Total Reports
273
FDA CVM filings
Cat /
FDA CVM · 2025 release 273 reports on file
Manx - FDA Adverse Event Profile
Adverse-event records for Manx (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Manx's FDA record: #171 most-reported cat breed, 273 total reports, 11.4% death-coded (31 reports).
- #171
- most-reported cat breed
- 11.4%
- death-coded report share
- 44
- Vomiting - top reaction
- 7.2 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
31
of 273 reports
Death Rate
11.4%
death-coded share
Avg Age at Report
7.2 yr
4.9 kg avg weight
Death-Coded Outcome Share
Manx death-coded reports 11.4%
Cross-breed median
11.4% of 273 manx reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.9 kg (10.8 lbs)
Top Reported Reactions
Vomiting 44
Lethargy (see also Central nervous system depression in 'Neurological') 33
Emesis 26
Anorexia 23
Lack of efficacy (ectoparasite) - flea 22
Lack of efficacy - NOS 20
Application site hair loss 20
Diarrhoea 18
Most Referenced Drugs
Spinosad 48
Selamectin 32
Fluralaner Spot-On Solution 25
Cefovecin 24
Selamectin;Sarolaner 22
Frunevetmab 21
Imidacloprid + Moxidectin 17
Nitenpyram 13
Outcome Breakdown
Ongoing
87 (34.0%)
Outcome Unknown
71 (27.7%)
Recovered/Normal
64 (25.0%)
Died
17 (6.6%)
Euthanized
14 (5.5%)
Recovered with Sequela
3 (1.2%)
Gender Distribution
Male 141 (51.6%)
Female 126 (46.2%)
Unknown 4 (1.5%)
Mixed 2 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 12 | |
| 2011 | 8 | |
| 2012 | 16 | |
| 2013 | 21 | |
| 2014 | 21 | |
| 2015 | 13 | |
| 2016 | 16 | |
| 2017 | 23 | |
| 2018 | 16 | |
| 2019 | 20 | |
| 2020 | 11 | |
| 2021 | 17 | |
| 2022 | 13 | |
| 2023 | 27 | |
| 2024 | 29 | |
| 2025 | 10 | |
Manx Pet Health Insights
Manx accounts for 273 FDA adverse event reports, ranking #171 by volume among cat breeds, with 31 reports (11.4%) coded as a death outcome. Mean age at report: 7.2 years, average weight 4.9 kg (10.8 lbs).
Top reported signs: Vomiting (44), Lethargy (see also Central nervous system depression in 'Neurological') (33), Emesis (26). Most-referenced drug: Spinosad (48 reports), followed by Selamectin (32) and Fluralaner Spot-On Solution (25).
Outcome coding on 256 status-recorded reports is dominated by Ongoing (34.0%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Manx? ▼
There are 273 adverse event reports involving Manx in the FDA database, with 31 reports involving death (11.4% death rate). Manx ranks #171 by report volume.
What are the most common adverse reactions reported for Manx? ▼
The most commonly reported adverse reactions for Manx are Vomiting (44 reports), Lethargy (see also Central nervous system depression in 'Neurological') (33 reports), Emesis (26 reports), Anorexia (23 reports), Lack of efficacy (ectoparasite) - flea (22 reports).
What drugs are most frequently associated with Manx adverse events? ▼
The drugs most frequently referenced in Manx adverse event reports are Spinosad (48 reports), Selamectin (32 reports), Fluralaner Spot-On Solution (25 reports), Cefovecin (24 reports), Selamectin;Sarolaner (22 reports).
What is the average age of Manx in adverse event reports? ▼
The average age of Manx at the time of adverse event reports is 7.2 years, with an average weight of 4.9 kg (10.8 lbs).
Does a high number of adverse event reports mean Manx is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Manx safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.