Reaction profile

The FDA adverse-event record for increased sweating

230 FDA adverse-event reports reference increased sweating (VeDDRA 974). See the species, breeds, and drugs most associated with it below.

230
reports citing this reaction
10.0%
death-coded share
Horse
most-affected species
Pergolide Mesylate
most-associated drug
Verify with FDA CVM →
230
Total Reports
23
Deaths
10.0%
Death Rate

Species Most Affected

Horse 147
Human 34
Dog 27
Cat 10
Cattle 9
Donkey 3

Breeds Most Affected

Unknown 38
Quarter Horse 36
Horse (unknown) 20
Thoroughbred 17
Warmblood (unspecified) 10
Arab 8
Crossbred Equine/horse 8
Domestic Shorthair 6
Tennessee Walking Horse 4
Miniature 4

Associated Drugs

Pergolide Mesylate 30
Ceftiofur Crystalline Free Acid 14
Nitenpyram 11
Clenbuterol Hydrochloride 8
Polysulfated Glycosaminoglycan 8
Gentamicin Sulfate 8
Enrofloxacin 7
Detomidine Hydrochloride 6
Flunixin Meglumine 5
Milbemycin Oxime + Spinosad 5
Afoxolaner 5
Vit E/ Selenite Inj Solution 5
Phenylbutazone 4
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 4
Flunixin Meglumine Injectable 4
Clodronate Disodium 4
Tilmicosin 4
Oxytetracycline 3
Ponazuril 3
Dinoprost Tromethamine 3

Increased sweating Reaction Insights

230 reports name Increased sweating; 23 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). VeDDRA code: 974.

By species: Horse (147 reports), Human (34 reports), Dog (27 reports). By breed: Unknown (38), Quarter Horse (36), Horse (unknown) (20).

Most co-reported drugs: Pergolide Mesylate (30 reports), Ceftiofur Crystalline Free Acid (14 reports), Nitenpyram (11 reports), Clenbuterol Hydrochloride (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.