Total Reports
548
FDA CVM filings
Cat /
FDA CVM · 2025 release 548 reports on file
Crossbred Feline/cat - FDA Adverse Event Profile
Adverse-event records for Crossbred Feline/cat (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among cat breeds, Crossbred Feline/cat is #134 by FDA report volume; 6.4% of its 548 reports (35) were death-coded.
- #134
- most-reported cat breed
- 6.4%
- death-coded report share
- 89
- Lack of efficacy (ectoparasite) - flea - top reaction
- 6.7 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
35
of 548 reports
Death Rate
6.4%
death-coded share
Avg Age at Report
6.7 yr
5.0 kg avg weight
Death-Coded Outcome Share
Crossbred Feline/cat death-coded reports 6.4%
Cross-breed median
6.4% of 548 crossbred feline/cat reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 5.0 kg (11.0 lbs)
Top Reported Reactions
Lack of efficacy (ectoparasite) - flea 89
Lethargy (see also Central nervous system depression in 'Neurological') 59
Application site hair loss 55
Vomiting 53
Diarrhoea 32
Not eating 31
Behavioural disorder NOS 27
Emesis (multiple) 27
Most Referenced Drugs
Fluralaner Spot-On Solution 185
Nitenpyram 64
Fluralaner/Moxidectin Spot-On 48
Spinosad 43
Selamectin;Sarolaner 35
Selamectin 21
Eprinomectin + Esafoxolaner + Praziquantel 20
Imidacloprid + Moxidectin 15
Outcome Breakdown
Ongoing
226 (41.2%)
Recovered/Normal
141 (25.7%)
Outcome Unknown
139 (25.3%)
Euthanized
19 (3.5%)
Died
16 (2.9%)
Recovered with Sequela
8 (1.5%)
Gender Distribution
Female 255 (46.5%)
Male 255 (46.5%)
Unknown 24 (4.4%)
Mixed 14 (2.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 3 | |
| 2012 | 13 | |
| 2013 | 10 | |
| 2014 | 25 | |
| 2015 | 30 | |
| 2016 | 13 | |
| 2017 | 53 | |
| 2018 | 65 | |
| 2019 | 39 | |
| 2020 | 47 | |
| 2021 | 50 | |
| 2022 | 39 | |
| 2023 | 58 | |
| 2024 | 46 | |
| 2025 | 56 | |
Crossbred Feline/cat Pet Health Insights
Crossbred Feline/cat accounts for 548 FDA adverse event reports, ranking #134 by volume among cat breeds, with 35 reports (6.4%) coded as a death outcome. Mean age at report: 6.7 years, average weight 5.0 kg (11.0 lbs).
Top reported signs: Lack of efficacy (ectoparasite) - flea (89), Lethargy (see also Central nervous system depression in 'Neurological') (59), Application site hair loss (55). Most-referenced drug: Fluralaner Spot-On Solution (185 reports), followed by Nitenpyram (64) and Fluralaner/Moxidectin Spot-On (48).
Outcome coding on 549 status-recorded reports is dominated by Ongoing (41.2%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Crossbred Feline/cat? ▼
There are 548 adverse event reports involving Crossbred Feline/cat in the FDA database, with 35 reports involving death (6.4% death rate). Crossbred Feline/cat ranks #134 by report volume.
What are the most common adverse reactions reported for Crossbred Feline/cat? ▼
The most commonly reported adverse reactions for Crossbred Feline/cat are Lack of efficacy (ectoparasite) - flea (89 reports), Lethargy (see also Central nervous system depression in 'Neurological') (59 reports), Application site hair loss (55 reports), Vomiting (53 reports), Diarrhoea (32 reports).
What drugs are most frequently associated with Crossbred Feline/cat adverse events? ▼
The drugs most frequently referenced in Crossbred Feline/cat adverse event reports are Fluralaner Spot-On Solution (185 reports), Nitenpyram (64 reports), Fluralaner/Moxidectin Spot-On (48 reports), Spinosad (43 reports), Selamectin;Sarolaner (35 reports).
What is the average age of Crossbred Feline/cat in adverse event reports? ▼
The average age of Crossbred Feline/cat at the time of adverse event reports is 6.7 years, with an average weight of 5.0 kg (11.0 lbs).
Does a high number of adverse event reports mean Crossbred Feline/cat is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Crossbred Feline/cat safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.