Total Reports
273
FDA CVM filings
Cat /
2026 FDA CVM data 273 reports on file official source
Manx — FDA Adverse Event Profile
Adverse-event records and label data for Manx (Cat), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.
Manx (Cat) has 273 FDA adverse event reports on record, with 31 deaths reported (1140.0% death rate) — ranking #171 by report volume. The most frequently reported reaction is Vomiting (44 cases). The top associated drug is Spinosad. Average age at report: 7.2 years.
Deaths Reported
31
of 273 reports
Death Rate
1140.0%
death-coded share
Avg Age at Report
7.2 yr
4.9 kg avg weight
Death-Coded Outcome Share
Manx death-coded reports 100.0%
Database median
1140.0% of 273 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.9 kg (10.8 lbs)
Top Reported Reactions
Vomiting 44
Lethargy (see also Central nervous system depression in 'Neurological') 33
Emesis 26
Anorexia 23
Lack of efficacy (ectoparasite) - flea 22
Lack of efficacy - NOS 20
Application site hair loss 20
Diarrhoea 18
Weight loss 18
Death by euthanasia 16
Death 15
Hypersalivation 13
Application site alopecia 13
Dehydration 12
Not eating 12
Most Referenced Drugs
Spinosad 48
Selamectin 32
Fluralaner Spot-On Solution 25
Cefovecin 24
Selamectin;Sarolaner 22
Frunevetmab 21
Imidacloprid + Moxidectin 17
Nitenpyram 13
Maropitant Citrate 9
Bexagliflozin 8
Meloxicam 7
Mirtazapine 7
Buprenorphine 7
Emodepside + Praziquantel 6
Robenacoxib 6
Outcome Breakdown
Ongoing
87 (34.0%)
Outcome Unknown
71 (27.7%)
Recovered/Normal
64 (25.0%)
Died
17 (6.6%)
Euthanized
14 (5.5%)
Recovered with Sequela
3 (1.2%)
Gender Distribution
Male 141 (51.6%)
Female 126 (46.2%)
Unknown 4 (1.5%)
Mixed 2 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 12 | |
| 2011 | 8 | |
| 2012 | 16 | |
| 2013 | 21 | |
| 2014 | 21 | |
| 2015 | 13 | |
| 2016 | 16 | |
| 2017 | 23 | |
| 2018 | 16 | |
| 2019 | 20 | |
| 2020 | 11 | |
| 2021 | 17 | |
| 2022 | 13 | |
| 2023 | 27 | |
| 2024 | 29 | |
| 2025 | 10 | |
Manx Pet Health Insights
Across the FDA Center for Veterinary Medicine adverse event database, Manx accounts for 273 submitted reports and currently ranks #171 by report volume within the cat population. Of those reports, 31 involved a death outcome — a 1140.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 7.2 years, with an average recorded body weight of 4.9 kg (10.8 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.
The most frequently reported clinical signs for Manx are Vomiting (44 reports), Lethargy (see also Central nervous system depression in 'Neurological') (33 reports), Emesis (26 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Spinosad appears in 48 reports and is the single most-referenced drug, followed by Selamectin (32) and Fluralaner Spot-On Solution (25). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same cat species.
Outcome coding on the 256 reports with a recorded status is dominated by Ongoing (34.0% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual cat.
Understanding Manx Adverse Event Data
Manx has 273 adverse event reports on file. Lower report volumes may reflect a less common breed, lower reporting rates, or genuinely fewer adverse events.
The 1140.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.
The most frequently referenced drug in adverse reports is Spinosad, appearing in 48 reports. This may indicate widespread use of the medication rather than a specific safety concern for Manx.
Other Cat Breeds
Domestic Shorthair
61,410 reports · 720.0% death rate
Cat (unknown)
12,555 reports · 930.0% death rate
Domestic Longhair
9,078 reports · 690.0% death rate
Domestic (unspecified)
7,559 reports · 1340.0% death rate
Domestic Mediumhair
6,057 reports · 760.0% death rate
Cat (other)
4,619 reports · 970.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Manx? ▼
There are 273 adverse event reports involving Manx in the FDA database, with 31 reports involving death (1140.0% death rate). Manx ranks #171 by report volume.
What are the most common adverse reactions reported for Manx? ▼
The most commonly reported adverse reactions for Manx are Vomiting (44 reports), Lethargy (see also Central nervous system depression in 'Neurological') (33 reports), Emesis (26 reports), Anorexia (23 reports), Lack of efficacy (ectoparasite) - flea (22 reports).
What drugs are most frequently associated with Manx adverse events? ▼
The drugs most frequently referenced in Manx adverse event reports are Spinosad (48 reports), Selamectin (32 reports), Fluralaner Spot-On Solution (25 reports), Cefovecin (24 reports), Selamectin;Sarolaner (22 reports).
What is the average age of Manx in adverse event reports? ▼
The average age of Manx at the time of adverse event reports is 7.2 years, with an average weight of 4.9 kg (10.8 lbs).
Does a high number of adverse event reports mean Manx is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Manx safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Guides & Resources
Understanding Adverse Events
What FDA reports are and how they are collected
Breed-Specific Risks
Why some breeds appear in more adverse event reports
Pet Medication Safety
Evaluating medication risks using FDA data
Most Reported Medications
Drugs that appear most in adverse event reports
How FDA CVM Tracks Events
The reporting process and database limitations
Related Data Sources
Data Sources & Methodology
Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.
Manx ranks #171 by total report volume. Death rate (1140.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.
Read our methodology — how this data is sourced, computed, and verified.
Related
Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial