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Breed profile · FDA CVM July 2026 extract

Crossbred Feline/cat adverse-event record

Adverse-event filings for Crossbred Feline/cat (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#133 of 510
by report volume (all breeds)
571
FDA CVM reports on file
6.3%
death-coded share of reports
#98 of 275
by death-coded share (≥50 reports)

How the 571 reports break down

By recorded gender -- every report on file for Crossbred Feline/cat, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 73 54.75 36.5 18.25 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Crossbred Feline/cat drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Crossbred Feline/cat ranks #133 of 510 by total reports (571) and #98 of 275 by death-coded share (6.3%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#133
This breed, reports of 510
#98
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Crossbred Feline/cat has 571 reports now versus 562 in that prior snapshot: 9 more (1.6%).

Report change
+9
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Crossbred Feline/cat changes

Total Reports

571

Above-median volume

Deaths Reported

36

of 571 reports

Death-coded share of reports

6.3%

Above-median death-coded share

Avg Age at Report

6.7 yr

5.0 kg avg weight

Breed Safety Scorecard

F (28/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
6.3%

Share of reports coded as a fatality

Euthanasia rate F
3.3%

Share of reports resulting in euthanasia

Full recovery rate F
25.6%

Share of reports coded "Recovered/Normal"

5-year trend F
+43%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Crossbred Feline/cat death-coded reports 6.3%
Cross-breed median

6.3% of 571 crossbred feline/cat reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Crossbred Feline/cat's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

6% 64th percentile Higher share than 64% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Crossbred Feline/cat 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 5.0 kg (11.0 lbs)

Top Reported Reactions

Lack of efficacy (ectoparasite) - flea 94
Lethargy (see also Central nervous system depression in 'Neurological') 59
Application site hair loss 58
Vomiting 53
Diarrhoea 32
Not eating 31
Behavioural disorder NOS 30
Emesis (multiple) 27

Most Referenced Drugs

Fluralaner Spot-On Solution 188
Nitenpyram 65
Fluralaner/Moxidectin Spot-On 52
Spinosad 43
Selamectin;Sarolaner 40
Selamectin 21
Eprinomectin + Esafoxolaner + Praziquantel 21
Imidacloprid + Moxidectin 15

Outcome Breakdown

Ongoing
234 (40.9%)
Outcome Unknown
147 (25.7%)
Recovered/Normal
146 (25.5%)
Euthanized
19 (3.3%)
Died
17 (3.0%)
Recovered with Sequela
9 (1.6%)

Gender Distribution

Female 266 (46.6%)
Male 266 (46.6%)
Unknown 25 (4.4%)
Mixed 14 (2.5%)

Reports by Year

Year Reports Trend
2010 1
2011 3
2012 13
2013 10
2014 25
2015 30
2016 13
2017 53
2018 65
2019 39
2020 47
2021 51
2022 39
2023 58
2024 46
2025 73
2026 5

Crossbred Feline/cat: high-volume FDA adverse-event cohort

Signature read: 571 reports place Crossbred Feline/cat in the upper third of breed filing volume (#133 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Crossbred Feline/cat sits at #133 of 510 by report volume among all breeds and #14 of 55 among cat breeds, with 571 reports and 36 (6.3%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #98 of 275. Mean age at report: 6.7 years, average weight 5.0 kg (11.0 lbs).

Top reported signs: Lack of efficacy (ectoparasite) - flea (94), Lethargy (see also Central nervous system depression in 'Neurological') (59), Application site hair loss (58). Most-referenced drug: Fluralaner Spot-On Solution (188 reports), followed by Nitenpyram (65) and Fluralaner/Moxidectin Spot-On (52).

Outcome coding on 572 status-recorded reports is dominated by Ongoing (40.9%). Annual submissions ranged 1-2,026 across 17 years on file.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Russian
611 reports · 7.2% death-coded
Himalayan
640 reports · 10.6% death-coded
Bengal
673 reports · 4.6% death-coded
American Shorthair
442 reports · 7.5% death-coded
Mixed (Cat)
298 reports · 10.7% death-coded
Manx
284 reports · 11.3% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Crossbred Feline/cat drawn from openFDA outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (6.3% death-coded here).

Bullmastiff 6.4% · Dog Mastiff 6.2% · Dog Chow Chow 6.4% · Dog Dogue de Bordeaux 6.2% · Dog

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Crossbred Feline/cat? ▼
There are 571 adverse event reports involving Crossbred Feline/cat in the FDA database, of which 36 were death-coded (6.3% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Crossbred Feline/cat ranks #133 of 510 by report volume among all breeds PlainBreed indexes (#14 of 55 among cat breeds).
Where does Crossbred Feline/cat sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Crossbred Feline/cat is #133 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #14 of 55. Among breeds with at least 50 reports, its death-coded share ranks #98 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Crossbred Feline/cat? ▼
The most commonly reported adverse reactions for Crossbred Feline/cat are Lack of efficacy (ectoparasite) - flea (94 reports), Lethargy (see also Central nervous system depression in 'Neurological') (59 reports), Application site hair loss (58 reports), Vomiting (53 reports), Diarrhoea (32 reports).
What drugs are most frequently associated with Crossbred Feline/cat adverse events? ▼
The drugs most frequently referenced in Crossbred Feline/cat adverse event reports are Fluralaner Spot-On Solution (188 reports), Nitenpyram (65 reports), Fluralaner/Moxidectin Spot-On (52 reports), Spinosad (43 reports), Selamectin;Sarolaner (40 reports).
What is the average age of Crossbred Feline/cat in adverse event reports? ▼
The average age of Crossbred Feline/cat at the time of adverse event reports is 6.7 years, with an average weight of 5.0 kg (11.0 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Crossbred Feline/cat (Cat), extract as of July 2026 extract. 571 reports · 36 death-coded (6.3% of reports, not a mortality rate) · #133 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →