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Breed profile · FDA CVM July 2026 extract

Domestic Mediumhair adverse-event record

Adverse-event filings for Domestic Mediumhair (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#35 of 510
by report volume (all breeds)
6,441
FDA CVM reports on file
7.7%
death-coded share of reports
#73 of 275
by death-coded share (≥50 reports)

How the 6,441 reports break down

By recorded gender -- every report on file for Domestic Mediumhair, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 815 611.25 407.5 203.75 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Domestic Mediumhair drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Domestic Mediumhair ranks #35 of 510 by total reports (6,441) and #73 of 275 by death-coded share (7.7%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#35
This breed, reports of 510
#73
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Domestic Mediumhair has 6,441 reports now versus 6,299 in that prior snapshot: 142 more (2.3%).

Report change
+142
Death-coded reports
+11
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Domestic Mediumhair changes

Total Reports

6,441

Highest-reported breed

Deaths Reported

499

of 6,441 reports

Death-coded share of reports

7.7%

Above-median death-coded share

Avg Age at Report

6.8 yr

4.8 kg avg weight

Breed Safety Scorecard

F (25/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
7.7%

Share of reports coded as a fatality

Euthanasia rate F
3.6%

Share of reports resulting in euthanasia

Full recovery rate C-
29.0%

Share of reports coded "Recovered/Normal"

5-year trend F
+96%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Domestic Mediumhair death-coded reports 7.7%
Cross-breed median

7.7% of 6,441 domestic mediumhair reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Domestic Mediumhair's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

8% 73rd percentile Higher share than 73% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Domestic Mediumhair 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Domestic Mediumhair among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Domestic Mediumhair vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 4.8 kg (10.6 lbs)

Top Reported Reactions

Vomiting 802
Lethargy (see also Central nervous system depression in 'Neurological') 656
Lack of efficacy (ectoparasite) - flea 613
Application site hair loss 468
Emesis 382
Behavioural disorder NOS 369
Weight loss 362
Application site alopecia 333
Anorexia 318
Diarrhoea 314
Lethargy (see also Central nervous system depression in Neurological) 311
Lack of efficacy - NOS 295
Not eating 278
Ataxia 271
Death 234

Most Referenced Drugs

Spinosad 787
Fluralaner Spot-On Solution 701
Selamectin 645
Nitenpyram 483
Selamectin;Sarolaner 435
Frunevetmab 414
Imidacloprid + Moxidectin 386
Buprenorphine 309
Emodepside + Praziquantel 306
Cefovecin 304
Velagliflozin Proline Monohydrate 245
Maropitant Citrate 235
Fluralaner/Moxidectin Spot-On 215
Bexagliflozin 199
Robenacoxib 189

Outcome Breakdown

Ongoing
2,130 (33.0%)
Outcome Unknown
1,912 (29.6%)
Recovered/Normal
1,867 (29.0%)
Died
267 (4.1%)
Euthanized
232 (3.6%)
Recovered with Sequela
41 (0.6%)

Gender Distribution

Male 3,265 (50.7%)
Female 3,071 (47.7%)
Unknown 70 (1.1%)
Mixed 35 (0.5%)

Reports by Year

Year Reports Trend
2010 8
2011 52
2012 228
2013 373
2014 341
2015 351
2016 374
2017 437
2018 472
2019 449
2020 403
2021 360
2022 380
2023 590
2024 815
2025 706
2026 102

Domestic Mediumhair: high death-coded share in the FDA CVM extract

Signature read: 6,441 reports place Domestic Mediumhair in the upper third of breed filing volume (#35 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Domestic Mediumhair sits at #35 of 510 by report volume among all breeds and #5 of 55 among cat breeds, with 6,441 reports and 499 (7.7%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #73 of 275. Mean age at report: 6.8 years, average weight 4.8 kg (10.6 lbs).

Top reported signs: Vomiting (802), Lethargy (see also Central nervous system depression in 'Neurological') (656), Lack of efficacy (ectoparasite) - flea (613). Most-referenced drug: Spinosad (787 reports), followed by Fluralaner Spot-On Solution (701) and Selamectin (645).

Outcome coding on 6,449 status-recorded reports is dominated by Ongoing (33.0%). Annual submissions ranged 8-2,026 across 17 years on file.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Domestic (unspecified)
7,576 reports · 13.4% death-coded
Cat (other)
4,798 reports · 9.7% death-coded
Domestic Longhair
9,615 reports · 7.0% death-coded
Siamese
3,073 reports · 8.1% death-coded
Maine Coon
2,383 reports · 7.6% death-coded
Persian
1,215 reports · 9.7% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Domestic Mediumhair drawn from openFDA outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (7.7% death-coded here).

Saint Bernard Dog 7.7% · Dog Terrier - Bedlington 7.7% · Dog Friesian 7.7% · Horse Pointing Dog - Italian Wire-haired 7.8% · Dog

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Domestic Mediumhair? ▼
There are 6,441 adverse event reports involving Domestic Mediumhair in the FDA database, of which 499 were death-coded (7.7% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Domestic Mediumhair ranks #35 of 510 by report volume among all breeds PlainBreed indexes (#5 of 55 among cat breeds).
Where does Domestic Mediumhair sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Domestic Mediumhair is #35 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #5 of 55. Among breeds with at least 50 reports, its death-coded share ranks #73 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Domestic Mediumhair? ▼
The most commonly reported adverse reactions for Domestic Mediumhair are Vomiting (802 reports), Lethargy (see also Central nervous system depression in 'Neurological') (656 reports), Lack of efficacy (ectoparasite) - flea (613 reports), Application site hair loss (468 reports), Emesis (382 reports).
What drugs are most frequently associated with Domestic Mediumhair adverse events? ▼
The drugs most frequently referenced in Domestic Mediumhair adverse event reports are Spinosad (787 reports), Fluralaner Spot-On Solution (701 reports), Selamectin (645 reports), Nitenpyram (483 reports), Selamectin;Sarolaner (435 reports).
What is the average age of Domestic Mediumhair in adverse event reports? ▼
The average age of Domestic Mediumhair at the time of adverse event reports is 6.8 years, with an average weight of 4.8 kg (10.6 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Domestic Mediumhair (Cat), extract as of July 2026 extract. 6,441 reports · 499 death-coded (7.7% of reports, not a mortality rate) · #35 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →