Reaction profile

The FDA adverse-event record for expired drug administered

668 FDA adverse-event reports reference expired drug administered (VeDDRA 99830). See the species, breeds, and drugs most associated with it below.

668
reports citing this reaction
4.5%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
668
Total Reports
30
Deaths
4.5%
Death Rate

Species Most Affected

Dog 477
Cat 133
Unknown 21
Cattle 15
Horse 8
Pig 4
Human 4
Goat 2
Sheep 1
Ferret 1

Breeds Most Affected

Domestic Shorthair 76
Dog (unknown) 58
Retriever - Labrador 41
Crossbred Canine/dog 32
Chihuahua 31
Terrier - Yorkshire 28
Unknown 28
Pit Bull 23
Shih Tzu 20
Cat (unknown) 18

Associated Drugs

Spinosad 69
Milbemycin Oxime + Spinosad 62
Nitenpyram 56
Afoxolaner 48
Imidacloprid + Moxidectin 40
Selamectin 33
Ivermectin + Pyrantel As Pamoate Salt 29
Fluralaner Spot-On Solution 25
Insulin Injectable Vial 17
Fluralaner 13.64% 12-Week Chew 16
Fluralaner Chew Tablets 14
Sarolaner 14
Milbemycin Oxime + Praziquantel 12
Ivermectin + Pyrantel 11
Moxidectin 11
Milbemycin Oxime 9
Phenylpropanolamine Hcl 9
Prednisone 8
Orbiflox/Momet/Posaco Eardrops 7
Fenbendazol Granules 7

Expired drug administered Reaction Insights

668 reports name Expired drug administered; 30 recorded a death outcome (4.5% of reported events, not a population-level mortality rate). VeDDRA code: 99830.

By species: Dog (477 reports), Cat (133 reports), Unknown (21 reports). By breed: Domestic Shorthair (76), Dog (unknown) (58), Retriever - Labrador (41).

Most co-reported drugs: Spinosad (69 reports), Milbemycin Oxime + Spinosad (62 reports), Nitenpyram (56 reports), Afoxolaner (48 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.