Reaction profile

The FDA adverse-event record for collapse of leg

498 FDA adverse-event reports reference collapse of leg (VeDDRA 1389). See the species, breeds, and drugs most associated with it below.

498
reports citing this reaction
20.1%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
498
Total Reports
100
Deaths
20.1%
Death Rate

Species Most Affected

Dog 463
Cat 28
Horse 3
Chicken 1
Rabbit 1
Alpaca 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 55
Crossbred Canine/dog 30
Retriever - Golden 26
Shepherd Dog - German 20
Dog (unknown) 18
Domestic Shorthair 18
Shih Tzu 17
Chihuahua 16
Terrier - Yorkshire 13
Terrier (unspecified) 12

Associated Drugs

Bedinvetmab 144
Sarolaner 52
Carprofen 49
Gabapentin 41
Pyrantel Pamoate;Sarolaner 37
Milbemycin Oxime + Spinosad 33
Fluralaner 13.64% 12-Week Chew 27
Fluralaner Chew Tablets 26
Afoxolaner 21
Tramadol 19
Grapiprant 18
Polysulfated Glycosaminoglycan 17
Oclacitinib Maleate 16
Moxidectin 14
Frunevetmab 13
Trilostane 12
Anti-Il31 Mab Mcs Lot #1283563 12
Spinosad 11
Prednisone 11
Ivermectin + Pyrantel As Pamoate Salt 10

Collapse of leg Reaction Insights

498 reports name Collapse of leg; 100 recorded a death outcome (20.1% of reported events, not a population-level mortality rate). VeDDRA code: 1389.

By species: Dog (463 reports), Cat (28 reports), Horse (3 reports). By breed: Retriever - Labrador (55), Crossbred Canine/dog (30), Retriever - Golden (26).

Most co-reported drugs: Bedinvetmab (144 reports), Sarolaner (52 reports), Carprofen (49 reports), Gabapentin (41 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.