Reaction profile

The FDA adverse-event record for hyposthenuria

471 FDA adverse-event reports reference hyposthenuria (VeDDRA 2475). See the species, breeds, and drugs most associated with it below.

471
reports citing this reaction
8.9%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
471
Total Reports
42
Deaths
8.9%
Death Rate

Species Most Affected

Dog 440
Cat 28
Horse 3

Breeds Most Affected

Retriever - Labrador 74
Crossbred Canine/dog 30
Shepherd Dog - German 20
Retriever - Golden 18
Domestic Shorthair 18
Boxer (German Boxer) 17
Shepherd Dog - Australian 16
Beagle 10
Chihuahua 10
Terrier - Yorkshire 9

Associated Drugs

Bedinvetmab 180
Trilostane 112
Gabapentin 50
Oclacitinib Maleate 43
Carprofen 42
Maropitant Citrate 41
Anti-Il31 Mab Mcs Lot #1283563 20
Fluralaner Chew Tablets 16
Fluralaner 13.64% 12-Week Chew 16
Prednisone 15
Pyrantel Pamoate;Sarolaner 14
Tramadol 13
Grapiprant 13
Cefovecin 11
Metronidazole 11
Moxidectin 11
Doxycycline 11
Desoxycorticosterone Pivalate 9
Firocoxib 9
Sarolaner 9

Hyposthenuria Reaction Insights

471 reports name Hyposthenuria; 42 recorded a death outcome (8.9% of reported events, not a population-level mortality rate). VeDDRA code: 2475.

By species: Dog (440 reports), Cat (28 reports), Horse (3 reports). By breed: Retriever - Labrador (74), Crossbred Canine/dog (30), Shepherd Dog - German (20).

Most co-reported drugs: Bedinvetmab (180 reports), Trilostane (112 reports), Gabapentin (50 reports), Oclacitinib Maleate (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.