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Breed profile · FDA CVM July 2026 extract

Cat (unknown) adverse-event record

Adverse-event filings for Cat (unknown) (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#17 of 510
by report volume (all breeds)
13,248
FDA CVM reports on file
9.3%
death-coded share of reports
#56 of 275
by death-coded share (≥50 reports)

How the 13,248 reports break down

By recorded gender -- every report on file for Cat (unknown), no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 1,594 1,195.5 797 398.5 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Cat (unknown) drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Cat (unknown) ranks #17 of 510 by total reports (13,248) and #56 of 275 by death-coded share (9.3%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#17
This breed, reports of 510
#56
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cat (unknown) has 13,248 reports now versus 12,993 in that prior snapshot: 255 more (2.0%).

Report change
+255
Death-coded reports
+19
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cat (unknown) changes

Total Reports

13,248

Highest-reported breed

Deaths Reported

1,235

of 13,248 reports

Death-coded share of reports

9.3%

High death-coded share

Avg Age at Report

6.8 yr

4.6 kg avg weight

Breed Safety Scorecard

F (21/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
9.3%

Share of reports coded as a fatality

Euthanasia rate F
2.6%

Share of reports resulting in euthanasia

Full recovery rate F
20.3%

Share of reports coded "Recovered/Normal"

5-year trend F
+64%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Cat (unknown) death-coded reports 9.3%
Cross-breed median

9.3% of 13,248 cat (unknown) reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Cat (unknown)'s death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

9% 80th percentile Higher share than 80% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Cat (unknown) 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Cat (unknown) among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Cat (unknown) vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 4.6 kg (10.1 lbs)

Top Reported Reactions

Lack of efficacy (ectoparasite) - flea 2,038
Vomiting 1,150
Lack of efficacy - NOS 1,071
Death 798
Behavioural disorder NOS 729
Lethargy (see also Central nervous system depression in 'Neurological') 535
Hypersalivation 478
Anorexia 458
Diarrhoea 436
Hyperactivity 375
Emesis 372
Application site alopecia 353
Death by euthanasia 347
Weight loss 327
Not eating 306

Most Referenced Drugs

Nitenpyram 1,180
Buprenorphine 1,092
Spinosad 1,079
Selamectin 1,012
Fluralaner Spot-On Solution 950
Imidacloprid + Moxidectin 940
Bexagliflozin 590
Emodepside + Praziquantel 511
Praziquantel 472
Robenacoxib 443
Eprinomectin + Esafoxolaner + Praziquantel 399
Velagliflozin Proline Monohydrate 318
Cyclosporine 289
Fluralaner/Moxidectin Spot-On 237
Mirtazapine 220

Outcome Breakdown

Outcome Unknown
6,591 (52.6%)
Recovered/Normal
2,685 (21.4%)
Ongoing
1,955 (15.6%)
Died
902 (7.2%)
Euthanized
338 (2.7%)
Recovered with Sequela
50 (0.4%)

Gender Distribution

Unknown 7,863 (59.4%)
Male 2,672 (20.2%)
Female 2,529 (19.1%)
Mixed 184 (1.4%)

Reports by Year

Year Reports Trend
2010 464
2011 392
2012 770
2013 771
2014 690
2015 624
2016 542
2017 653
2018 647
2019 669
2020 753
2021 810
2022 929
2023 1,436
2024 1,594
2025 1,327
2026 177

Cat (unknown): high death-coded share in the FDA CVM extract

Signature read: 13,248 reports place Cat (unknown) in the upper third of breed filing volume (#17 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Cat (unknown) sits at #17 of 510 by report volume among all breeds and #2 of 55 among cat breeds, with 13,248 reports and 1,235 (9.3%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #56 of 275. Mean age at report: 6.8 years, average weight 4.6 kg (10.1 lbs).

Top reported signs: Lack of efficacy (ectoparasite) - flea (2,038), Vomiting (1,150), Lack of efficacy - NOS (1,071). Most-referenced drug: Nitenpyram (1,180 reports), followed by Buprenorphine (1,092) and Spinosad (1,079).

