Reaction profile

The FDA adverse-event record for injection site mass

342 FDA adverse-event reports reference injection site mass (VeDDRA 2113). See the species, breeds, and drugs most associated with it below.

342
reports citing this reaction
5.0%
death-coded share
Dog
most-affected species
Melarsomine Dihydrochloride
most-associated drug
Verify with FDA CVM →
342
Total Reports
17
Deaths
5.0%
Death Rate

Species Most Affected

Dog 253
Cat 79
Cattle 6
Horse 3
Ferret 1

Breeds Most Affected

Crossbred Canine/dog 35
Domestic (unspecified) 31
Domestic Shorthair 31
Retriever - Labrador 27
Retriever - Golden 17
Chihuahua 13
Rottweiler 8
Shepherd Dog - Australian 7
Boxer (German Boxer) 7
Beagle 7

Associated Drugs

Melarsomine Dihydrochloride 97
Moxidectin 35
Cefovecin Sodium 28
Melarsomine Dihydrochloride Injection 23
Lufenuron 19
Ivermectin + Pyrantel As Pamoate Salt 19
Cefovecin 18
Afoxolaner 18
Maropitant 10
Carprofen 9
Methylprednisolone Acetate 8
Meloxicam 8
Imrab 3 Tf - 1905.23 8
Polysulfated Glycosaminoglycan 8
Rabies Virus,Pv-11,Killed 8
Glycosaminoglycan Polysulfate 7
Enrofloxacin 6
Praziquantel 5
Prednisone 5
Maropitant Citrate 5

Injection site mass Reaction Insights

342 reports name Injection site mass; 17 recorded a death outcome (5.0% of reported events, not a population-level mortality rate). VeDDRA code: 2113.

By species: Dog (253 reports), Cat (79 reports), Cattle (6 reports). By breed: Crossbred Canine/dog (35), Domestic (unspecified) (31), Domestic Shorthair (31).

Most co-reported drugs: Melarsomine Dihydrochloride (97 reports), Moxidectin (35 reports), Cefovecin Sodium (28 reports), Melarsomine Dihydrochloride Injection (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.