Reaction profile

The FDA adverse-event record for pica nos

1,970 FDA adverse-event reports reference pica nos (VeDDRA 134). See the species, breeds, and drugs most associated with it below.

1,970
reports citing this reaction
4.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,970
Total Reports
94
Deaths
4.8%
Death Rate

Species Most Affected

Dog 1,868
Cat 91
Cattle 4
Chicken 2
Horse 2
Turkey 1
Unknown 1
Rat 1

Breeds Most Affected

Retriever - Labrador 211
Crossbred Canine/dog 180
Retriever - Golden 99
Dog (unknown) 85
Beagle 63
Shepherd Dog - German 62
Chihuahua 57
Boxer (German Boxer) 56
Terrier - Yorkshire 53
Pit Bull 50

Associated Drugs

Milbemycin Oxime + Spinosad 423
Afoxolaner 222
Ivermectin + Pyrantel As Pamoate Salt 188
Milbemycin Oxime + Praziquantel 175
Fluralaner Chew Tablets 150
Spinosad 110
Trilostane 73
Pyrantel Pamoate;Sarolaner 64
Imidacloprid + Moxidectin 61
Lotilaner 57
Fluralaner 13.64% 12-Week Chew 53
Grapiprant 43
Carprofen 37
Oclacitinib Maleate 37
Sarolaner 37
Maropitant Citrate 35
Ivermectin 32
Milbemycin Oxime, Lufenuron 31
Molidustat 30
Prednisone 28

Pica NOS Reaction Insights

1,970 reports name Pica NOS; 94 recorded a death outcome (4.8% of reported events, not a population-level mortality rate). VeDDRA code: 134.

By species: Dog (1,868 reports), Cat (91 reports), Cattle (4 reports). By breed: Retriever - Labrador (211), Crossbred Canine/dog (180), Retriever - Golden (99).

Most co-reported drugs: Milbemycin Oxime + Spinosad (423 reports), Afoxolaner (222 reports), Ivermectin + Pyrantel As Pamoate Salt (188 reports), Milbemycin Oxime + Praziquantel (175 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.