Reaction profile

The FDA adverse-event record for rolling

496 FDA adverse-event reports reference rolling (VeDDRA 2391). See the species, breeds, and drugs most associated with it below.

496
reports citing this reaction
9.5%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
496
Total Reports
47
Deaths
9.5%
Death Rate

Species Most Affected

Dog 333
Cat 109
Horse 47
Goat 2
Ferret 1
Chinchilla 1
Other Rodents 1
Alpaca 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 66
Terrier - Yorkshire 26
Chihuahua 23
Quarter Horse 21
Crossbred Canine/dog 20
Retriever - Labrador 19
Maltese 17
Dog (unknown) 16
Retriever - Golden 15
Cat (unknown) 13

Associated Drugs

Imidacloprid + Moxidectin 114
Buprenorphine 46
Afoxolaner 38
Selamectin 27
Nitenpyram 18
Fluralaner 13.64% 12-Week Chew 15
Ivermectin + Pyrantel As Pamoate Salt 14
Moxidectin 13
Maropitant Citrate 12
Isoflurane 12
Milbemycin Oxime + Praziquantel 11
Pyrantel Pamoate;Sarolaner 11
Bedinvetmab 11
Fluralaner Chew Tablets 10
Fluralaner Spot-On Solution 10
Sarolaner 10
Gabapentin 10
Milbemycin Oxime + Spinosad 9
Imidacloprid + Permethrin + Pyriproxyfen 9
Selamectin;Sarolaner 9

Rolling Reaction Insights

496 reports name Rolling; 47 recorded a death outcome (9.5% of reported events, not a population-level mortality rate). VeDDRA code: 2391.

By species: Dog (333 reports), Cat (109 reports), Horse (47 reports). By breed: Domestic Shorthair (66), Terrier - Yorkshire (26), Chihuahua (23).

Most co-reported drugs: Imidacloprid + Moxidectin (114 reports), Buprenorphine (46 reports), Afoxolaner (38 reports), Selamectin (27 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.