Reaction profile

The FDA adverse-event record for pinnal oedema

375 FDA adverse-event reports reference pinnal oedema (VeDDRA 363). See the species, breeds, and drugs most associated with it below.

375
reports citing this reaction
1.9%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
375
Total Reports
7
Deaths
1.9%
Death Rate

Species Most Affected

Dog 353
Cat 15
Human 4
Cattle 2
Rabbit 1

Breeds Most Affected

Retriever - Labrador 72
Retriever - Golden 39
Crossbred Canine/dog 26
Boxer (German Boxer) 24
Dachshund (unspecified) 14
Dog (unknown) 11
Shepherd Dog - German 10
Chihuahua 8
Beagle 8
Pug 7

Associated Drugs

Afoxolaner 63
Moxidectin 44
Maropitant Citrate 24
Milbemycin Oxime + Spinosad 23
Oclacitinib Maleate 21
Ivermectin + Pyrantel As Pamoate Salt 13
Fluralaner Chew Tablets 12
Spinosad 11
Carprofen 11
Anti-Il31 Mab Mcs Lot #1283563 10
Prednisone 9
Meloxicam 8
Betamethasone + Florfenicol + Terbinafine 8
Milbemycin Oxime + Praziquantel 8
Selamectin 7
Enrofloxacin + Silver Sulfadiazine 7
Diphenhydramine Hcl 7
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 7
Pyrantel Pamoate;Sarolaner 7
Diphenhydramine 6

Pinnal oedema Reaction Insights

375 reports name Pinnal oedema; 7 recorded a death outcome (1.9% of reported events, not a population-level mortality rate). VeDDRA code: 363.

By species: Dog (353 reports), Cat (15 reports), Human (4 reports). By breed: Retriever - Labrador (72), Retriever - Golden (39), Crossbred Canine/dog (26).

Most co-reported drugs: Afoxolaner (63 reports), Moxidectin (44 reports), Maropitant Citrate (24 reports), Milbemycin Oxime + Spinosad (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.