Reaction profile

The FDA adverse-event record for pustules

684 FDA adverse-event reports reference pustules (VeDDRA 938). See the species, breeds, and drugs most associated with it below.

684
reports citing this reaction
5.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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684
Total Reports
35
Deaths
5.1%
Death Rate

Species Most Affected

Dog 649
Cat 30
Human 3
Horse 2

Breeds Most Affected

Retriever - Labrador 81
Crossbred Canine/dog 55
Retriever - Golden 37
Shepherd Dog - German 30
Pit Bull 30
Shih Tzu 17
Terrier - Bull - American Pit 17
Pug 17
Boxer (German Boxer) 16
Domestic Shorthair 16

Associated Drugs

Milbemycin Oxime + Spinosad 84
Afoxolaner 63
Fluralaner Chew Tablets 53
Oclacitinib Maleate 52
Spinosad 43
Prednisone 32
Carprofen 31
Selamectin 25
Trilostane 25
Enrofloxacin 22
Anti-Il31 Mab Mcs Lot #1283563 22
Ivermectin + Pyrantel As Pamoate Salt 21
Fluralaner 13.64% 12-Week Chew 21
Imidacloprid + Moxidectin 19
Cefpodoxime Proxetil 18
Cefovecin 18
Pyrantel Pamoate;Sarolaner 18
Bedinvetmab 17
Moxidectin 16
Cefpodoxime 15

Pustules Reaction Insights

684 reports name Pustules; 35 recorded a death outcome (5.1% of reported events, not a population-level mortality rate). VeDDRA code: 938.

By species: Dog (649 reports), Cat (30 reports), Human (3 reports). By breed: Retriever - Labrador (81), Crossbred Canine/dog (55), Retriever - Golden (37).

Most co-reported drugs: Milbemycin Oxime + Spinosad (84 reports), Afoxolaner (63 reports), Fluralaner Chew Tablets (53 reports), Oclacitinib Maleate (52 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.