Outcome coding on 12,521 status-recorded reports is dominated by Outcome Unknown (52.6%). Annual submissions ranged 177-2,026 across 17 years on file.

Cat (unknown) Reporting Concentration Profile

Cat (unknown) is a high-volume FDA CVM cohort (13,248 reports) - enough filings to measure how concentrated the reaction and drug mix is, not just the headline totals. Across 20 named reaction terms in the stored top list, the leading three (Lack of efficacy (ectoparasite) - flea, Vomiting, Lack of efficacy - NOS) account for 38.5% of listed reaction mentions. The Herfindahl index on that list is 0.080 (1.0 = a single reaction owns every mention; lower = a broader clinical mix).

On the drug side, 20 referenced products appear in the top list; the leading three (Nitenpyram, Buprenorphine, Spinosad) cover 31.5% of those mentions. That multi-product footprint is the profile thin-report breeds cannot show - their pages stop at a short bar list because the sample cannot support a concentration read.

Outcome coding on 12,521 status-recorded filings splits roughly 9.9% severe (died or euthanized - 1,240 reports) versus 21.8% recovered or recovered-with-sequela (2,735). Read that split next to the 9.3% death-coded share above - both track reporting severity bias in a popular breed, not a proven mortality rate.

Peak filing year was 2024 (1,594 reports); the lightest year on file was 2026 (177). From 2024 to 2025, annual volume fell 16.8% (1,594 → 1,327). Year-to-year swings at this volume usually track product launches, owner awareness, and reporting campaigns more than sudden breed-health shocks.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Domestic Longhair
9,615 reports · 7.0% death-coded
Domestic (unspecified)
7,576 reports · 13.4% death-coded
Domestic Mediumhair
6,441 reports · 7.7% death-coded
Cat (other)
4,798 reports · 9.7% death-coded
Siamese
3,073 reports · 8.1% death-coded
Maine Coon
2,383 reports · 7.6% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Cat (unknown) drawn from openFDA outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (9.3% death-coded here).

Bulldog - English 9.1% · Dog Arab 9.6% · Horse Pointer - English Pointer 9.0% · Dog Horse (other) 9.8% · Horse

Similar average weight

Nearest other-species breeds by reported average weight (4.6 kg here).

Poodle - Toy 4.5 kg · Dog Chihuahua 4.8 kg · Dog New Zealand White 4.3 kg · Rabbit Maltese 4.9 kg · Dog

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Cat (unknown)? ▼
There are 13,248 adverse event reports involving Cat (unknown) in the FDA database, of which 1,235 were death-coded (9.3% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Cat (unknown) ranks #17 of 510 by report volume among all breeds PlainBreed indexes (#2 of 55 among cat breeds).
Where does Cat (unknown) sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Cat (unknown) is #17 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #2 of 55. Among breeds with at least 50 reports, its death-coded share ranks #56 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Cat (unknown)? ▼
The most commonly reported adverse reactions for Cat (unknown) are Lack of efficacy (ectoparasite) - flea (2,038 reports), Vomiting (1,150 reports), Lack of efficacy - NOS (1,071 reports), Death (798 reports), Behavioural disorder NOS (729 reports).
What drugs are most frequently associated with Cat (unknown) adverse events? ▼
The drugs most frequently referenced in Cat (unknown) adverse event reports are Nitenpyram (1,180 reports), Buprenorphine (1,092 reports), Spinosad (1,079 reports), Selamectin (1,012 reports), Fluralaner Spot-On Solution (950 reports).
What is the average age of Cat (unknown) in adverse event reports? ▼
The average age of Cat (unknown) at the time of adverse event reports is 6.8 years, with an average weight of 4.6 kg (10.1 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cat (unknown) (Cat), extract as of July 2026 extract. 13,248 reports · 1,235 death-coded (9.3% of reports, not a mortality rate) · #17 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →