Reaction profile

The FDA adverse-event record for licking at injection site

241 FDA adverse-event reports reference licking at injection site (VeDDRA 2752). See the species, breeds, and drugs most associated with it below.

241
reports citing this reaction
5.4%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
241
Total Reports
13
Deaths
5.4%
Death Rate

Species Most Affected

Dog 223
Cat 17
Other Birds 1

Breeds Most Affected

Retriever - Labrador 37
Retriever - Golden 18
Dog (unknown) 17
Boxer (German Boxer) 14
Pit Bull 12
Bulldog - French 11
Domestic Shorthair 11
Terrier (unspecified) 9
Chihuahua 9
Shepherd Dog - German 8

Associated Drugs

Tigilanol Tiglate 175
Diphenhydramine 51
Prednisone 46
Famotidine 46
Butorphanol 40
Gabapentin 40
Maropitant Citrate 37
Dexmedetomidine 29
Atipamezole 27
Butorphanol Tartrate 20
Atipamezole Hydrochloride 19
Dexmedetomidine Hydrochloride 16
Hydromorphone 15
Propofol 14
Buprenorphine 14
Carprofen 13
Ketamine 10
Frunevetmab 9
Bedinvetmab 8
Medetomidine 7

Licking at injection site Reaction Insights

241 reports name Licking at injection site; 13 recorded a death outcome (5.4% of reported events, not a population-level mortality rate). VeDDRA code: 2752.

By species: Dog (223 reports), Cat (17 reports), Other Birds (1 reports). By breed: Retriever - Labrador (37), Retriever - Golden (18), Dog (unknown) (17).

Most co-reported drugs: Tigilanol Tiglate (175 reports), Diphenhydramine (51 reports), Prednisone (46 reports), Famotidine (46 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.