagliflozin Proline Monohydrate 64
Bexagliflozin 57
Fluralaner/Moxidectin Spot-On 52
Emodepside + Praziquantel 46

Outcome Breakdown

Ongoing
706 (31.3%)
Outcome Unknown
687 (30.4%)
Recovered/Normal
663 (29.4%)
Died
106 (4.7%)
Euthanized
75 (3.3%)
Recovered with Sequela
20 (0.9%)

Gender Distribution

Male 1,551 (65.1%)
Female 780 (32.7%)
Unknown 44 (1.8%)
Mixed 8 (0.3%)

Reports by Year

Year Reports Trend
2010 83
2011 65
2012 111
2013 144
2014 161
2015 138
2016 124
2017 164
2018 153
2019 150
2020 128
2021 110
2022 118
2023 222
2024 249
2025 224
2026 39

Maine Coon: high death-coded share in the FDA CVM extract

Signature read: 2,383 reports place Maine Coon in the upper third of breed filing volume (#76 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Maine Coon sits at #76 of 510 by report volume among all breeds and #8 of 55 among cat breeds, with 2,383 reports and 181 (7.6%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #77 of 275. Mean age at report: 7.2 years, average weight 6.1 kg (13.5 lbs).

Top reported signs: Vomiting (308), Lack of efficacy (ectoparasite) - flea (228), Lethargy (see also Central nervous system depression in 'Neurological') (213). Most-referenced drug: Spinosad (297 reports), followed by Selamectin (296) and Nitenpyram (271).

Outcome coding on 2,257 status-recorded reports is dominated by Ongoing (31.3%). Annual submissions ranged 39-2,026 across 17 years on file.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Siamese
3,073 reports · 8.1% death-coded
Persian
1,215 reports · 9.7% death-coded
Ragdoll
1,029 reports · 8.7% death-coded
Bengal
673 reports · 4.6% death-coded
Himalayan
640 reports · 10.6% death-coded
Russian
611 reports · 7.2% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Maine Coon drawn from openFDA outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (7.6% death-coded here).

Shar Pei 7.5% · Dog Terrier - Bedlington 7.7% · Dog Friesian 7.7% · Horse Saint Bernard Dog 7.7% · Dog

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Maine Coon? ▼
There are 2,383 adverse event reports involving Maine Coon in the FDA database, of which 181 were death-coded (7.6% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Maine Coon ranks #76 of 510 by report volume among all breeds PlainBreed indexes (#8 of 55 among cat breeds).
Where does Maine Coon sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Maine Coon is #76 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #8 of 55. Among breeds with at least 50 reports, its death-coded share ranks #77 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Maine Coon? ▼
The most commonly reported adverse reactions for Maine Coon are Vomiting (308 reports), Lack of efficacy (ectoparasite) - flea (228 reports), Lethargy (see also Central nervous system depression in 'Neurological') (213 reports), Diarrhoea (149 reports), Anorexia (145 reports).
What drugs are most frequently associated with Maine Coon adverse events? ▼
The drugs most frequently referenced in Maine Coon adverse event reports are Spinosad (297 reports), Selamectin (296 reports), Nitenpyram (271 reports), Fluralaner Spot-On Solution (202 reports), Selamectin;Sarolaner (145 reports).
What is the average age of Maine Coon in adverse event reports? ▼
The average age of Maine Coon at the time of adverse event reports is 7.2 years, with an average weight of 6.1 kg (13.5 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Maine Coon (Cat), extract as of July 2026 extract. 2,383 reports · 181 death-coded (7.6% of reports, not a mortality rate) · #76 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →