Total Reports
61,410
FDA CVM filings
Cat /
FDA CVM · 2025 release 61,410 reports on file
Domestic Shorthair - FDA Adverse Event Profile
Adverse-event records for Domestic Shorthair (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 61,410 reports on file, Domestic Shorthair sits at #3 among cat breeds by volume; death-coded share is 7.2% (4,445 reports).
- #3
- most-reported cat breed
- 7.2%
- death-coded report share
- 7,669
- Vomiting - top reaction
- 7.0 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
4,445
of 61,410 reports
Death Rate
7.2%
death-coded share
Avg Age at Report
7.0 yr
4.9 kg avg weight
Death-Coded Outcome Share
Domestic Shorthair death-coded reports 7.2%
Cross-breed median
7.2% of 61,410 domestic shorthair reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.9 kg (10.8 lbs)
Top Reported Reactions
Vomiting 7,669
Lethargy (see also Central nervous system depression in 'Neurological') 5,954
Application site hair loss 5,129
Lack of efficacy (ectoparasite) - flea 4,360
Application site alopecia 3,571
Emesis 3,444
Anorexia 3,356
Lack of efficacy - NOS 3,298
Behavioural disorder NOS 3,243
Weight loss 3,070
Diarrhoea 2,876
Hypersalivation 2,587
Ataxia 2,457
Not eating 2,420
Lethargy (see also Central nervous system depression in Neurological) 2,294
Most Referenced Drugs
Selamectin 6,642
Spinosad 6,477
Fluralaner Spot-On Solution 5,905
Selamectin;Sarolaner 4,234
Frunevetmab 4,102
Imidacloprid + Moxidectin 3,794
Nitenpyram 3,383
Cefovecin 3,307
Emodepside + Praziquantel 3,145
Buprenorphine 2,770
Velagliflozin Proline Monohydrate 2,165
Bexagliflozin 2,017
Fluralaner/Moxidectin Spot-On 1,812
Maropitant Citrate 1,788
Robenacoxib 1,691
Outcome Breakdown
Ongoing
20,573 (33.5%)
Outcome Unknown
18,504 (30.1%)
Recovered/Normal
17,552 (28.6%)
Died
2,314 (3.8%)
Euthanized
2,133 (3.5%)
Recovered with Sequela
399 (0.6%)
Gender Distribution
Male 32,361 (52.7%)
Female 27,822 (45.3%)
Unknown 831 (1.4%)
Mixed 396 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 134 | |
| 2011 | 828 | |
| 2012 | 2,573 | |
| 2013 | 3,930 | |
| 2014 | 3,457 | |
| 2015 | 3,519 | |
| 2016 | 3,740 | |
| 2017 | 4,465 | |
| 2018 | 4,195 | |
| 2019 | 4,256 | |
| 2020 | 3,742 | |
| 2021 | 3,405 | |
| 2022 | 3,698 | |
| 2023 | 6,440 | |
| 2024 | 8,383 | |
| 2025 | 4,645 | |
Domestic Shorthair Pet Health Insights
Domestic Shorthair accounts for 61,410 FDA adverse event reports, ranking #3 by volume among cat breeds, with 4,445 reports (7.2%) coded as a death outcome. Mean age at report: 7.0 years, average weight 4.9 kg (10.8 lbs).
Top reported signs: Vomiting (7,669), Lethargy (see also Central nervous system depression in 'Neurological') (5,954), Application site hair loss (5,129). Most-referenced drug: Selamectin (6,642 reports), followed by Spinosad (6,477) and Fluralaner Spot-On Solution (5,905).
Outcome coding on 61,475 status-recorded reports is dominated by Ongoing (33.5%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Domestic Shorthair? ▼
There are 61,410 adverse event reports involving Domestic Shorthair in the FDA database, with 4,445 reports involving death (7.2% death rate). Domestic Shorthair ranks #3 by report volume.
What are the most common adverse reactions reported for Domestic Shorthair? ▼
The most commonly reported adverse reactions for Domestic Shorthair are Vomiting (7,669 reports), Lethargy (see also Central nervous system depression in 'Neurological') (5,954 reports), Application site hair loss (5,129 reports), Lack of efficacy (ectoparasite) - flea (4,360 reports), Application site alopecia (3,571 reports).
What drugs are most frequently associated with Domestic Shorthair adverse events? ▼
The drugs most frequently referenced in Domestic Shorthair adverse event reports are Selamectin (6,642 reports), Spinosad (6,477 reports), Fluralaner Spot-On Solution (5,905 reports), Selamectin;Sarolaner (4,234 reports), Frunevetmab (4,102 reports).
What is the average age of Domestic Shorthair in adverse event reports? ▼
The average age of Domestic Shorthair at the time of adverse event reports is 7.0 years, with an average weight of 4.9 kg (10.8 lbs).
Does a high number of adverse event reports mean Domestic Shorthair is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Domestic Shorthair safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.