Reaction profile

The FDA adverse-event record for epistaxis

699 FDA reports name epistaxis, a high-volume reaction in the CVM extract (VeDDRA 864). Plate stamps and neighbourhood peers follow.

#512 of 2,481
by report volume (all reactions)
699
reports citing this reaction
34.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Epistaxis has 699 reports now versus 695 in that prior snapshot: 4 more (0.6%).

Report change
+4
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Epistaxis changes

FDA AER · VeDDRA plate

Code 864 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 699 reports
  • DEATH-HOT 34.8%
  • UPPER-Q #512/2481
  • PHOTO-FINISH Pustules
  • SPECIES-DOG Dog · 569
  • DRUG-LEAD Carprofen · 98
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Pustules (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Epistaxis

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Injection site necros… · near703Epistaxis · this reaction699Pustules · near699Unable to jump · near699Expired drug administ… · near695Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Epistaxis

Epistaxis: high death-coded share in the FDA AER plate

Signature read: 243 death-coded reports is a heavy tail count for Epistaxis in the CVM extract. Report volume is upper-third scale: 699 named reports in the openFDA extract. Death-coded share is upper-third: 243 of 699 reports (34.8% of named reports). Nearest volume peer: Pustules (±0 reports). Lead species Dog (569). Lead co-reported drug Carprofen (98).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 569
Cat 69
Horse 28
Cattle 26
Human 2
Other 1
Sheep 1
Pig 1
Ferret 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 71
Crossbred Canine/dog 66
Shepherd Dog - German 38
Retriever - Golden 33
Domestic Shorthair 26
Dog (unknown) 17
Beagle 16
Domestic (unspecified) 15
Shepherd Dog - Australian 15
Rottweiler 12

Associated Drugs

Carprofen 98
Oclacitinib Maleate 59
Maropitant Citrate 39
Deracoxib 36
Bedinvetmab 32
Trilostane 31
Moxidectin 30
Milbemycin Oxime + Spinosad 28
Afoxolaner 25
Firocoxib 24
Enrofloxacin 24
Prednisone 23
Doxycycline 22
Melarsomine Dihydrochloride 21
Meloxicam 21
Cefovecin 20
Tramadol 18
Polysulfated Glycosaminoglycan 18
Grapiprant 18
Fluralaner Chew Tablets 17

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Epistaxis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (699 here).

Similar death-coded share

Nearest other reactions by death-coded share (34.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Epistaxis (#512 of 2,481 by report volume); death-coded 34.8%. PlainBreed reaction plate · death-coded report count stamp 243 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →