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Breed profile · FDA CVM July 2026 extract

American Shorthair adverse-event record

Adverse-event filings for American Shorthair (Cat) in the FDA Center for Veterinary Medicine openFDA extract. Browse cat breeds, reactions, and outcomes below.

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#149 of 510
by report volume (all breeds)
442
FDA CVM reports on file
7.5%
death-coded share of reports
#79 of 275
by death-coded share (≥50 reports)

How the 442 reports break down

By recorded gender -- every report on file for American Shorthair, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 77 57.75 38.5 19.25 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for American Shorthair drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, American Shorthair ranks #149 of 510 by total reports (442) and #79 of 275 by death-coded share (7.5%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#149
This breed, reports of 510
#79
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. American Shorthair has 442 reports now versus 430 in that prior snapshot: 12 more (2.8%).

Report change
+12
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to American Shorthair changes

Total Reports

442

Above-median volume

Deaths Reported

33

of 442 reports

Death-coded share of reports

7.5%

Above-median death-coded share

Avg Age at Report

7.1 yr

5.2 kg avg weight

Breed Safety Scorecard

F (24/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
7.5%

Share of reports coded as a fatality

Euthanasia rate F
2.9%

Share of reports resulting in euthanasia

Full recovery rate D
26.7%

Share of reports coded "Recovered/Normal"

5-year trend F
+500%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

American Shorthair death-coded reports 7.5%
Cross-breed median

7.5% of 442 american shorthair reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where American Shorthair's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

7% 71st percentile Higher share than 71% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. American Shorthair 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 5.2 kg (11.5 lbs)

Top Reported Reactions

Vomiting 67
Lack of efficacy (ectoparasite) - flea 50
Application site hair loss 32
Emesis 30
Behavioural disorder NOS 29
Lethargy (see also Central nervous system depression in 'Neurological') 27
Application site alopecia 25
Lack of efficacy - NOS 24

Most Referenced Drugs

Spinosad 59
Fluralaner Spot-On Solution 53
Selamectin 50
Buprenorphine 22
Imidacloprid + Moxidectin 22
Fluralaner/Moxidectin Spot-On 21
Nitenpyram 19
Robenacoxib 18

Outcome Breakdown

Outcome Unknown
129 (32.1%)
Ongoing
118 (29.4%)
Recovered/Normal
118 (29.4%)
Died
20 (5.0%)
Euthanized
13 (3.2%)
Recovered with Sequela
4 (1.0%)

Gender Distribution

Male 252 (57.0%)
Female 181 (41.0%)
Unknown 5 (1.1%)
Mixed 4 (0.9%)

Reports by Year

Year Reports Trend
2010 37
2011 3
2012 24
2013 27
2014 33
2015 24
2016 9
2017 16
2018 20
2019 24
2020 12
2021 12
2022 11
2023 33
2024 77
2025 72
2026 8

American Shorthair: high death-coded share in the FDA CVM extract

Signature read: American Shorthair's 7.5% death-coded share is in the upper third of the ≥50-report cohort (median 4.8%). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, American Shorthair sits at #149 of 510 by report volume among all breeds and #15 of 55 among cat breeds, with 442 reports and 33 (7.5%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #79 of 275. Mean age at report: 7.1 years, average weight 5.2 kg (11.5 lbs).

Top reported signs: Vomiting (67), Lack of efficacy (ectoparasite) - flea (50), Application site hair loss (32). Most-referenced drug: Spinosad (59 reports), followed by Fluralaner Spot-On Solution (53) and Selamectin (50).

Outcome coding on 402 status-recorded reports is dominated by Outcome Unknown (32.1%). Annual submissions ranged 3-2,026 across 17 years on file.

Cat Breeds With a Similar Report Volume

Showing 6 of 54 cat breeds in our dataset, ranked by closest report volume.

Crossbred Feline/cat
571 reports · 6.3% death-coded
Mixed (Cat)
298 reports · 10.7% death-coded
Manx
284 reports · 11.3% death-coded
Russian
611 reports · 7.2% death-coded
Himalayan
640 reports · 10.6% death-coded
American Curl Shorthair
228 reports · 3.5% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for American Shorthair drawn from openFDA outside the Cat family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (7.5% death-coded here).

Shar Pei 7.5% · Dog Terrier - Bedlington 7.7% · Dog Friesian 7.7% · Horse Saint Bernard Dog 7.7% · Dog

What to do with this cat

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve American Shorthair? ▼
There are 442 adverse event reports involving American Shorthair in the FDA database, of which 33 were death-coded (7.5% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, American Shorthair ranks #149 of 510 by report volume among all breeds PlainBreed indexes (#15 of 55 among cat breeds).
Where does American Shorthair sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, American Shorthair is #149 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Cat, it is #15 of 55. Among breeds with at least 50 reports, its death-coded share ranks #79 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for American Shorthair? ▼
The most commonly reported adverse reactions for American Shorthair are Vomiting (67 reports), Lack of efficacy (ectoparasite) - flea (50 reports), Application site hair loss (32 reports), Emesis (30 reports), Behavioural disorder NOS (29 reports).
What drugs are most frequently associated with American Shorthair adverse events? ▼
The drugs most frequently referenced in American Shorthair adverse event reports are Spinosad (59 reports), Fluralaner Spot-On Solution (53 reports), Selamectin (50 reports), Buprenorphine (22 reports), Imidacloprid + Moxidectin (22 reports).
What is the average age of American Shorthair in adverse event reports? ▼
The average age of American Shorthair at the time of adverse event reports is 7.1 years, with an average weight of 5.2 kg (11.5 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for American Shorthair (Cat), extract as of July 2026 extract. 442 reports · 33 death-coded (7.5% of reports, not a mortality rate) · #149 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →