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Breed profile · FDA CVM July 2026 extract

Siberian adverse-event record

Adverse-event filings for Siberian (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#224 of 510
by report volume (all breeds)
118
FDA CVM reports on file
4.2%
death-coded share of reports
#169 of 275
by death-coded share (≥50 reports)

How the 118 reports break down

By recorded gender -- every report on file for Siberian, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 21 15.75 10.5 5.25 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Siberian drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Siberian ranks #224 of 510 by total reports (118) and #169 of 275 by death-coded share (4.2%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#224
This breed, reports of 510
#169
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Siberian has 118 reports now versus 116 in that prior snapshot: 2 more (1.7%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Siberian changes

Total Reports

118

Above-median volume

Deaths Reported

5

of 118 reports

Death-coded share of reports

4.2%

Below-median death-coded share

Avg Age at Report

5.8 yr

5.1 kg avg weight

Death-Coded Outcome Share

Siberian death-coded reports 4.2%
Cross-breed median

4.2% of 118 siberian reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Siberian's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

4% 39th percentile Higher share than 39% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Siberian 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 5.1 kg (11.2 lbs)

Top Reported Reactions

Vomiting 16
Lack of efficacy (ectoparasite) - flea 15
Behavioural disorder NOS 13
Lethargy (see also Central nervous system depression in 'Neurological') 13
Not eating 11
Hyperactivity 10
Panting 8
Emesis (multiple) 8

Most Referenced Drugs

Fluralaner Spot-On Solution 23
Spinosad 15
Nitenpyram 12
Buprenorphine 11
Velagliflozin Proline Monohydrate 8
Fluralaner/Moxidectin Spot-On 7
Lotilaner 6
Bexagliflozin 6

Outcome Breakdown

Ongoing
43 (35.5%)
Outcome Unknown
35 (28.9%)
Recovered/Normal
34 (28.1%)
Recovered with Sequela
4 (3.3%)
Died
3 (2.5%)
Euthanized
2 (1.7%)

Gender Distribution

Male 69 (58.5%)
Female 44 (37.3%)
Unknown 5 (4.2%)

Reports by Year

Year Reports Trend
2012 2
2013 4
2014 2
2015 6
2016 3
2017 4
2018 7
2019 8
2020 7
2021 10
2022 11
2023 13
2024 21
2025 18
2026 2

Siberian FDA adverse-event insights

Signature read: death-coded share at 4.2% is the standout outcome stamp on Siberian's FDA row. According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Siberian sits at #224 of 510 by report volume among all breeds and #23 of 55 among cat breeds, with 118 reports and 5 (4.2%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #169 of 275. Mean age at report: 5.8 years, average weight 5.1 kg (11.2 lbs).

Top reported signs: Vomiting (16), Lack of efficacy (ectoparasite) - flea (15), Behavioural disorder NOS (13). Most-referenced drug: Fluralaner Spot-On Solution (23 reports), followed by Spinosad (15) and Nitenpyram (12).

Outcome coding on 121 status-recorded reports is dominated by Ongoing (35.5%). Annual submissions ranged 2-2,026 across 15 years on file.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Tonkinese
118 reports · 11.9% death-coded
Bombay
116 reports · 7.8% death-coded
Snowshoe
114 reports · 7.0% death-coded
Rex - Devon
88 reports · 13.6% death-coded
Scottish Fold Longhair
83 reports · 4.8% death-coded
British cat
79 reports · 3.8% death-coded

Nationwide breeds with similar profiles

Two openFDA-derived peer sets for Siberian, both outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (4.2% death-coded here).

Spaniel - King Charles Cavalier 4.2% · Dog Mountain Dog - Bernese 4.2% · Dog Corgi (unspecified) 4.2% · Dog Dog (other) 4.3% · Dog

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Siberian? ▼
There are 118 adverse event reports involving Siberian in the FDA database, of which 5 were death-coded (4.2% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Siberian ranks #224 of 510 by report volume among all breeds PlainBreed indexes (#23 of 55 among cat breeds).
Where does Siberian sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Siberian is #224 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #23 of 55. Among breeds with at least 50 reports, its death-coded share ranks #169 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Siberian? ▼
The most commonly reported adverse reactions for Siberian are Vomiting (16 reports), Lack of efficacy (ectoparasite) - flea (15 reports), Behavioural disorder NOS (13 reports), Lethargy (see also Central nervous system depression in 'Neurological') (13 reports), Not eating (11 reports).
What drugs are most frequently associated with Siberian adverse events? ▼
The drugs most frequently referenced in Siberian adverse event reports are Fluralaner Spot-On Solution (23 reports), Spinosad (15 reports), Nitenpyram (12 reports), Buprenorphine (11 reports), Velagliflozin Proline Monohydrate (8 reports).
What is the average age of Siberian in adverse event reports? ▼
The average age of Siberian at the time of adverse event reports is 5.8 years, with an average weight of 5.1 kg (11.2 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Siberian (Cat), extract as of July 2026 extract. 118 reports · 5 death-coded (4.2% of reports, not a mortality rate) · #224 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →