Reaction profile

The FDA adverse-event record for pacing

2,690 FDA adverse-event reports reference pacing (VeDDRA 2208). See the species, breeds, and drugs most associated with it below.

2,690
reports citing this reaction
9.9%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
2,690
Total Reports
267
Deaths
9.9%
Death Rate

Species Most Affected

Dog 2,354
Cat 311
Horse 23
Cattle 1
Turkey 1

Breeds Most Affected

Retriever - Labrador 271
Crossbred Canine/dog 194
Domestic Shorthair 169
Retriever - Golden 108
Shepherd Dog - German 107
Dog (unknown) 78
Chihuahua 78
Boxer (German Boxer) 66
Shepherd Dog - Australian 61
Terrier - Yorkshire 50

Associated Drugs

Afoxolaner 287
Bedinvetmab 249
Buprenorphine 176
Trilostane 157
Milbemycin Oxime + Spinosad 142
Carprofen 129
Ivermectin + Pyrantel As Pamoate Salt 127
Gabapentin 124
Pyrantel Pamoate;Sarolaner 114
Oclacitinib Maleate 104
Maropitant Citrate 94
Moxidectin 92
Imidacloprid + Moxidectin 82
Fluralaner Chew Tablets 80
Sarolaner 79
Grapiprant 73
Fluralaner 13.64% 12-Week Chew 69
Melarsomine Dihydrochloride 63
Prednisone 60
Meloxicam 55

Pacing Reaction Insights

2,690 reports name Pacing; 267 recorded a death outcome (9.9% of reported events, not a population-level mortality rate). VeDDRA code: 2208.

By species: Dog (2,354 reports), Cat (311 reports), Horse (23 reports). By breed: Retriever - Labrador (271), Crossbred Canine/dog (194), Domestic Shorthair (169).

Most co-reported drugs: Afoxolaner (287 reports), Bedinvetmab (249 reports), Buprenorphine (176 reports), Trilostane (157 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.