Total Reports
185
FDA CVM filings
Horse /
FDA CVM · 2025 release 185 reports on file
Crossbred Equine/horse - FDA Adverse Event Profile
Adverse-event records for Crossbred Equine/horse (Horse) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Crossbred Equine/horse ranks #187 by report volume among horse breeds - 13 of 185 reports (7.0%) recorded a death outcome.
- #187
- most-reported horse breed
- 7.0%
- death-coded report share
- 19
- Lip oedema (see also 'Skin') - top reaction
- 14.3 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
13
of 185 reports
Death Rate
7.0%
death-coded share
Avg Age at Report
14.3 yr
416.7 kg avg weight
Death-Coded Outcome Share
Crossbred Equine/horse death-coded reports 7.0%
Cross-breed median
7.0% of 185 crossbred equine/horse reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 416.7 kg (918.8 lbs)
Top Reported Reactions
Lip oedema (see also 'Skin') 19
Lack of efficacy - NOS 18
Application site swelling 15
Diarrhoea 13
Anorexia 12
Facial oedema 10
Tongue oedema 9
Lethargy (see also Central nervous system depression in 'Neurological') 9
Most Referenced Drugs
Pergolide Mesylate 32
Ivermectin, Praziquantel 25
Omeprazole 22
Ivermectin 14
Ivermectin + Praziquantel 14
Ponazuril 5
Hyaluronic Acid 5
Flunixin Meglumine Injectable 5
Outcome Breakdown
Recovered/Normal
55 (42.3%)
Outcome Unknown
37 (28.5%)
Ongoing
25 (19.2%)
Died
7 (5.4%)
Euthanized
6 (4.6%)
Gender Distribution
Male 104 (56.2%)
Female 65 (35.1%)
Mixed 8 (4.3%)
Unknown 8 (4.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 21 | |
| 2011 | 21 | |
| 2012 | 18 | |
| 2013 | 14 | |
| 2014 | 7 | |
| 2015 | 9 | |
| 2016 | 14 | |
| 2017 | 11 | |
| 2018 | 8 | |
| 2019 | 7 | |
| 2020 | 9 | |
| 2021 | 17 | |
| 2022 | 6 | |
| 2023 | 10 | |
| 2024 | 5 | |
| 2025 | 8 | |
Crossbred Equine/horse Pet Health Insights
Crossbred Equine/horse accounts for 185 FDA adverse event reports, ranking #187 by volume among horse breeds, with 13 reports (7.0%) coded as a death outcome. Mean age at report: 14.3 years, average weight 416.7 kg (918.8 lbs).
Top reported signs: Lip oedema (see also 'Skin') (19), Lack of efficacy - NOS (18), Application site swelling (15). Most-referenced drug: Pergolide Mesylate (32 reports), followed by Ivermectin, Praziquantel (25) and Omeprazole (22).
Outcome coding on 130 status-recorded reports is dominated by Recovered/Normal (42.3%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Horse Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Crossbred Equine/horse? ▼
There are 185 adverse event reports involving Crossbred Equine/horse in the FDA database, with 13 reports involving death (7.0% death rate). Crossbred Equine/horse ranks #187 by report volume.
What are the most common adverse reactions reported for Crossbred Equine/horse? ▼
The most commonly reported adverse reactions for Crossbred Equine/horse are Lip oedema (see also 'Skin') (19 reports), Lack of efficacy - NOS (18 reports), Application site swelling (15 reports), Diarrhoea (13 reports), Anorexia (12 reports).
What drugs are most frequently associated with Crossbred Equine/horse adverse events? ▼
The drugs most frequently referenced in Crossbred Equine/horse adverse event reports are Pergolide Mesylate (32 reports), Ivermectin, Praziquantel (25 reports), Omeprazole (22 reports), Ivermectin (14 reports), Ivermectin + Praziquantel (14 reports).
What is the average age of Crossbred Equine/horse in adverse event reports? ▼
The average age of Crossbred Equine/horse at the time of adverse event reports is 14.3 years, with an average weight of 416.7 kg (918.8 lbs).
Does a high number of adverse event reports mean Crossbred Equine/horse is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Crossbred Equine/horse safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.