Total Reports
7,559
FDA CVM filings
Cat /
FDA CVM · 2025 release 7,559 reports on file
Domestic (unspecified) - FDA Adverse Event Profile
Adverse-event records for Domestic (unspecified) (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 7,559 reports on file, Domestic (unspecified) sits at #25 among cat breeds by volume; death-coded share is 13.4% (1,012 reports).
- #25
- most-reported cat breed
- 13.4%
- death-coded report share
- 1,233
- Depression - top reaction
- 6.5 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
1,012
of 7,559 reports
Death Rate
13.4%
death-coded share
Avg Age at Report
6.5 yr
4.8 kg avg weight
Death-Coded Outcome Share
Domestic (unspecified) death-coded reports 13.4%
Cross-breed median
13.4% of 7,559 domestic (unspecified) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.8 kg (10.6 lbs)
Top Reported Reactions
Depression 1,233
Vomiting 1,202
Anorexia 1,149
Application site alopecia 942
Death 561
Hypersalivation 516
Ataxia 460
Death by euthanasia 436
Diarrhoea 372
Elevated blood urea nitrogen (BUN) 359
Fever 318
Application site lesion 307
Lack of efficacy (ectoparasite) - flea 307
Elevated creatinine 305
Weight loss 289
Most Referenced Drugs
Selamectin 1,991
Cefovecin Sodium 752
Spinosad 483
Human Insulin 453
Nitenpyram 446
Meloxicam 442
Imidacloprid, Moxidectin 390
Emodepside, Praziquantel 263
Cyclosporine 229
Ketamine Hydrochloride 190
Dexmedetomidine Hydrochloride 157
Amoxicillin, Clavulanate 136
Orbifloxacin 133
Maropitant 127
Methylprednisolone Acetate 105
Outcome Breakdown
Died
999 (59.1%)
Recovered/Normal
308 (18.2%)
Outcome Unknown
264 (15.6%)
Ongoing
93 (5.5%)
Euthanized
13 (0.8%)
Recovered with Sequela
12 (0.7%)
Gender Distribution
Male 3,885 (51.4%)
Female 3,338 (44.2%)
Unknown 186 (2.5%)
Mixed 150 (2.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3,309 | |
| 2011 | 2,343 | |
| 2012 | 1,083 | |
| 2013 | 178 | |
| 2014 | 127 | |
| 2015 | 81 | |
| 2016 | 53 | |
| 2017 | 43 | |
| 2018 | 39 | |
| 2019 | 32 | |
| 2020 | 45 | |
| 2021 | 46 | |
| 2022 | 49 | |
| 2023 | 36 | |
| 2024 | 57 | |
| 2025 | 38 | |
Domestic (unspecified) Pet Health Insights
Domestic (unspecified) accounts for 7,559 FDA adverse event reports, ranking #25 by volume among cat breeds, with 1,012 reports (13.4%) coded as a death outcome. Mean age at report: 6.5 years, average weight 4.8 kg (10.6 lbs).
Top reported signs: Depression (1,233), Vomiting (1,202), Anorexia (1,149). Most-referenced drug: Selamectin (1,991 reports), followed by Cefovecin Sodium (752) and Spinosad (483).
Outcome coding on 1,689 status-recorded reports is dominated by Died (59.1%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Domestic (unspecified)? ▼
There are 7,559 adverse event reports involving Domestic (unspecified) in the FDA database, with 1,012 reports involving death (13.4% death rate). Domestic (unspecified) ranks #25 by report volume.
What are the most common adverse reactions reported for Domestic (unspecified)? ▼
The most commonly reported adverse reactions for Domestic (unspecified) are Depression (1,233 reports), Vomiting (1,202 reports), Anorexia (1,149 reports), Application site alopecia (942 reports), Death (561 reports).
What drugs are most frequently associated with Domestic (unspecified) adverse events? ▼
The drugs most frequently referenced in Domestic (unspecified) adverse event reports are Selamectin (1,991 reports), Cefovecin Sodium (752 reports), Spinosad (483 reports), Human Insulin (453 reports), Nitenpyram (446 reports).
What is the average age of Domestic (unspecified) in adverse event reports? ▼
The average age of Domestic (unspecified) at the time of adverse event reports is 6.5 years, with an average weight of 4.8 kg (10.6 lbs).
Does a high number of adverse event reports mean Domestic (unspecified) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Domestic (unspecified) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.