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Breed profile · FDA CVM July 2026 extract

Domestic (unspecified) adverse-event record

Adverse-event filings for Domestic (unspecified) (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#28 of 510
by report volume (all breeds)
7,576
FDA CVM reports on file
13.4%
death-coded share of reports
#33 of 275
by death-coded share (≥50 reports)

How the 7,576 reports break down

By recorded gender -- every report on file for Domestic (unspecified), no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 57 42.75 28.5 14.25 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Domestic (unspecified) drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Domestic (unspecified) ranks #28 of 510 by total reports (7,576) and #33 of 275 by death-coded share (13.4%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#28
This breed, reports of 510
#33
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Domestic (unspecified) has 7,576 reports now versus 7,570 in that prior snapshot: 6 more (0.1%).

Report change
+6
Death-coded reports
+1
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Domestic (unspecified) changes

Total Reports

7,576

Highest-reported breed

Deaths Reported

1,014

of 7,576 reports

Death-coded share of reports

13.4%

High death-coded share

Avg Age at Report

6.5 yr

4.8 kg avg weight

Breed Safety Scorecard

F (31/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
13.4%

Share of reports coded as a fatality

Euthanasia rate A+
0.2%

Share of reports resulting in euthanasia

Full recovery rate F
4.1%

Share of reports coded "Recovered/Normal"

5-year trend C-
+7%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Domestic (unspecified) death-coded reports 13.4%
Cross-breed median

13.4% of 7,576 domestic (unspecified) reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Domestic (unspecified)'s death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

13% 88th percentile Higher share than 88% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). Below this entry. 20%–25%: 2 indexed breeds (1%). Below this entry. 25%–30%: 3 indexed breeds (1%). Below this entry. 30%–35%: 4 indexed breeds (1%). Below this entry. 35%–40%: 5 indexed breeds (2%). Below this entry. 40%–45%: 6 indexed breeds (2%). Below this entry. 45%–50%: 3 indexed breeds (1%). Below this entry. 50%–55%: 7 indexed breeds (3%). Below this entry. 55%–60%: 7 indexed breeds (3%). Below this entry. 60%–65%: 21 indexed breeds (8%). Below this entry. 65%–70%: 11 indexed breeds (4%). Below this entry. 70%–75%: 15 indexed breeds (5%). Below this entry. 75%–80%: 13 indexed breeds (5%). Below this entry. 80%–85%: 11 indexed breeds (4%). Below this entry. 85%–90%: 12 indexed breeds (4%). Below this entry. 90%–95%: 12 indexed breeds (4%). Below this entry. 95%–100%: 142 indexed breeds (52%). This entry sits in this band. Domestic (unspecified) 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Domestic (unspecified) among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Domestic (unspecified) vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 4.8 kg (10.6 lbs)

Top Reported Reactions

Depression 1,233
Vomiting 1,205
Anorexia 1,150
Application site alopecia 943
Death 561
Hypersalivation 516
Ataxia 460
Death by euthanasia 437
Diarrhoea 372
Elevated blood urea nitrogen (BUN) 359
Fever 320
Lack of efficacy (ectoparasite) - flea 307
Application site lesion 307
Elevated creatinine 305
Weight loss 289

Most Referenced Drugs

Selamectin 1,991
Cefovecin Sodium 752
Spinosad 483
Human Insulin 453
Nitenpyram 448
Meloxicam 442
Imidacloprid, Moxidectin 390
Emodepside, Praziquantel 263
Cyclosporine 229
Ketamine Hydrochloride 190
Dexmedetomidine Hydrochloride 158
Amoxicillin, Clavulanate 136
Orbifloxacin 133
Maropitant 127
Methylprednisolone Acetate 105

Outcome Breakdown

Died
1,000 (58.6%)
Recovered/Normal
312 (18.3%)
Outcome Unknown
271 (15.9%)
Ongoing
97 (5.7%)
Euthanized
14 (0.8%)
Recovered with Sequela
12 (0.7%)

Gender Distribution

Male 3,890 (51.3%)
Female 3,349 (44.2%)
Unknown 186 (2.5%)
Mixed 151 (2.0%)

Reports by Year

Year Reports Trend
2010 3,309
2011 2,343
2012 1,083
2013 178
2014 127
2015 81
2016 53
2017 43
2018 39
2019 32
2020 45
2021 46
2022 49
2023 36
2024 57
2025 49
2026 6

Domestic (unspecified): high death-coded share in the FDA CVM extract

Signature read: 7,576 reports place Domestic (unspecified) in the upper third of breed filing volume (#28 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Domestic (unspecified) sits at #28 of 510 by report volume among all breeds and #4 of 55 among cat breeds, with 7,576 reports and 1,014 (13.4%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #33 of 275. Mean age at report: 6.5 years, average weight 4.8 kg (10.6 lbs).

Top reported signs: Depression (1,233), Vomiting (1,205), Anorexia (1,150). Most-referenced drug: Selamectin (1,991 reports), followed by Cefovecin Sodium (752) and Spinosad (483).

Outcome coding on 1,706 status-recorded reports is dominated by Died (58.6%). Annual submissions ranged 6-2,026 across 17 years on file.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Domestic Mediumhair
6,441 reports · 7.7% death-coded
Domestic Longhair
9,615 reports · 7.0% death-coded
Cat (other)
4,798 reports · 9.7% death-coded
Siamese
3,073 reports · 8.1% death-coded
Maine Coon
2,383 reports · 7.6% death-coded
Cat (unknown)
13,248 reports · 9.3% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Domestic (unspecified) drawn from openFDA outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (13.4% death-coded here).

Paint 13.7% · Horse Tennessee Walking Horse 12.9% · Horse Pony (unspecified) 11.9% · Horse Standardbred (unspecified) 14.9% · Horse

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Domestic (unspecified)? ▼
There are 7,576 adverse event reports involving Domestic (unspecified) in the FDA database, of which 1,014 were death-coded (13.4% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Domestic (unspecified) ranks #28 of 510 by report volume among all breeds PlainBreed indexes (#4 of 55 among cat breeds).
Where does Domestic (unspecified) sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Domestic (unspecified) is #28 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #4 of 55. Among breeds with at least 50 reports, its death-coded share ranks #33 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Domestic (unspecified)? ▼
The most commonly reported adverse reactions for Domestic (unspecified) are Depression (1,233 reports), Vomiting (1,205 reports), Anorexia (1,150 reports), Application site alopecia (943 reports), Death (561 reports).
What drugs are most frequently associated with Domestic (unspecified) adverse events? ▼
The drugs most frequently referenced in Domestic (unspecified) adverse event reports are Selamectin (1,991 reports), Cefovecin Sodium (752 reports), Spinosad (483 reports), Human Insulin (453 reports), Nitenpyram (448 reports).
What is the average age of Domestic (unspecified) in adverse event reports? ▼
The average age of Domestic (unspecified) at the time of adverse event reports is 6.5 years, with an average weight of 4.8 kg (10.6 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Domestic (unspecified) (Cat), extract as of July 2026 extract. 7,576 reports · 1,014 death-coded (13.4% of reports, not a mortality rate) · #28 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →