Total Reports
9,078
FDA CVM filings
Cat /
FDA CVM · 2025 release 9,078 reports on file
Domestic Longhair - FDA Adverse Event Profile
Adverse-event records for Domestic Longhair (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Domestic Longhair's FDA record: #21 most-reported cat breed, 9,078 total reports, 6.9% death-coded (630 reports).
- #21
- most-reported cat breed
- 6.9%
- death-coded report share
- 1,102
- Vomiting - top reaction
- 7.5 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
630
of 9,078 reports
Death Rate
6.9%
death-coded share
Avg Age at Report
7.5 yr
4.9 kg avg weight
Death-Coded Outcome Share
Domestic Longhair death-coded reports 6.9%
Cross-breed median
6.9% of 9,078 domestic longhair reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.9 kg (10.8 lbs)
Top Reported Reactions
Vomiting 1,102
Lethargy (see also Central nervous system depression in 'Neurological') 963
Lack of efficacy (ectoparasite) - flea 941
Emesis 569
Behavioural disorder NOS 542
Lack of efficacy - NOS 523
Anorexia 510
Application site hair loss 503
Panting 489
Weight loss 488
Diarrhoea 456
Vocalisation 405
Hyperactivity 401
Not eating 377
Application site alopecia 349
Most Referenced Drugs
Spinosad 1,226
Nitenpyram 1,020
Fluralaner Spot-On Solution 911
Selamectin 846
Frunevetmab 617
Imidacloprid + Moxidectin 596
Cefovecin 464
Selamectin;Sarolaner 454
Buprenorphine 377
Emodepside + Praziquantel 322
Velagliflozin Proline Monohydrate 275
Bexagliflozin 258
Fluralaner/Moxidectin Spot-On 230
Maropitant Citrate 220
Robenacoxib 203
Outcome Breakdown
Outcome Unknown
2,888 (31.8%)
Ongoing
2,874 (31.6%)
Recovered/Normal
2,648 (29.1%)
Died
361 (4.0%)
Euthanized
269 (3.0%)
Recovered with Sequela
46 (0.5%)
Gender Distribution
Male 4,643 (51.1%)
Female 4,289 (47.2%)
Unknown 94 (1.0%)
Mixed 52 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 19 | |
| 2011 | 105 | |
| 2012 | 368 | |
| 2013 | 627 | |
| 2014 | 592 | |
| 2015 | 600 | |
| 2016 | 622 | |
| 2017 | 747 | |
| 2018 | 664 | |
| 2019 | 608 | |
| 2020 | 559 | |
| 2021 | 443 | |
| 2022 | 506 | |
| 2023 | 938 | |
| 2024 | 1,118 | |
| 2025 | 562 | |
Domestic Longhair Pet Health Insights
Domestic Longhair accounts for 9,078 FDA adverse event reports, ranking #21 by volume among cat breeds, with 630 reports (6.9%) coded as a death outcome. Mean age at report: 7.5 years, average weight 4.9 kg (10.8 lbs).
Top reported signs: Vomiting (1,102), Lethargy (see also Central nervous system depression in 'Neurological') (963), Lack of efficacy (ectoparasite) - flea (941). Most-referenced drug: Spinosad (1,226 reports), followed by Nitenpyram (1,020) and Fluralaner Spot-On Solution (911).
Outcome coding on 9,086 status-recorded reports is dominated by Outcome Unknown (31.8%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Domestic Longhair? ▼
There are 9,078 adverse event reports involving Domestic Longhair in the FDA database, with 630 reports involving death (6.9% death rate). Domestic Longhair ranks #21 by report volume.
What are the most common adverse reactions reported for Domestic Longhair? ▼
The most commonly reported adverse reactions for Domestic Longhair are Vomiting (1,102 reports), Lethargy (see also Central nervous system depression in 'Neurological') (963 reports), Lack of efficacy (ectoparasite) - flea (941 reports), Emesis (569 reports), Behavioural disorder NOS (542 reports).
What drugs are most frequently associated with Domestic Longhair adverse events? ▼
The drugs most frequently referenced in Domestic Longhair adverse event reports are Spinosad (1,226 reports), Nitenpyram (1,020 reports), Fluralaner Spot-On Solution (911 reports), Selamectin (846 reports), Frunevetmab (617 reports).
What is the average age of Domestic Longhair in adverse event reports? ▼
The average age of Domestic Longhair at the time of adverse event reports is 7.5 years, with an average weight of 4.9 kg (10.8 lbs).
Does a high number of adverse event reports mean Domestic Longhair is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Domestic Longhair safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.