Total Reports
411
FDA CVM filings
Cat /
FDA CVM · 2025 release 411 reports on file
American Shorthair - FDA Adverse Event Profile
Adverse-event records for American Shorthair (Cat) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among cat breeds, American Shorthair is #151 by FDA report volume; 7.5% of its 411 reports (31) were death-coded.
- #151
- most-reported cat breed
- 7.5%
- death-coded report share
- 64
- Vomiting - top reaction
- 7.1 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
31
of 411 reports
Death Rate
7.5%
death-coded share
Avg Age at Report
7.1 yr
5.2 kg avg weight
Death-Coded Outcome Share
American Shorthair death-coded reports 7.5%
Cross-breed median
7.5% of 411 american shorthair reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 5.2 kg (11.5 lbs)
Top Reported Reactions
Vomiting 64
Lack of efficacy (ectoparasite) - flea 42
Emesis 30
Application site hair loss 29
Behavioural disorder NOS 28
Lethargy (see also Central nervous system depression in 'Neurological') 27
Application site alopecia 24
Hypersalivation 23
Most Referenced Drugs
Spinosad 59
Selamectin 49
Fluralaner Spot-On Solution 43
Imidacloprid + Moxidectin 22
Buprenorphine 20
Nitenpyram 19
Fluralaner/Moxidectin Spot-On 18
Porcine Insulin 17
Outcome Breakdown
Outcome Unknown
120 (32.3%)
Recovered/Normal
111 (29.9%)
Ongoing
105 (28.3%)
Died
19 (5.1%)
Euthanized
12 (3.2%)
Recovered with Sequela
4 (1.1%)
Gender Distribution
Male 229 (55.7%)
Female 174 (42.3%)
Unknown 4 (1.0%)
Mixed 4 (1.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 37 | |
| 2011 | 3 | |
| 2012 | 24 | |
| 2013 | 27 | |
| 2014 | 33 | |
| 2015 | 24 | |
| 2016 | 9 | |
| 2017 | 16 | |
| 2018 | 20 | |
| 2019 | 24 | |
| 2020 | 12 | |
| 2021 | 12 | |
| 2022 | 11 | |
| 2023 | 33 | |
| 2024 | 77 | |
| 2025 | 49 | |
American Shorthair Pet Health Insights
American Shorthair accounts for 411 FDA adverse event reports, ranking #151 by volume among cat breeds, with 31 reports (7.5%) coded as a death outcome. Mean age at report: 7.1 years, average weight 5.2 kg (11.5 lbs).
Top reported signs: Vomiting (64), Lack of efficacy (ectoparasite) - flea (42), Emesis (30). Most-referenced drug: Spinosad (59 reports), followed by Selamectin (49) and Fluralaner Spot-On Solution (43).
Outcome coding on 371 status-recorded reports is dominated by Outcome Unknown (32.3%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Cat Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve American Shorthair? ▼
There are 411 adverse event reports involving American Shorthair in the FDA database, with 31 reports involving death (7.5% death rate). American Shorthair ranks #151 by report volume.
What are the most common adverse reactions reported for American Shorthair? ▼
The most commonly reported adverse reactions for American Shorthair are Vomiting (64 reports), Lack of efficacy (ectoparasite) - flea (42 reports), Emesis (30 reports), Application site hair loss (29 reports), Behavioural disorder NOS (28 reports).
What drugs are most frequently associated with American Shorthair adverse events? ▼
The drugs most frequently referenced in American Shorthair adverse event reports are Spinosad (59 reports), Selamectin (49 reports), Fluralaner Spot-On Solution (43 reports), Imidacloprid + Moxidectin (22 reports), Buprenorphine (20 reports).
What is the average age of American Shorthair in adverse event reports? ▼
The average age of American Shorthair at the time of adverse event reports is 7.1 years, with an average weight of 5.2 kg (11.5 lbs).
Does a high number of adverse event reports mean American Shorthair is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this American Shorthair safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.