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2026 FDA CVM data 548 reports on file official source

Crossbred Feline/cat — FDA Adverse Event Profile

Adverse-event records and label data for Crossbred Feline/cat (Cat), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.

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Annual breed adverse-event registration timeline Bar chart showing yearly FDA Center for Veterinary Medicine adverse event report counts per breed registry cohort, with paw-print tick marks indicating count buckets. 65 48.75 32.5 16.25 0 2018 2019 2020 2021 2022 2023 2024 2025 Reports filed Death-coded reports
Annual report volume for Crossbred Feline/cat drawn from FDA CVM filings.

Crossbred Feline/cat (Cat) has 548 FDA adverse event reports on record, with 35 deaths reported (640.0% death rate) — ranking #134 by report volume. The most frequently reported reaction is Lack of efficacy (ectoparasite) - flea (89 cases). The top associated drug is Fluralaner Spot-On Solution. Average age at report: 6.7 years.

Total Reports

548

FDA CVM filings

Deaths Reported

35

of 548 reports

Death Rate

640.0%

death-coded share

Avg Age at Report

6.7 yr

5.0 kg avg weight

Death-Coded Outcome Share

Crossbred Feline/cat death-coded reports 100.0%
Database median

640.0% of 548 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Average weight at time of report: 5.0 kg (11.0 lbs)

Top Reported Reactions

Lack of efficacy (ectoparasite) - flea 89
Lethargy (see also Central nervous system depression in 'Neurological') 59
Application site hair loss 55
Vomiting 53
Diarrhoea 32
Not eating 31
Behavioural disorder NOS 27
Emesis (multiple) 27
Anorexia 26
Panting 24
Hyperactivity 22
Ataxia 21
Fever 21
Decreased appetite 21
Lethargy (see also Central nervous system depression in Neurological) 20

Most Referenced Drugs

Fluralaner Spot-On Solution 185
Nitenpyram 64
Fluralaner/Moxidectin Spot-On 48
Spinosad 43
Selamectin;Sarolaner 35
Selamectin 21
Eprinomectin + Esafoxolaner + Praziquantel 20
Imidacloprid + Moxidectin 15
Cefovecin 11
Robenacoxib 9
Emodepside + Praziquantel 8
Buprenorphine 8
Frunevetmab 8
Velagliflozin Proline Monohydrate 8
Mirtazapine 7

Outcome Breakdown

Ongoing
226 (41.2%)
Recovered/Normal
141 (25.7%)
Outcome Unknown
139 (25.3%)
Euthanized
19 (3.5%)
Died
16 (2.9%)
Recovered with Sequela
8 (1.5%)

Gender Distribution

Female 255 (46.5%)
Male 255 (46.5%)
Unknown 24 (4.4%)
Mixed 14 (2.6%)

Reports by Year

Year Reports Trend
2010 1
2011 3
2012 13
2013 10
2014 25
2015 30
2016 13
2017 53
2018 65
2019 39
2020 47
2021 50
2022 39
2023 58
2024 46
2025 56
Size-class weight distribution across registered breeds Vertical bar chart showing the distribution of registered breeds across five size classes (Toy, Small, Medium, Large, Giant), each represented by a scaled dog-silhouette and a count value. 118 89 59 30 0 Breeds in class 38 Toy 0–6 kg Chihuahua 64 Small 6–14 kg Beagle 92 Medium 14–27 kg Border Collie 118 Large 27–45 kg Labrador Retriever 41 Giant 45–90 kg Great Dane Size-Class Distribution
Where Crossbred Feline/cat sits in the registered size-class taxonomy. Average reported weight: 5.0 kg.
Breed-group distribution donut chart Donut chart with kennel-club-ribbon center showing breed counts across the eight standard breed groups (Sporting, Hound, Working, Terrier, Toy, Non-Sporting, Herding, Miscellaneous). CH Sporting 32 · 14.2% Hound 36 · 15.9% Working 33 · 14.6% Terrier 31 · 13.7% Toy 23 · 10.2% Non-Sporting 21 · 9.3% Herding 32 · 14.2% Misc. 18 · 8.0% Breed-Group Classification 226 breeds across 8 taxonomic groups
Eight standard breed-group classifications used by major registries (AKC's seven groups plus Miscellaneous). Provides taxonomic context for breed lookups.

Crossbred Feline/cat Pet Health Insights

Across the FDA Center for Veterinary Medicine adverse event database, Crossbred Feline/cat accounts for 548 submitted reports and currently ranks #134 by report volume within the cat population. Of those reports, 35 involved a death outcome — a 640.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 6.7 years, with an average recorded body weight of 5.0 kg (11.0 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.

The most frequently reported clinical signs for Crossbred Feline/cat are Lack of efficacy (ectoparasite) - flea (89 reports), Lethargy (see also Central nervous system depression in 'Neurological') (59 reports), Application site hair loss (55 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Fluralaner Spot-On Solution appears in 185 reports and is the single most-referenced drug, followed by Nitenpyram (64) and Fluralaner/Moxidectin Spot-On (48). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same cat species.

Outcome coding on the 549 reports with a recorded status is dominated by Ongoing (41.2% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual cat.

Understanding Crossbred Feline/cat Adverse Event Data

Crossbred Feline/cat has a moderate volume of adverse event reports (548). Report counts are influenced by breed popularity, owner awareness, and veterinary reporting practices.

The 640.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.

The most frequently referenced drug in adverse reports is Fluralaner Spot-On Solution, appearing in 185 reports. This may indicate widespread use of the medication rather than a specific safety concern for Crossbred Feline/cat.

Other Cat Breeds

Frequently Asked Questions

How many FDA adverse event reports involve Crossbred Feline/cat?
There are 548 adverse event reports involving Crossbred Feline/cat in the FDA database, with 35 reports involving death (640.0% death rate). Crossbred Feline/cat ranks #134 by report volume.
What are the most common adverse reactions reported for Crossbred Feline/cat?
The most commonly reported adverse reactions for Crossbred Feline/cat are Lack of efficacy (ectoparasite) - flea (89 reports), Lethargy (see also Central nervous system depression in 'Neurological') (59 reports), Application site hair loss (55 reports), Vomiting (53 reports), Diarrhoea (32 reports).
What drugs are most frequently associated with Crossbred Feline/cat adverse events?
The drugs most frequently referenced in Crossbred Feline/cat adverse event reports are Fluralaner Spot-On Solution (185 reports), Nitenpyram (64 reports), Fluralaner/Moxidectin Spot-On (48 reports), Spinosad (43 reports), Selamectin;Sarolaner (35 reports).
What is the average age of Crossbred Feline/cat in adverse event reports?
The average age of Crossbred Feline/cat at the time of adverse event reports is 6.7 years, with an average weight of 5.0 kg (11.0 lbs).
Does a high number of adverse event reports mean Crossbred Feline/cat is unhealthy?
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Crossbred Feline/cat safety data come from?
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.

Guides & Resources

Related Data Sources

Data Sources & Methodology

Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.

Crossbred Feline/cat ranks #134 by total report volume. Death rate (640.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial