Reaction profile

The FDA adverse-event record for scale

300 FDA adverse-event reports reference scale (VeDDRA 1196). See the species, breeds, and drugs most associated with it below.

300
reports citing this reaction
4.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
300
Total Reports
12
Deaths
4.0%
Death Rate

Species Most Affected

Dog 227
Cat 61
Cattle 6
Horse 4
Human 2

Breeds Most Affected

Retriever - Labrador 29
Domestic Shorthair 28
Crossbred Canine/dog 20
Shih Tzu 13
Retriever - Golden 10
Domestic (unspecified) 9
Maltese 9
Chihuahua 8
Dachshund (unspecified) 7
Shepherd Dog - German 7

Associated Drugs

Milbemycin Oxime + Spinosad 27
Oclacitinib Maleate 23
Afoxolaner 23
Selamectin 21
Carprofen 16
Prednisone 16
Trilostane 16
Spinosad 14
Cyclosporine 12
Ivermectin + Pyrantel As Pamoate Salt 12
Gabapentin 12
Cefovecin 11
Cefovecin Sodium 10
Fluralaner Chew Tablets 10
Imidacloprid + Moxidectin 9
Maropitant Citrate 9
Anti-Il31 Mab Mcs Lot #1283563 9
Bedinvetmab 9
Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On 8
Rabacfosadine Succinate 8

Scale Reaction Insights

300 reports name Scale; 12 recorded a death outcome (4.0% of reported events, not a population-level mortality rate). VeDDRA code: 1196.

By species: Dog (227 reports), Cat (61 reports), Cattle (6 reports). By breed: Retriever - Labrador (29), Domestic Shorthair (28), Crossbred Canine/dog (20).

Most co-reported drugs: Milbemycin Oxime + Spinosad (27 reports), Oclacitinib Maleate (23 reports), Afoxolaner (23 reports), Selamectin (21 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.