Total Reports
6,057
FDA CVM filings
Cat /
FDA CVM · 2025 release 6,057 reports on file
Domestic Mediumhair - FDA Adverse Event Profile
Adverse-event records for Domestic Mediumhair (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Domestic Mediumhair's FDA record: #35 most-reported cat breed, 6,057 total reports, 7.6% death-coded (460 reports).
- #35
- most-reported cat breed
- 7.6%
- death-coded report share
- 757
- Vomiting - top reaction
- 6.7 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
460
of 6,057 reports
Death Rate
7.6%
death-coded share
Avg Age at Report
6.7 yr
4.8 kg avg weight
Death-Coded Outcome Share
Domestic Mediumhair death-coded reports 7.6%
Cross-breed median
7.6% of 6,057 domestic mediumhair reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.8 kg (10.6 lbs)
Top Reported Reactions
Vomiting 757
Lethargy (see also Central nervous system depression in 'Neurological') 656
Lack of efficacy (ectoparasite) - flea 560
Application site hair loss 451
Emesis 378
Behavioural disorder NOS 350
Application site alopecia 327
Weight loss 316
Anorexia 301
Diarrhoea 290
Ataxia 263
Lack of efficacy - NOS 261
Lethargy (see also Central nervous system depression in Neurological) 259
Not eating 255
Hyperactivity 222
Most Referenced Drugs
Spinosad 786
Fluralaner Spot-On Solution 663
Selamectin 635
Nitenpyram 470
Selamectin;Sarolaner 402
Imidacloprid + Moxidectin 385
Frunevetmab 354
Emodepside + Praziquantel 301
Cefovecin 285
Buprenorphine 276
Maropitant Citrate 205
Fluralaner/Moxidectin Spot-On 194
Velagliflozin Proline Monohydrate 194
Bexagliflozin 166
Robenacoxib 165
Outcome Breakdown
Ongoing
1,965 (32.4%)
Recovered/Normal
1,808 (29.8%)
Outcome Unknown
1,792 (29.5%)
Died
250 (4.1%)
Euthanized
210 (3.5%)
Recovered with Sequela
40 (0.7%)
Gender Distribution
Male 3,065 (50.6%)
Female 2,895 (47.8%)
Unknown 65 (1.1%)
Mixed 32 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 8 | |
| 2011 | 52 | |
| 2012 | 228 | |
| 2013 | 373 | |
| 2014 | 341 | |
| 2015 | 351 | |
| 2016 | 374 | |
| 2017 | 437 | |
| 2018 | 472 | |
| 2019 | 449 | |
| 2020 | 403 | |
| 2021 | 360 | |
| 2022 | 378 | |
| 2023 | 589 | |
| 2024 | 809 | |
| 2025 | 433 | |
Domestic Mediumhair Pet Health Insights
Domestic Mediumhair accounts for 6,057 FDA adverse event reports, ranking #35 by volume among cat breeds, with 460 reports (7.6%) coded as a death outcome. Mean age at report: 6.7 years, average weight 4.8 kg (10.6 lbs).
Top reported signs: Vomiting (757), Lethargy (see also Central nervous system depression in 'Neurological') (656), Lack of efficacy (ectoparasite) - flea (560). Most-referenced drug: Spinosad (786 reports), followed by Fluralaner Spot-On Solution (663) and Selamectin (635).
Outcome coding on 6,065 status-recorded reports is dominated by Ongoing (32.4%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Domestic Mediumhair? ▼
There are 6,057 adverse event reports involving Domestic Mediumhair in the FDA database, with 460 reports involving death (7.6% death rate). Domestic Mediumhair ranks #35 by report volume.
What are the most common adverse reactions reported for Domestic Mediumhair? ▼
The most commonly reported adverse reactions for Domestic Mediumhair are Vomiting (757 reports), Lethargy (see also Central nervous system depression in 'Neurological') (656 reports), Lack of efficacy (ectoparasite) - flea (560 reports), Application site hair loss (451 reports), Emesis (378 reports).
What drugs are most frequently associated with Domestic Mediumhair adverse events? ▼
The drugs most frequently referenced in Domestic Mediumhair adverse event reports are Spinosad (786 reports), Fluralaner Spot-On Solution (663 reports), Selamectin (635 reports), Nitenpyram (470 reports), Selamectin;Sarolaner (402 reports).
What is the average age of Domestic Mediumhair in adverse event reports? ▼
The average age of Domestic Mediumhair at the time of adverse event reports is 6.7 years, with an average weight of 4.8 kg (10.6 lbs).
Does a high number of adverse event reports mean Domestic Mediumhair is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Domestic Mediumhair safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.