Reaction profile

The FDA adverse-event record for rolling

525 FDA reports name rolling, a high-volume reaction in the CVM extract (VeDDRA 2391). Plate stamps and neighbourhood peers follow.

#628 of 2,481
by report volume (all reactions)
525
reports citing this reaction
10.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rolling has 525 reports now versus 513 in that prior snapshot: 12 more (2.3%).

Report change
+12
Death-coded reports
+4
Death-coded share
+0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rolling changes

FDA AER · VeDDRA plate

Code 2391 VOL-MID

VOL-MID · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 525 reports
  • DEATH-ELEV 10.1%
  • MID-PACK #628/2481
  • PHOTO-FINISH Collapse of leg
  • SPECIES-DOG Dog · 348
  • DRUG-LEAD Imidacloprid + Mo… · 118
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Collapse of leg (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Rolling

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Barking · near527Rolling · this reaction525Collapse of leg · near524INEFFECTIVE, ANTIEMET… · near524Hyposthenuria · near523Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Rolling

What the FDA AER plate says about Rolling

Signature read: 525 reports place Rolling in the upper third of FDA AER volume (#628 of 2,481). Report volume is upper-third scale: 525 named reports in the openFDA extract. 53 of 525 reports were death-coded (10.1% of named reports, not a population mortality rate). Nearest volume peer: Collapse of leg (±1 reports). Lead species Dog (348). Lead co-reported drug Imidacloprid + Moxidectin (118).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Imidacloprid + Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 348
Cat 121
Horse 48
Goat 2
Ferret 1
Chinchilla 1
Other Rodents 1
Alpaca 1
Rabbit 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 74
Terrier - Yorkshire 27
Chihuahua 23
Quarter Horse 21
Crossbred Canine/dog 20
Retriever - Labrador 20
Maltese 17
Dog (unknown) 17
Cat (unknown) 16
Retriever - Golden 15

Associated Drugs

Imidacloprid + Moxidectin 118
Buprenorphine 49
Afoxolaner 40
Selamectin 28
Nitenpyram 21
Ivermectin + Pyrantel As Pamoate Salt 15
Moxidectin 15
Fluralaner 13.64% 12-Week Chew 15
Maropitant Citrate 13
Isoflurane 13
Pyrantel Pamoate;Sarolaner 13
Eprinomectin + Esafoxolaner + Praziquantel 13
Bedinvetmab 13
Milbemycin Oxime + Praziquantel 11
Gabapentin 11
Fluralaner Chew Tablets 10
Fluralaner Spot-On Solution 10
Sarolaner 10
Selamectin;Sarolaner 10
Milbemycin Oxime + Spinosad 9

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Rolling, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (525 here).

Similar death-coded share

Nearest other reactions by death-coded share (10.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rolling (#628 of 2,481 by report volume); death-coded 10.1%. PlainBreed reaction plate · report volume stamp 525 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →